{"id":164,"date":"2011-05-30T22:14:49","date_gmt":"2011-05-31T02:14:49","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/csdl\/?page_id=164"},"modified":"2015-08-29T10:30:46","modified_gmt":"2015-08-29T14:30:46","slug":"cell-metabolism","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/csdl\/research-summary-2\/cell-metabolism\/","title":{"rendered":"AMPK, SREBP, and Lipid Metabolism"},"content":{"rendered":"<h4>Dr. Yu Li&#8217;s oral presentations in ADA webcasts <a href=\"http:\/\/professional.diabetes.org\/Adv_SearchResult.aspx?kwd=AMPK%20and%20Yu%20LI&amp;sr=pup&amp;ResType=ALL&amp;typ=10&amp;adv=False\">(2010)<\/a> (<a href=\"http:\/\/professional.diabetes.org\/Adv_SearchResult.aspx?kwd=AMPK%20and%20Yu%20Li&amp;sr=pup&amp;ResType=ALL&amp;typ=10&amp;adv=False\">2011<\/a>)<\/h4>\n<p style=\"text-align: left;\"><strong>AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin Resistance<\/strong><\/p>\n<p style=\"text-align: left;\"><strong><a href=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-9-502.jpg\"><img loading=\"lazy\" class=\"aligncenter size-medium wp-image-367\" title=\"Slide 1\" src=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-9-502-400x300.jpg\" alt=\"Slide 1\" height=\"300\" width=\"400\" srcset=\"https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-9-502-400x300.jpg 400w, https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-9-502.jpg 500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><\/strong><\/p>\n<p style=\"text-align: left;\"><strong><br \/>\n<\/strong><\/p>\n<p style=\"text-align: left;\"><strong>The Synthetic Polyphenol, S17834, Attenuates Accelerated Aortic Atherosclerosis in Insulin Resistant LDLR-\/- mice<\/strong><\/p>\n<p style=\"text-align: left;\"><strong><a href=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-8-50.jpg\"><img loading=\"lazy\" class=\"aligncenter size-medium wp-image-371\" title=\"Slide 1\" src=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-8-50-400x300.jpg\" alt=\"Slide 1\" height=\"300\" width=\"400\" srcset=\"https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-8-50-400x300.jpg 400w, https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-8-50.jpg 500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>\n<\/strong><\/p>\n<p style=\"text-align: left;\"><strong><br \/>\n<\/strong><\/p>\n<p style=\"text-align: center;\"><strong> <\/strong><\/p>\n<p style=\"text-align: left;\"><strong>Confocal Microscopy Image of Increased Nuclear SREBP-1 (Green) in the Hepatocytes of Insulin Resistant Mice and Eliminated by S17834 Treatment<\/strong><\/p>\n<p style=\"text-align: left;\"><strong><a href=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-6-501.jpg\"><img loading=\"lazy\" class=\"aligncenter size-medium wp-image-405\" title=\"Slide 1\" src=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-6-501-400x300.jpg\" alt=\"Slide 1\" height=\"300\" width=\"400\" srcset=\"https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-6-501-400x300.jpg 400w, https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-6-501.jpg 500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>\n<\/strong><\/p>\n<p style=\"text-align: left;\"><strong> <\/strong><\/p>\n<p style=\"text-align: left;\"><strong>AMPK Directly Phosphorylates human SREBP-1c at Ser372 in vitro <\/strong><\/p>\n<p style=\"text-align: left;\"><strong>Phospho-SREBP-1c (Ser372) antibody is available in Cell Signaling Technology (#9874)<a href=\"http:\/\/www.cellsignal.com\/products\/9874.html\"> <\/a><a href=\"http:\/\/www.cellsignal.com\/products\/9874.html\">(<\/a><\/strong><a href=\"http:\/\/www.cellsignal.com\/products\/9874.html\">http:\/\/www.cellsignal.com\/products\/9874.html)<\/a><\/p>\n<p style=\"text-align: left;\"><strong><a href=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-6-50.jpg\"><\/a><a href=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-2-50.jpg\"><img loading=\"lazy\" class=\"aligncenter size-medium wp-image-403\" title=\"Slide 1\" src=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-2-50-400x300.jpg\" alt=\"Slide 1\" height=\"300\" width=\"400\" srcset=\"https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-2-50-400x300.jpg 400w, https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-2-50-1024x768.jpg 1024w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>\n<\/strong><\/p>\n<p style=\"text-align: center;\"><strong> <\/strong><\/p>\n<p style=\"text-align: left;\"><strong>AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin Resistance<\/strong><\/p>\n<p style=\"text-align: left;\"><strong><a href=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-1-50.jpg\"><img loading=\"lazy\" class=\"aligncenter size-medium wp-image-370\" title=\"Slide 1\" src=\"\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-1-50-400x300.jpg\" alt=\"Slide 1\" height=\"300\" width=\"400\" srcset=\"https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-1-50-400x300.jpg 400w, https:\/\/www.bumc.bu.edu\/csdl\/files\/2011\/05\/2011_Dec_25_Web-design-1-50.jpg 500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><br \/>\n<\/strong><\/p>\n<p style=\"text-align: center;\"><strong><br \/>\n<\/strong><\/p>\n<p><strong> <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Yu Li&#8217;s oral presentations in ADA webcasts (2010) (2011) AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin Resistance The Synthetic Polyphenol, S17834, Attenuates Accelerated Aortic Atherosclerosis in Insulin Resistant LDLR-\/- mice Confocal Microscopy Image of Increased Nuclear SREBP-1 (Green) in the Hepatocytes of Insulin Resistant Mice and [&hellip;]<\/p>\n","protected":false},"author":1275,"featured_media":0,"parent":133,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages\/164"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/users\/1275"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/comments?post=164"}],"version-history":[{"count":48,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages\/164\/revisions"}],"predecessor-version":[{"id":442,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages\/164\/revisions\/442"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages\/133"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/media?parent=164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}