{"id":77,"date":"2006-12-07T15:50:32","date_gmt":"2006-12-07T19:50:32","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/clinical-projects\/interim-update-project-9-october-2005\/"},"modified":"2012-11-01T12:26:17","modified_gmt":"2012-11-01T16:26:17","slug":"interim-update-project-9-october-2005","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/interim-update-project-9-october-2005\/","title":{"rendered":"Interim Update Project 9 October 2005"},"content":{"rendered":"<p>Plans: The next year will focus upon the study of the clinical correlates of oxidative stress markers, exploring their relationship to echocardiographic left ventricular measurements, where appropriate.<\/p>\n<p>Investigators completed analyses of the clinical correlates of myeloperoxidase and its relation to echocardiographic LV phenotypes. Following are their conclusions.<\/p>\n<ul>\n<li>MPO was related inversely to age and female sex and positively to body mass index.<\/li>\n<li>Overall, clinical correlates could explain less than 5% of the inter-individual variability in MPO.<\/li>\n<li>MPO levels were modestly heritable (p=0.24).<\/li>\n<li>MPO was not related to LV mass, diastolic dimensions or wall thickness. However, MPO was inversely related to fractional shortening (borderline significance).<\/li>\n<\/ul>\n<p>Investigators described work performed earlier in the project, on clinical correlates of heat shock protein-70 and relationship of the biomarker to echocardiographic LV phenotypes, in a paper accepted in the <em>American Journal of Hypertension.<\/em> Dr. Ramachandran Vasan, who heads the project, became Associate Editor of <em>Circulation<\/em> in December 2004.<\/p>\n<p>Project research was presented at the recent American Heart Association meetings in Dallas, Texas. <a href=\"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/\/cpc-research-at-the-aha\/\">CPC Research at the AHA meetings 2005<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Plans: The next year will focus upon the study of the clinical correlates of oxidative stress markers, exploring their relationship to echocardiographic left ventricular measurements, where appropriate. Investigators completed analyses of the clinical correlates of myeloperoxidase and its relation to echocardiographic LV phenotypes. Following are their conclusions. MPO was related inversely to age and female [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":95,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/pages\/77"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/comments?post=77"}],"version-history":[{"count":5,"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/pages\/77\/revisions"}],"predecessor-version":[{"id":1930,"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/pages\/77\/revisions\/1930"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascularproteomics\/wp-json\/wp\/v2\/media?parent=77"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}