{"id":5185,"date":"2012-08-07T09:00:01","date_gmt":"2012-08-07T13:00:01","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/care\/?page_id=5185"},"modified":"2025-10-02T12:17:49","modified_gmt":"2025-10-02T16:17:49","slug":"russia-arch-cohort","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/care\/research-studies\/russia-arch-cohort\/","title":{"rendered":"Russia ARCH Cohort"},"content":{"rendered":"

\u00a0<\/strong>\u00a0<\/strong><\/h3>\n

Principal Investigator <\/strong><\/h3>\n

Jeffrey Samet, MD, MA, MPH<\/a><\/p>\n

Key Personnel <\/strong><\/h3>\n

Matthew Freiberg, MD, MSc<\/a>, Co-Investigator<\/p>\n

Evgeny Krupitsky, MD, PhD, DMSci<\/a>, Co-Investigator & PI of Russian Subcontract<\/p>\n

Dmitry Lioznov, MD, PhD<\/a>, Co-Investigator<\/p>\n

Elena Blokhina, MD, PhD<\/a>, Co-Investigator<\/p>\n

Edwin Zvartau, MD, PhD, DMSci<\/a>, Co-Investigator & Russian Project Director<\/p>\n

Project Manager<\/strong><\/h3>\n

Natalia Gnatienko, MPH
\n617-414-3843
\nNatalia.Gnatienko@bmc.org<\/a><\/p>\n

Data from this study are available from our URBAN ARCH Repository<\/a>.<\/p>\n

Staff
\n<\/strong><\/h3>\n

Tatiana Yaroslavsteva – Russian Project Coordinator<\/p>\n

Grant Abstract<\/strong><\/h3>\n

Heavy alcohol consumption in an HIV-infected person may accelerate HIV disease progression and end organ disease with one leading explanatory pathway being via enhanced microbial translocation and inflammation\/altered coagulation. Heavy alcohol consumption and HIV infection are both causes of microbial translocation, the process by which bacterial products leak across the gastrointestinal membrane with resultant destructive immune activation. Among HIV-infected people, high levels of microbial translocation (as measured by soluble CD14) and inflammation\/altered coagulation (as measured by D- dimer) are each associated with an increased risk of death. Of importance, among HIV-infected persons, heavy drinking is also significantly associated with higher levels of D-dimer in cross-sectional studies. Of note, initiation of antiretroviral therapy (ART) is associated with a reduction in D-dimer levels. Yet the following is not known: is there a longitudinal relationship between alcohol consumption and these biomarkers independent of ART? Answering this question requires a setting with prevalent HIV infection, heavy alcohol use and limited current ART use. As Russia has a relatively young, expanding HIV epidemic, a growing HIV treatment infrastructure and enormous per capita alcohol consumption, St. Petersburg is a setting where this research is possible. Thus, as part of the Uganda, Russia, Boston Alcohol Network for Alcohol Research Collaboration on HIV\/AIDS (URBAN ARCH) Consortium, we seek to create the Russia ARCH cohort from participants of a recently completed NIAAA-funded randomized controlled trial (RCT) of HIV-infected Russian heavy drinkers and perform an assessment of the longitudinal association between alcohol consumption and biomarkers of microbial translocation (sCD14) and inflammation\/altered coagulation (D-dimer).This study will clarify the association between alcohol and key biomarkers overtime in HIV-infected heavy drinkers.<\/p>\n

URBAN ARCH Consortium website<\/a><\/p>\n

Publications <\/strong><\/h3>\n

URBAN ARCH Consortium publications<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0\u00a0 Principal Investigator Jeffrey Samet, MD, MA, MPH Key Personnel Matthew Freiberg, MD, MSc, Co-Investigator Evgeny Krupitsky, MD, PhD, DMSci, Co-Investigator & PI of Russian Subcontract Dmitry Lioznov, MD, PhD, Co-Investigator Elena Blokhina, MD, PhD, Co-Investigator Edwin Zvartau, MD, PhD, DMSci, Co-Investigator & Russian Project Director Project Manager Natalia Gnatienko, MPH 617-414-3843 Natalia.Gnatienko@bmc.org Data from […]<\/p>\n","protected":false},"author":5977,"featured_media":0,"parent":62,"menu_order":23,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/pages\/5185"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/users\/5977"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/comments?post=5185"}],"version-history":[{"count":17,"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/pages\/5185\/revisions"}],"predecessor-version":[{"id":15011,"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/pages\/5185\/revisions\/15011"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/pages\/62"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/care\/wp-json\/wp\/v2\/media?parent=5185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}