{"id":138,"date":"2009-02-19T22:46:49","date_gmt":"2009-02-20T03:46:49","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/csdl\/?page_id=138"},"modified":"2015-08-06T22:32:30","modified_gmt":"2015-08-07T02:32:30","slug":"selected-publications","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/csdl\/selected-publications\/","title":{"rendered":"The Website of Mengwei Zang’s Laboratory (Selected Publications)"},"content":{"rendered":"

Selective Original Articles:<\/span><\/strong><\/p>\n

    \n
  1. <\/strong>Li XY, Kover K, Heruth D, Watkins DJ, Moore WV, Zang M, <\/strong>Clements M, and Yun Yan. New insight into metformin action: regulation of ChREBP and FoXO1 activities in endothelial cells. Molecular Endocrinology<\/em>,<\/em><\/strong> 2015; in press.<\/li>\n
  2. <\/strong><\/span>Zang M. <\/strong>Targeting AMPK-SREBP nutrient sensing pathway has the therapeutic implication on insulin resistance and metabolic syndrome. Chinese Journal of Diabase Mellitus<\/em>, 2015; 7: 200-2004.<\/span><\/li>\n
  3. <\/strong>Li Y, Wong K, Giles A, Lee JW, Jiang J, Adams AC, Kharitonenkov <\/sup>A, Yang Q, Gao B, Guarente L, Zang M.<\/strong> Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology <\/em>(Impact Factor, 12.50),<\/em><\/strong> 2014; 146: 539-549.<\/em> PMCID: PMC4228483.<\/li>\n
  4. <\/strong>Li Y, Xu S, Jiang B, Cohen RA, Zang M.<\/strong> Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS One<\/em>, <\/em><\/strong>2013; 8: doi:10.1371. PMCID: 3692453.<\/li>\n
  5. <\/strong>Li Y, Wong K, Walsh K, Gao B, Zang M<\/strong>. Retinoic acid receptor \u03b2 stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. Journal of Biological Chemistry<\/em>, 2013; 288: 10490-10540, PMCID: 3624431.<\/li>\n
  6. Li Y, Xu S, Mihaylova M, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M<\/strong>. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin resistant mice. Cell Metabolism (Impact Factor, 17.350), 2011, 13(4):376-88. PMID: 21459323.\u00a0 PDF<\/a><\/li>\n
  7. Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M<\/strong>. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB Journal, 2011, 25(5):1664-79. PMID: 21321189. PDF<\/a><\/li>\n
  8. Xu S, Jiang B, Hou X, Shi C, Bachschmid M, Zang M<\/strong>, Verbeuren TJ, Cohen RA. High fat diet increases and the polyphenol, S17834, decreases acetylation of the SIRT1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol. 2011 Jun 3, in press. PMID: 21654327.<\/li>\n
  9. Ponugoti B, Xiao Z, Wu S, Chiang C, Zang M,<\/strong> Veenstra TD, Kemper J Kim. SIRT1 deacetylates and inhibits SREBP-1c activity in hepatic lipid metabolic regulation. Journal of Biological Chemistry, 2010; 285: 33959\u201333970. PMCID: PMC2962496. PDF<\/a><\/li>\n
  10. Luo Z, Zang M<\/strong>, Wen G. AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncology, 2010, 6: 457-470. PMCID: PMC2854547.<\/li>\n
  11. Wang J, Ma H, Tong C, Zhang H, Lawlis GB, Li Y, Zang M,<\/strong> Ren J, Nijland MJ, Ford SP, Nathanielsz PW, Li J. Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. FASEB Journal, 2010, 24:2066-2076. PMCID: PMC2874473. PDF<\/a><\/li>\n
  12. Tao R, Gong J, Luo X, Zang M,<\/strong> Guo W, Wen R, Luo Z. AMPK exerts dual regulatory effects on the PI3K pathway. Journal of Molecular Signaling, 2010, 5:1-9. PMCID: PMC2848036. PDF<\/a><\/li>\n
  13. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, K. Walsh, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M<\/strong>. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-Activated protein kinase. Journal of Biological Chemistry, 2008, 283: 20015-26. PMCID: PMC2459285. PDF<\/a><\/li>\n
  14. Zang M<\/strong>, Gong J, Luo L, Zhou J, Xiang X, Huang W, Huang Q, Luo X, Olbrot M, Peng Y, Chen C, Luo Z. Characterization of S338 phosphorylation for Raf-1 activation. Journal of Biological Chemistry, 2008, 283: 31429-37. PMCID: PMC2581588.<\/li>\n
  15. Zang M<\/strong>, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA. Polyphenols stimulate AMP-activated protein Kinase, lower lipids, and inhibit accelerated atherogenesis in diabetic LDL receptor-deficient mice. Diabetes, 2006, 55: 2180-2191. PMID: 16873680.<\/li>\n
  16. Zuccollo A, Shi C, Mastroianni R, Maitland KA, Weisbrod RM, Zang M<\/strong>, Xu S, Cayatte A, Corda S, Lavielle G, Verbeuren TJ, Cohen RA. The thromboxane A2 receptor antagonist, S18886, prevents enhanced atherogenesis caused by diabetes mellitus. Circulation, 2005, 112: 3001-3008. PMID: 16260636.<\/li>\n
  17. Zang M<\/strong>, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. Journal of Biological Chemistry, 2004, 279:47898-47905. PMID: 15371448.<\/li>\n
