{"id":4020,"date":"2025-01-02T14:38:06","date_gmt":"2025-01-02T19:38:06","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/?page_id=4020"},"modified":"2025-09-08T14:10:37","modified_gmt":"2025-09-08T18:10:37","slug":"clinical-trial-research","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/research\/clinical-trial-research\/","title":{"rendered":"Clinical Trial Research"},"content":{"rendered":"<p>Explore our active clinical trials below, highlighting the innovative research opportunities aimed at advancing cardiovascular care and improving patient outcomes.<\/p>\n<p><!-- Clinical Trials Accordion (Updated) --><\/p>\n<style>\n  .cv-accordion { max-width: 900px; margin: 0 auto; font-family: system-ui, -apple-system, Segoe UI, Roboto, \"Helvetica Neue\", Arial, \"Noto Sans\", \"Liberation Sans\", sans-serif; }\n  .cv-accordion details { border: 1px solid #e5e7eb; border-radius: 12px; background: #fff; margin: 10px 0; box-shadow: 0 1px 2px rgba(16,24,40,.04); overflow: hidden; }\n  .cv-accordion summary { list-style: none; cursor: pointer; padding: 14px 18px; display: flex; align-items: center; justify-content: space-between; font-weight: 600; font-size: 1rem; }\n  .cv-accordion summary::-webkit-details-marker { display: none; }\n  .cv-accordion summary .chev { transition: transform .2s ease; }\n  details[open] summary .chev { transform: rotate(180deg); }\n  .cv-accordion .panel { padding: 6px 18px 16px; }\n  .cv-list { margin: 0; padding: 0; list-style: none; }\n  .cv-item { padding: 10px 0; border-top: 1px dashed #e5e7eb; display: grid; gap: 4px; }\n  .cv-item:first-child { border-top: 0; }\n  .cv-title { font-weight: 600; }\n  .cv-meta { color: #475467; font-size: .95rem; }\n  .cv-badges { display: inline-flex; gap: 6px; flex-wrap: wrap; }\n  .cv-badge { display: inline-block; font-size: .75rem; padding: 2px 8px; border-radius: 999px; background: #eef2ff; color: #3730a3; border: 1px solid #e0e7ff; vertical-align: middle; }\n  .cv-link { color: #0ea5e9; text-decoration: none; border-bottom: 1px dotted rgba(14,165,233,.5); }\n  .cv-link:hover { color: #0284c7; border-bottom-color: #0284c7; }\n<\/style>\n<div class=\"cv-accordion\" role=\"region\" aria-label=\"Cardiovascular Clinical Trials\">\n<p>  <!-- Heart Failure --><\/p>\n<details open>\n<summary>Heart Failure <span class=\"chev\">\u25be<\/span><\/summary>\n<div class=\"panel\">\n<ul class=\"cv-list\">\n<li class=\"cv-item\">\n<div class=\"cv-title\">Alleviant ALLAY-HF Study<\/div>\n<div class=\"cv-meta\">PI: Deepa Gopal<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT05685303\" target=\"_blank\" rel=\"noopener noreferrer\">NCT05685303<\/a>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">Alleviant ALLAY-HFrEF Study<\/div>\n<div class=\"cv-meta\">PI: Nir Ayalon<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06812533\" target=\"_blank\" rel=\"noopener noreferrer\">NCT06812533<\/a>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258) (FASTR-II)<\/div>\n<div class=\"cv-meta\">PI: Deepa Gopal<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06898515\" target=\"_blank\" rel=\"noopener noreferrer\">NCT06898515<\/a>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">PROACTIVE-HF IDE Trial Heart Failure NYHA Class III (PROACTIVE-HF)<\/div>\n<div class=\"cv-meta\">PI: Nir Ayalon<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT04089059\" target=\"_blank\" rel=\"noopener noreferrer\">NCT04089059<\/a>\n          <\/div>\n<\/li>\n<\/ul><\/div>\n<\/details>\n<p>  <!-- Hypertrophic Cardiomyopathy --><\/p>\n<details>\n<summary>Hypertrophic Cardiomyopathy <span class=\"chev\">\u25be<\/span><\/summary>\n<div class=\"panel\">\n<ul class=\"cv-list\">\n<li class=\"cv-item\">\n<div class=\"cv-title\">A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy (SONATA-HCM)<\/div>\n<div class=\"cv-meta\">PI: Wilson Colucci<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06481891\" target=\"_blank\" rel=\"noopener noreferrer\">NCT06481891<\/a>\n          <\/div>\n<\/li>\n<\/ul><\/div>\n<\/details>\n<p>  <!