Recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid \u00df-peptide (A\u00df), the accumulation of which is thought central to the pathogenesis of Alzheimer disease (AD).<\/p>\n
This ARC explores the role of vesicular sorting proteins and other genes involved\u00a0\u00a0 in protein trafficking in the etiology and pathophysiology of AD and other neurodegenerative disorders. The power of this ARC lies in its interdisciplinary expertise and ability to validate any finding using independent approaches of genetic epidemiology, cell biology, model systems and pathology.<\/p>\n
HIGHLIGHTS<\/h5>\n
Notably, cognitive decline has been observed disproportionately in persons affected with MS and to a lesser extent with celiac disease, suggesting that these three diseases share a common immune or inflammatory pathway. Future studies of the protective mechanism of these HLA<\/em> alleles may provide insight into the neurobiology of cognitive decline and dementia and novel therapeutic approaches for these disorders.<\/p>\n This event will be held virtually on April 14th, 2025, 12pm-4pm EST.<\/p>\n Join us for the\u00a0<\/span>5th Annual Boston University Framingham Heart Study Brain Aging Program (FHS-BAP) Symposium (virtual) on Monday, April 14, 2025, from 12:00\u20134:00 PM (EST)<\/b>. This year\u2019s theme is\u00a0<\/span>\u201cImpact of the Exposome on Risk of Alzheimer\u2019s Disease and Related Dementias\u201d<\/b>, featuring six internationally renowned speakers presenting their latest research. <\/div>\n<\/div>\n\n Farrer, Lindsay, Medicine, Neurology, Ophthalmology, Epidemiology, Biostatistics Co-Directors Drs. Lindsay Farrer, Rhoda Au and Alice Cronin-Golomb Synopsis This ARC seeks to initiate a precision medicine program in Alzheimer disease (AD), a clinical area for which there is great need and broad expertise and resources at BU. We hypothesize that the reason current drugs used to treat AD are ineffective and clinical trial […]<\/p>\n","protected":false},"author":14042,"featured_media":0,"parent":3331,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3327"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/users\/14042"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/comments?post=3327"}],"version-history":[{"count":13,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3327\/revisions"}],"predecessor-version":[{"id":5566,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3327\/revisions\/5566"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3331"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/media?parent=3327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}5th Annual FHS-BAP Symposium<\/h4>
\nImpact of the Exposome on Risk of Alzheimer\u2019s Disease and Related Dementias<\/b><\/p>\n
For any questions, please contact Maria Dudek at\u00a0medudek@bu.edu<\/a>. We look forward to your participation<\/span><\/p>\n![\"\"](\"\/evanscenteribr\/files\/2025\/03\/Screenshot-2025-03-18-at-4.16.20-PM-1024x795.png\")
<\/p>\nARC Members
(This ARC includes 20 faculty from various disciplines)<\/strong><\/h4>\n
\nAu, Rhoda, Anatomy & Neurobiology
\nCronin-Golomb, Alice, Psychological & Brain Sciences
\nAbraham, Carmela, Biochemistry, Medicine
\nAdams, William, Pediatrics
\nBeffert, Uwe, Biology
\nBlusztajn, Jan, Pathology
\nBudson, Andrew, Cognitive Neuroscience
\nCheng, Christine, Biology
\nCruz-Martin, Alberto, Biology
\nFarrell, John, Medicine
\nGangopadhyay, Ashis, Mathematics & Statistics
\nGoldstein, Lee, Psychiatry
\nHarris, David, Bichemistry
\nHasselmo, Michael, Psychological & Brain Sciences
\nHo, Angela, Biology
\nIkezu, Tsuneya, Pharmacology
\nJun, Gyungah, Medcine
\nKalesan, Bindu, Transitional EPI
\nKolachalama, Vijaya, Medicine
\nKowall, Neil, Alzheimer Center
\nLin, Honghuang, Computational Biomedicine
\nLunetta, Kathryn, Biostatistics
\nLyons, Michael, Psychological & Brain Sciences
\nMcKee, Ann, Neurology
\nMez, Jesse, Neurology
\nMorgan, Kathleen, Rehabilitation Sciences
\nMoss, Mark , Anatomy & Neurobiology
\nQiu, Wendy, Psychiatry, Pharmacology
\nRyu, Hoon, Alzheimer Center
\nSchon, Karin, Anatomy & Neurobiology
\nSherva, Richard, Medicine
\nStein, Thor, Pathology & Lab Medicine
\nStern, Robert, Neurology
\nUnlu, Selim, Engineering
\nWolozin, Benjamin, Pharmacology
\nXia, Weiming, Pharmacology & Experimental Therapeutics
\nZhang, Xiaoling, Medicine<\/p>\n","protected":false},"excerpt":{"rendered":"