  18. Zang M<\/strong>, Dong M, Pinon DI, Ding X, Hadac EM, Miller LJ. Spatial approximation between a photolabile residue in position 13 of secretin and the amino-terminal tail of the secretin receptor. Molecular Pharmacology, 2003, 63: 993-1001. PMID: 12695527.<\/li>\n
  19. Dong M, Li Z, Zang M<\/strong>, Pinon DL, Lybrand TP, Miller LJ. Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Journal of Biological Chemistry, 2003, 278:48300-48312. PMID:14500709.<\/li>\n
  20. Xiang X, Zang M<\/strong>, Waelde CA, Wen R, Luo Z. Phosphorylation of S338SYY341 regulates specific interaction between Raf-1 and MEK1. Journal of Biological Chemistry, 2002, 277: 44996-45003. PMID: 12244094.<\/li>\n
  21. Zang M<\/strong>, Hayne C, Luo Z. Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. Journal of Biological Chemistry, 2002, 277: 4395-4405. PMID: 11733498.<\/li>\n
  22. Huang YZ, Zang M<\/strong>, Xiong WC, Luo Z, Mei L. Erbin suppresses the MAP kinase pathway: Down-regulation of AChR epsilon-subunit gene transcription. Journal of Biological Chemistry, 2002, 278, 1108-1114. PMID: 12379659.<\/li>\n
  23. Dong M, Zang M<\/strong>, Pinon DI, Li Z, Lybrand TP, Miller LJ. Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus. Molecular Endocrinology, 2002, 16: 2490-2501. PMID: 12403838.<\/li>\n
  24. Zang M<\/strong>, Waelde CA, Xiang X, Rana A, Wen R, Luo Z. Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. Journal of Biological Chemistry, 2001, 276: 25157-25165. PMID: 11274179.<\/li>\n
  25. Dong M, Asmann YW, Zang M<\/strong>, Pinon DI, Miller LJ. Identification of two pairs of spatially approximated residues within the carboxyl-terminus of secretin and its receptor. Journal of Biological Chemistry, 2000; 275: 26032-26039. PMID: 10859300.<\/li>\n
  26. Zang M<\/strong>, Meng A, Shen Q, Wang Q, Guo F, Liu JS. NO-cGMP signaling pathway is up-regulated in opiate tolerance and withdrawal. Acta Pharmaceutica Sinica, 2000; 35: 566-570.<\/li>\n
  27. Zang M<\/strong>, Shen Q, Sun Y, Wang Q, Liu JS. Mechanisms of opioid receptor-induced elevation in intracellular calcium measured by confocal laser scanning microscopy. Acta Academiae Medicinae Sinicae, 2000; 22: 254-258.<\/li>\n
  28. Zang M<\/strong>, Shen Q, Liu JS. Influence of nitric oxide synthase inhibitors on the signaling pathway of opiate tolerance and dependence in NG108-15 cells stably expressing iNOS gene. National Medical Journal of China, 1999; 79: 764-768.<\/li>\n
  29. Zang M<\/strong>, Meng A, Sun Y, Liu JS. Modulation of morphine tolerance by N-methyl-D-aspartate receptor antagonist MK801\uff1aassessment of opioid receptor and intracellular signaling changes. Chinese Journal of Anesthesiology, 1999; 19: 406-409.<\/li>\n
  30. Zang M<\/strong>, Meng A, Shen Q, Sun Y, Wang Q, Liu JS. Blockade of opioid tolerance and dependence by methylene blue. Acta Pharmaceutica Sinica, 1999; 34: 576-581.<\/li>\n
  31. Zang M<\/strong>, Shen Q, Wang Q, Guo F, Liu JS. Opiate receptor-mediated activation of adenylate cyclase-cAMP signaling is regulated by inducible nitric oxide synthase in neuronal cells. Acta Pharmaceutica Sinica, 1999; 34: 484-490.<\/li>\n
  32. Zang M<\/strong>, Wang Q, Shen Q, Liu JS, Peng XX. Stable expression of recombinant inducible nitric oxide synthase in NG108-15 cells and its biological characterization. Acta Biologiae Experimentalis Sinica, 1999; 33: 335-347.<\/li>\n
  33. Zang M<\/strong>, Shen Q, Wang Q, Liu JS. Retrovirus-mediated expression of inducible nitric oxide synthase and its function in neuronal cells. Acta Biochimica et Biophysica Sinica, 1999; 31: 233-238.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Selective Original Articles: Li XY, Kover K, Heruth D, Watkins DJ, Moore WV, Zang M, Clements M, and Yun Yan. New insight into metformin action: regulation of ChREBP and FoXO1 activities in endothelial cells. Molecular Endocrinology, 2015; in press. Zang M. Targeting AMPK-SREBP nutrient sensing pathway has the therapeutic implication on insulin resistance and metabolic […]<\/p>\n","protected":false},"author":1275,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages\/138"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/users\/1275"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/comments?post=138"}],"version-history":[{"count":28,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages\/138\/revisions"}],"predecessor-version":[{"id":434,"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/pages\/138\/revisions\/434"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/csdl\/wp-json\/wp\/v2\/media?parent=138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}