{"id":44518,"date":"2017-02-23T09:38:45","date_gmt":"2017-02-23T14:38:45","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/busm\/?p=44518"},"modified":"2017-02-23T11:03:29","modified_gmt":"2017-02-23T16:03:29","slug":"seshadri-team-publishes-nine-papers-using-framingham-heart-study-data","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/camed\/2017\/02\/23\/seshadri-team-publishes-nine-papers-using-framingham-heart-study-data\/","title":{"rendered":"Seshadri Team Publishes Nine Papers Using Framingham Study Data"},"content":{"rendered":"<figure id=\"attachment_35038\" aria-describedby=\"caption-attachment-35038\" style=\"width: 410px\" class=\"wp-caption alignright\"><img loading=\"lazy\" src=\"\/camed\/files\/2016\/07\/COM-Seshadri-h_butoday_16-9902-SESHADRI-052-e1487860279275.jpg\" alt=\"Sudha Seshadri, MD. Photo by Janice Checchio\" class=\"size-full wp-image-35038\" height=\"267\" width=\"400\" \/><figcaption id=\"caption-attachment-35038\" class=\"wp-caption-text\">Sudha Seshadri. Photo by Janice Checchio<\/figcaption><\/figure>\n<p>For more than 65 years researchers at the Framingham Heart Study (FHS) have worked to identify risk factors for cardiovascular disease; the role of genetic factors for stroke, Alzheimer\u2019s and Parkinson\u2019s diseases; and ultimately work toward the development of effective treatment and preventive strategies in clinical practice.<\/p>\n<p>Researchers have discovered that many of these conditions start as subtle brain changes 20-30 years before the first symptom, and that intervention at the preclinical stage may be the best option for preventing disease.<\/p>\n<p>BUSM Neurology Professor Sudha Seshadri, MD, leads research teams in the clinical neurology and neurogenetics cores at the FHS, where they explore the cumulated and age-specific impacts of a wide variety of genomic and environmental risk factors underlying stroke, dementia and brain aging across three generations of participants.<\/p>\n<p>January and February 2017 have been exceptionally fruitful months for Seshadri with nine published studies focusing on two themes: \u201cRisk factors for dementia and Alzheimers disease\u201d and \u201cPopulation neuroscience.&#8221; Specifically, four papers were published in <em>Stroke<\/em>; one each in <em>American Heart Association Journal,<\/em> <em>Nature Communications, Circulation<\/em> and <em>Current Alzheimer Research<\/em>. Additionally, one paper was published online in <em>Circulation<\/em> focusing on an updated version of the \u201cFramingham Stroke Risk Profile.\u201d<\/p>\n<p>\u201cResearchers are recognizing that clinical dementia occurs due to a <em>combination<\/em> of vascular brain injury and Alzheimer type changes, in most persons; how much of each and what else is contributing may vary between people,&#8221; said Seshadri.\u00a0 &#8220;Understanding how to predict and prevent dementia as one grows old depends on clearly understanding what midlife factors increase risk or protect from <em>both<\/em> stroke and neurodegeneration. Our team uses the uniquely rich, Framingham Heart Study data to try and uncover all genetic and vascular factors leading to dementia.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The studies focus on \u201cRisk factors for dementia and Alzheimers disease\u201d and \u201cPopulation neuroscience.&#8221; <\/p>\n","protected":false},"author":903,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[91,90],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/44518"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/users\/903"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/comments?post=44518"}],"version-history":[{"count":4,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/44518\/revisions"}],"predecessor-version":[{"id":44548,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/44518\/revisions\/44548"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/media?parent=44518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/categories?post=44518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/tags?post=44518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}