{"id":13,"date":"2008-05-30T16:28:29","date_gmt":"2008-05-30T20:28:29","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/cto\/amyloidosis\/"},"modified":"2024-09-23T11:49:20","modified_gmt":"2024-09-23T15:49:20","slug":"amyloidosis","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/amyloidosis\/","title":{"rendered":"Amyloidosis"},"content":{"rendered":"<h4>First Line:<\/h4>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04973137?term=NCT04973137&amp;draw=2&amp;rank=1\"><strong>Central IRB #H-41609\/ Prothena #NEOD001-301 (AFFIRM AL)<\/strong>:<\/a> A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05250973?term=NCT05250973&amp;draw=2&amp;rank=1\"><strong>Central IRB #H-42313\/ Janssen #AMY2009 (AQUARIUS)<\/strong>:<\/a> A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain (AL) Amyloidosis<\/p>\n<h4>Second+ Line:<\/h4>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04270175?term=NCT04270175&amp;draw=2&amp;rank=1\"><strong><strong>IRB #H-39705\/ Cornell Janssen DPd:<\/strong><\/strong><\/a> Daratumumab, Pomalidomide and Dexamethasone (DPd) in Relapsed\/ Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04847453?term=NCT04847453&amp;draw=2&amp;rank=1\"><strong><strong>CIRB #H-42375\/ NCI ETCTN #10440:<\/strong><\/strong><\/a> A Phase 1\/1a Study of Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for Relapsed\/Refractory Light Chain Amyloidosis<\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06158854?term=NCT06158854&amp;rank=1\"><strong>Advarra IRB #H-43903\/ AbbVie M24-209<\/strong>:<\/a> An Open-Label Phase 1b Study Evaluating the Safety and Efficacy of ABBV-383 in AL Amyloidosis<\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05451771?term=NCT05451771&amp;rank=1\"><strong>BMC IRB #H-43903\/ Columbia #AAAT8639<\/strong>:<\/a> An Open-label Phase I\/II Trial of Venetoclax-Dexamethasone in Relapsed and\/or Refractory t(11;14) Systemic Light-Chain Amyloidosis <b>(pending)<\/b><\/p>\n<p><a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06097832?term=NCT06097832&amp;rank=1\"><strong>Central IRB #pend\/ Naxcella #NXC-201-AL-001 (NEXICART-2)<\/strong>:<\/a> Phase 1b Dose Expansion Study of NXC-201 for the Treatment of Patients with Relapsed or Refractory AL Amyloidosis <b>(pending IRB)<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"<p>First Line: Central IRB #H-41609\/ Prothena #NEOD001-301 (AFFIRM AL): A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis Central IRB #H-42313\/ Janssen #AMY2009 (AQUARIUS): A Phase 2, Multicohort Study of Daratumumab-Based [&hellip;]<\/p>\n","protected":false},"author":1006,"featured_media":0,"parent":0,"menu_order":22,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages\/13"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/users\/1006"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/comments?post=13"}],"version-history":[{"count":49,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages\/13\/revisions"}],"predecessor-version":[{"id":5440,"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/pages\/13\/revisions\/5440"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/clinicaltrials\/wp-json\/wp\/v2\/media?parent=13"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}