-- Amyloid --><\/p>\n<details>\n<summary>Amyloid <span class=\"chev\">\u25be<\/span><\/summary>\n<div class=\"panel\">\n<ul class=\"cv-list\">\n<li class=\"cv-item\">\n<div class=\"cv-title\">Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)<\/div>\n<div class=\"cv-meta\">PI: Omar Siddiqi<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT04601051\" target=\"_blank\" rel=\"noopener noreferrer\">NCT04601051<\/a>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant<\/div>\n<div class=\"cv-meta\">PI: Frederick Ruberg<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06563895\" target=\"_blank\" rel=\"noopener noreferrer\">NCT06563895<\/a>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">eMyosound<\/div>\n<div class=\"cv-meta\">PI: Deepa Gopal<\/div>\n<div class=\"cv-badges\">\n            <span class=\"cv-badge\">NCT: \u2014<\/span>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis<\/div>\n<div class=\"cv-meta\">PI: Frederick Ruberg<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06034405\" target=\"_blank\" rel=\"noopener noreferrer\">NCT06034405<\/a>\n          <\/div>\n<\/li>\n<\/ul><\/div>\n<\/details>\n<p>  <!-- Interventional Cardiology --><\/p>\n<details>\n<summary>Interventional Cardiology <span class=\"chev\">\u25be<\/span><\/summary>\n<div class=\"panel\">\n<ul class=\"cv-list\">\n<li class=\"cv-item\">\n<div class=\"cv-title\">Pulmonary Embolism &#8211; Thrombus Removal With Catheter-Directed Therapy (PE-TRACT)<\/div>\n<div class=\"cv-meta\">PI: Ashvin Pande<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT05591118\" target=\"_blank\" rel=\"noopener noreferrer\">NCT05591118<\/a>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">ELEVATE High-Risk PCI Pivotal Study (ELEVATE III)<\/div>\n<div class=\"cv-meta\">PI: Nir Ayalon<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT07001332\" target=\"_blank\" rel=\"noopener noreferrer\">NCT07001332<\/a>\n          <\/div>\n<\/li>\n<\/ul><\/div>\n<\/details>\n<p>  <!-- Myocarditis --><\/p>\n<details>\n<summary>Myocarditis <span class=\"chev\">\u25be<\/span><\/summary>\n<div class=\"panel\">\n<ul class=\"cv-list\">\n<li class=\"cv-item\">\n<div class=\"cv-title\">Abatacept in Immune Checkpoint Inhibitor Myocarditis (ATRIUM)<\/div>\n<div class=\"cv-meta\">PI: Omar Siddiqi<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT05335928\" target=\"_blank\" rel=\"noopener noreferrer\">NCT05335928<\/a>\n          <\/div>\n<\/li>\n<\/ul><\/div>\n<\/details>\n<p>  <!-- Electrophysiology --><\/p>\n<details>\n<summary>Electrophysiology <span class=\"chev\">\u25be<\/span><\/summary>\n<div class=\"panel\">\n<ul class=\"cv-list\">\n<li class=\"cv-item\">\n<div class=\"cv-title\">The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation (REACT-AF)<\/div>\n<div class=\"cv-meta\">PI: Robert Helm<\/div>\n<div class=\"cv-badges\">\n            <a class=\"cv-badge cv-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT05836987\" target=\"_blank\" rel=\"noopener noreferrer\">NCT05836987<\/a>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">Body Surface Mapping<\/div>\n<div class=\"cv-meta\">PI: Robert Helm<\/div>\n<div class=\"cv-badges\">\n            <span class=\"cv-badge\">NCT: \u2014<\/span>\n          <\/div>\n<\/li>\n<li class=\"cv-item\">\n<div class=\"cv-title\">Anodal Biphasic Pacing<\/div>\n<div class=\"cv-meta\">PI: Robert Helm<\/div>\n<div class=\"cv-badges\">\n            <span class=\"cv-badge\">NCT: \u2014<\/span>\n          <\/div>\n<\/li>\n<\/ul><\/div>\n<\/details>\n<p>  <!-- Cardiac Nuclear Medicine --><\/p>\n<details>\n<summary>Cardiac Nuclear Medicine <span class=\"chev\">\u25be<\/span><\/summary>\n<div class=\"panel\">\n<ul class=\"cv-list\">\n<li class=\"cv-item\">\n<div class=\"cv-title\">Safer3<\/div>\n<div class=\"cv-meta\">PI: Shivda Pandey<\/div>\n<div class=\"cv-badges\">\n            <span class=\"cv-badge\">NCT: \u2014<\/span>\n          <\/div>\n<\/li>\n<\/ul><\/div>\n<\/details>\n<\/div>\n<p><!-- \/Clinical Trials Accordion --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Explore our active clinical trials below, highlighting the innovative research opportunities aimed at advancing cardiovascular care and improving patient outcomes. Heart Failure \u25be Alleviant ALLAY-HF Study PI: Deepa Gopal NCT05685303 Alleviant ALLAY-HFrEF Study PI: Nir Ayalon NCT06812533 Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258) (FASTR-II) PI: Deepa Gopal [&hellip;]<\/p>\n","protected":false},"author":24339,"featured_media":0,"parent":408,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/pages\/4020"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/users\/24339"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/comments?post=4020"}],"version-history":[{"count":7,"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/pages\/4020\/revisions"}],"predecessor-version":[{"id":4510,"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/pages\/4020\/revisions\/4510"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/pages\/408"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/cardiovascular-medicine\/wp-json\/wp\/v2\/media?parent=4020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}