{"id":18,"date":"2008-08-18T15:41:07","date_gmt":"2008-08-18T19:41:07","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/cto\/gastrointestinal\/"},"modified":"2024-09-24T15:20:37","modified_gmt":"2024-09-24T19:20:37","slug":"gastrointestinal","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/gastrointestinal\/","title":{"rendered":"Gastrointestinal"},"content":{"rendered":"<h3 style=\"text-align: center;\">Neuroendocrine:<\/h3>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03375320?term=NCT03375320&amp;rank=1\"><strong><strong>CIRB #H-42963\/ CTSU #A022001:<\/strong><\/strong><\/a> Phase II Randomized, Prospective Trial of Lutetium Lu 177 Dotatate PRRT Versus Capecitabine and Temozolomide in Well-Differentiated Pancreatic Neuroendocrine Tumors<\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05477576?term=NCT05477576&amp;rank=1\"><strong>Advarra IRB #H-43892\/ RayzeBio RYZ101-301:<\/strong><\/a> Phase 1b\/3 Global, Randomized, Controlled, Open-label Trial Comparing Treatment With RYZ101 to Standard of Care Therapy in Subjects With Inoperable, Advanced, SSTR+, Well-differentiated GEP-NETs That Have Progressed Following Prior 177Lu-SSA Therapy<\/p>\n<h3 style=\"text-align: center;\">Colorectal:<\/h3>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05610163?term=022104&amp;draw=2&amp;rank=1\"><strong>CIRB #H-43515\/ CTSU #A022104 (JANUS):<\/strong><\/a> The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing The Efficacy of Triplet Versus Doublet Chemotherapy to Achieve Clinical Complete Response in Patients With Locally Advanced Rectal Cancer<\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05174169?term=NCT05174169&amp;rank=1\"><strong>CIRB #H-44177\/ NRG GI008 (CIRCULATE-NORTH AMERICA):<\/strong><\/a> Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease<\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06562543?term=NCT06562543&amp;rank=1\"><strong>Advarra IRB #H-45290\/ Takeda #TAK-113-4002:<\/strong><\/a> A Single Arm Phase 4 Trial to Evaluate the Safety and Efficacy of Oral Fruquintinib in the Treatment of Refractory Metastatic Colorectal Cancer in Patients from Minority Populations Underrepresented in Prior Fruquintinib Studies <b>(pending IRB)<\/b><\/p>\n<h3 style=\"text-align: center;\">Pancreatic:<\/h3>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05968326?term=NCT05968326&amp;rank=1\"><strong>WCG IRB #H-43572\/ Genentech GO44479:<\/strong><\/a> A Phase II, Open-Label, Multicenter, Randomized Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Patients With Resected Pancreatic Ductal Adenocarcinoma<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04340141?term=NCT04340141&amp;draw=2&amp;rank=1\"><strong>CIRB #H-40808\/ CTSU #A021806:<\/strong><\/a> A Phase III Trial of Perioperative versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04340141?term=NCT04340141&amp;draw=2&amp;rank=1\"><strong>IRB #H-41225\/ Partners #Decision Aids:<\/strong><\/a> Development and Implementation of Electronic Decision Aids for Genetic Testing in Inherited Cancer Syndromes<\/p>\n<h3 style=\"text-align: center;\">Stomach\/Esophageal:<\/h3>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05677490?term=NCT05677490&amp;draw=2&amp;rank=1\"><strong>CIRB H-43647\/ CTSU #A022102:<\/strong><\/a> Randomized Phase III Trial of mFOLFIRINOX vs. FOLFOX With Nivolumab for First-Line Treatment of Metastatic HER2- Gastroesophageal Adenocarcinoma<\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05734105?term=NCT05734105&amp;rank=1\"><strong>WCG IRB #H-44285\/ Deciphera DCC-2618-03-003 (INSIGHT):<\/strong><\/a> An International, Phase 3, Randomized, Multicenter, Open-label Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With KIT Exon 11 and Co-occurring KIT Exons 17 and\/or 18 Mutations Who Were Previously Treated With Imatinib<\/p>\n<h3 style=\"text-align: center;\">Liver\/Hepatobiliary:<\/h3>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06040099?term=NCT06040099&amp;rank=1\"><strong>Central IRB #H-44599\/ AstraZeneca #EMERALD-Y90:<\/strong><\/a> Phase II Single-Arm Study of Durvalumab and Bevacizumab Following Transarterial Radioembolization Using Yttrium-90 Glass Microspheres (TheraSphere&#x2122;) in Unresectable Hepatocellular Carcinoma Amenable to Locoregional Therapy<\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06050252?term=NCT06050252&amp;rank=1\"><strong>CIRB #H-45085\/ ETCTN #10608:<\/strong><\/a> A Phase II Trial of Durvalumab with Gemcitabine and Cisplatin as Neoadjuvant Therapy for High-Risk Resectable Intrahepatic Cholangiocarcinoma<\/p>\n<h3 style=\"text-align: center;\">Anal:<\/h3>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04166318?term=NCT04166318&amp;draw=2&amp;rank=1\"><strong>CIRB #H-39855\/ CTSU #EA2182 (DECREASE):<\/strong><\/a> A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE)<\/p>\n<h3 style=\"text-align: center;\">Metastatic\/Advanced 2nd+ Line Solid Tumors:<\/h3>\n<p><em>KRAS\/NRAS\/HRAS\/BRAF positive<\/em><br \/>\n<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05111561?term=NCT05111561&amp;draw=2&amp;rank=1\"><strong><strong>CIRB #H-42956\/ ETCTN #10449:<\/strong><\/strong><\/a> A Phase 1 Study of ZEN003694 in Combination with Binimetinib in Solid Tumors with RAS Pathway Alterations and Triple Negative Breast Cancer <b>(temporary closure)<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neuroendocrine: CIRB #H-42963\/ CTSU #A022001: Phase II Randomized, Prospective Trial of Lutetium Lu 177 Dotatate PRRT Versus Capecitabine and Temozolomide in Well-Differentiated Pancreatic Neuroendocrine Tumors Advarra IRB #H-43892\/ RayzeBio RYZ101-301: Phase 1b\/3 Global, Randomized, Controlled, Open-label Trial Comparing Treatment With RYZ101 to Standard of Care Therapy in Subjects With Inoperable, Advanced, SSTR+, Well-differentiated GEP-NETs That [&hellip;]<\/p>\n","protected":false},"author":1006,"featured_media":0,"parent":0,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages\/18"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/users\/1006"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":50,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":5482,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages\/18\/revisions\/5482"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}