{"id":2518,"date":"2019-05-22T11:23:41","date_gmt":"2019-05-22T15:23:41","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/compbiomed\/?p=2518"},"modified":"2020-01-27T14:07:17","modified_gmt":"2020-01-27T19:07:17","slug":"tobacco-related-alterations-in-airway-gene-expression-are-rapidly-reversed-within-weeks-following-smoking-cessation","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/compbiomed\/2019\/05\/22\/tobacco-related-alterations-in-airway-gene-expression-are-rapidly-reversed-within-weeks-following-smoking-cessation\/","title":{"rendered":"New Publication: Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation"},"content":{"rendered":"<p>Kahkeshan Hijazi, Bozena Malyszko, Katrina Steiling, Xiaohui Xiao, Gang Liu, Yuriy O. Alekseyev, Yves-Martine Dumas, Louise Hertsgaard, Joni Jensen, Dorothy Hatsukami, Daniel R. Brooks, George O\u2019Connor, Jennifer Beane, Marc E. Lenburg &amp; Avrum Spira<\/p>\n<p>Monday, May 6, 2019<br \/>\nSource: <a href=\"https:\/\/www.nature.com\/\">Nature<\/a><\/p>\n<p><span>The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whole genome gene-expression profiling of individuals initiating a smoking-cessation attempt, we sought to characterize the kinetics of gene-expression alterations in response to short-term smoking-cessation in the nasal epithelium. RNA was extracted from the nasal epithelial of active smokers at baseline and at 4, 8, 16, and 24-weeks after smoking-cessation and put onto Gene ST arrays. Gene-expression levels of 119 genes were associated with smoking-cessation (FDR\u2009&lt;\u20090.05, FC \u22651.7) with a majority of the changes occurring by 8-weeks and a subset changing by 4-weeks. Genes down-regulated by 4- and 8-weeks post-smoking-cessation were involved in xenobiotic metabolism and anti-apoptotic functions respectively. These genes were enriched among genes previously found to be induced in smokers and following short-term\u00a0<\/span><i>in vitro<\/i><span>\u00a0exposure of airway epithelial cells to cigarette smoke (FDR\u2009&lt;\u20090.05). Our findings suggest that the nasal epithelium can serve as a minimally-invasive tool to measure the reversible impact of smoking and broadly, may serve to assess the physiological impact of changes in smoking behavior.<\/span><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-019-43295-3\">Read full publication<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kahkeshan Hijazi, Bozena Malyszko, Katrina Steiling, Xiaohui Xiao, Gang Liu, Yuriy O. Alekseyev, Yves-Martine Dumas, Louise Hertsgaard, Joni Jensen, Dorothy Hatsukami, Daniel R. Brooks, George O\u2019Connor, Jennifer Beane, Marc E. Lenburg &amp; Avrum Spira Monday, May 6, 2019 Source: Nature The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway [&hellip;]<\/p>\n","protected":false},"author":16142,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/posts\/2518"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/users\/16142"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/comments?post=2518"}],"version-history":[{"count":2,"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/posts\/2518\/revisions"}],"predecessor-version":[{"id":2556,"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/posts\/2518\/revisions\/2556"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/media?parent=2518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/categories?post=2518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/compbiomed\/wp-json\/wp\/v2\/tags?post=2518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}