{"id":34404,"date":"2016-06-20T16:30:07","date_gmt":"2016-06-20T20:30:07","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/busm\/?p=34404"},"modified":"2016-06-20T16:30:07","modified_gmt":"2016-06-20T20:30:07","slug":"nikolajczyk-to-study-role-immune-cells-play-in-type-2-diabetes-and-periodontal-disease","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/camed\/2016\/06\/20\/nikolajczyk-to-study-role-immune-cells-play-in-type-2-diabetes-and-periodontal-disease\/","title":{"rendered":"Nikolajczyk to Study Role Immune Cells Play in Type 2 Diabetes and Periodontal Disease"},"content":{"rendered":"<p><img loading=\"lazy\" src=\"\/camed\/files\/2016\/06\/COM-Nikolajczyk-Barbara.jpg\" alt=\"COM Nikolajczyk Barbara\" class=\"alignright size-full wp-image-34408\" height=\"188\" width=\"188\" srcset=\"https:\/\/www.bumc.bu.edu\/camed\/files\/2016\/06\/COM-Nikolajczyk-Barbara.jpg 188w, https:\/\/www.bumc.bu.edu\/camed\/files\/2016\/06\/COM-Nikolajczyk-Barbara-150x150.jpg 150w, https:\/\/www.bumc.bu.edu\/camed\/files\/2016\/06\/COM-Nikolajczyk-Barbara-100x100.jpg 100w\" sizes=\"(max-width: 188px) 100vw, 188px\" \/>Barbara Nikolajczyk, PhD, associate professor of microbiology, has received a five-year, $2.95 million grant from the National Institute of Dental and Craniofacial Research (NIDCR).<\/p>\n<p>Nikolajczyk\u2019s research focuses on immuno-metabolism, or the role the immune system plays in obesity and obesity-associated complications like type 2 diabetes.Type 2 diabetes makes people more likely to have problems with oral health and has been shown to promote periodontal disease. In turn, periodontal disease appears to exacerbate type 2 diabetes. Immune cells are known to be the major source of inflammation that promotes both type 2 diabetes and periodontal complications of the disease.<\/p>\n<p>The grant will help fund a series of studies to determine the role various immune system cells and molecules play in the pathogenic relationship between type 2 diabetes and periodontal disease. It is hoped that this analysis may one day soon lead to treatments that improve type 2 diabetes while at the same time improving oral health.<\/p>\n<p>Nikolajczyk published the first definitive analyses showing B cells uniquely support periodontal disease in type 2 diabetes. This work includes a molecular understanding of mechanisms responsible for pro-inflammatory lymphocyte functions in these patients.<\/p>\n<p>The mission of the NIDCR is to improve oral, dental, and craniofacial health through research, research training and the dissemination of health information<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Barbara Nikolajczyk, PhD, associate professor of microbiology received a five year, $2.95 M grant from the National Institute of Dental and Craniofacial Research. <\/p>\n","protected":false},"author":903,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[91,143,90],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/34404"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/users\/903"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/comments?post=34404"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/34404\/revisions"}],"predecessor-version":[{"id":34409,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/posts\/34404\/revisions\/34409"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/media?parent=34404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/categories?post=34404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/tags?post=34404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}