{"id":5731,"date":"2015-01-20T09:00:48","date_gmt":"2015-01-20T14:00:48","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/busm\/?p=5731"},"modified":"2015-01-20T09:00:48","modified_gmt":"2015-01-20T14:00:48","slug":"a-new-tactic-for-fighting-cancer-2","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/camed\/2015\/01\/20\/a-new-tactic-for-fighting-cancer-2\/","title":{"rendered":"A New Tactic for Fighting Cancer"},"content":{"rendered":"<h3><a href=\"https:\/\/www.bumc.bu.edu\/camed\/2015\/01\/20\/a-new-tactic-for-fighting-cancer-2\/flynn-rachel\/\" rel=\"attachment wp-att-5732\"><img loading=\"lazy\" src=\"\/camed\/files\/2015\/01\/Flynn-Rachel-150x150.jpg\" alt=\"Flynn, Rachel\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-5732 alignleft\" \/><\/a>BU Today<\/h3>\n<h4><a href=\"http:\/\/www.bumc.bu.edu\/busm-pm\/faculty\/faculty-profiles\/flynn\/\">Rachel Flynn<\/a>, PhD, pharmacology and experimental therapeutics<\/h4>\n<p>By a quirk of biology, every time an adult cell divides, a bit of DNA gets lopped off the end of the double helix. This seems like a recipe for disaster\u2014imagine a crazed librarian ripping the last chapter off a book every time it got checked out. Soon, the book would be useless. So would truncated DNA, if not for structures called telomeres, long sequences of repetitive base pairs\u2014the same meaningless TTAGGG over and over\u2014that cap each end of our DNA. Every time a cell divides, it\u2019s a bit of telomere that gets chopped off, rather than vital genes.<\/p>\n<p>But biologists have long understood telomeres to be a double-edged sword. When they get too short, cells stop dividing. We see this as aging: hair turns gray, skin sags. But some cells are able to keep their telomeres long, effectively becoming immortal and dividing forever. Sometimes, the immortal cells become a cancer.<\/p>\n<p>Now, scientists led by\u00a0<a href=\"http:\/\/www.bumc.bu.edu\/busm-pm\/faculty\/faculty-profiles\/flynn\/\">Rachel L. Flynn<\/a>, a\u00a0<a href=\"https:\/\/www.bumc.bu.edu\/camed\/\">Boston University School of Medicine<\/a>\u00a0(MED) assistant professor of pharmacology and experimental therapeutics and medicine, have found a new way to kill certain cancers by targeting mechanisms of telomere elongation. The research, funded by the\u00a0<a href=\"http:\/\/www.nih.gov\/\">National Institutes of Health<\/a>, the\u00a0<a href=\"http:\/\/www.thefosterfoundation.org\/\">Foster Foundation<\/a>, and the\u00a0<a href=\"http:\/\/www.grunebaumfoundation.org\/\">Karin Grunebaum Cancer Research Foundation<\/a>, and published in the January 15, 2015, issue of\u00a0<a href=\"http:\/\/www.sciencemag.org\/content\/347\/6219\/273.short\"><i>Science<\/i><\/a>, may lead to new therapies for certain rare and deadly cancers that often appear in children.<\/p>\n<h3>Quote:<\/h3>\n<p>\u201cThe dream is that this research will eventually give kids with devastating cancers an option for individualized treatment, something that will hopefully improve outcomes,\u201d says Flynn.<\/p>\n<p>Read the <a href=\"http:\/\/www.bu.edu\/today\/2015\/a-new-tactic-for-fighting-cancer\/\">full article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BU Today Rachel Flynn, PhD, pharmacology and experimental therapeutics By a quirk of biology, every time an adult cell divides, a bit of DNA gets lopped off the end of the double helix. This seems like a recipe for disaster\u2014imagine a crazed librarian ripping the last chapter off a book every time it got checked [&hellip;]<\/p>\n","protected":false},"author":7398,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[126],"tags":[137],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/5731"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/users\/7398"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/comments?post=5731"}],"version-history":[{"count":0,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/5731\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/media?parent=5731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/categories?post=5731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/tags?post=5731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}