{"id":6362,"date":"2009-08-12T09:56:19","date_gmt":"2009-08-12T13:56:19","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/busm-news\/?p=316"},"modified":"2009-08-12T09:56:19","modified_gmt":"2009-08-12T13:56:19","slug":"mitochondrial-oxidative-stress-contributes-to-neurodegeneration-in-arteriogenic-ed-according-to-busm-researchers","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/camed\/2009\/08\/12\/mitochondrial-oxidative-stress-contributes-to-neurodegeneration-in-arteriogenic-ed-according-to-busm-researchers\/","title":{"rendered":"Mitochondrial Oxidative Stress Contributes to Neurodegeneration in Arteriogenic ED, According to BUSM researchers"},"content":{"rendered":"<p>According to researchers from BUSM&#8217;s departments of urology and pathology, neuropathy appears to follow vascular insult in arteriogenic Erectile Dysfunction (ED). In a recently published study in the British Journal of Urology the researchers found that neural injury in penile ischaemia involves a neurovascular phenomenon mediated by oxidative free radicals.<\/p>\n<p>&#8220;Mitochondrial structural damage and increased HIF-1 gene expression may be early signals of oxidative stress and neurodegeneration in ED,&#8221; said lead author Kazem M. Azadzoi, MD, MA, a research professor of urology and pathology and laboratory medicine at BUSM. Up-regulation of SOD, AR and NGF may be a coordinated defensive reaction to oxidative radicals in the ischaemic penis. The study introduces the new concept of oxidative neurodegeneration in the pathophysiology of arteriogenic ED.<\/p>\n<p>Therapeutic strategies to protect penile nerves from free radical incursion may enhance the efficacy of surgical and pharmacological interventions in arteriogenic ED.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to researchers from BUSM&#8217;s departments of urology and pathology, neuropathy appears to follow vascular insult in arteriogenic Erectile Dysfunction (ED). In a recently published study in the British Journal of Urology the researchers found that neural injury in penile ischaemia involves a neurovascular phenomenon mediated by oxidative free radicals. &#8220;Mitochondrial structural damage and increased [&hellip;]<\/p>\n","protected":false},"author":903,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/6362"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/users\/903"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/comments?post=6362"}],"version-history":[{"count":0,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/6362\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/media?parent=6362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/categories?post=6362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/tags?post=6362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}