{"id":112214,"date":"2023-03-31T09:27:48","date_gmt":"2023-03-31T13:27:48","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/busm\/?p=112214"},"modified":"2023-03-31T09:27:48","modified_gmt":"2023-03-31T13:27:48","slug":"centenarians-possess-unique-immunity-that-helps-them-achieve-exceptional-longevity","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/camed\/2023\/03\/31\/centenarians-possess-unique-immunity-that-helps-them-achieve-exceptional-longevity\/","title":{"rendered":"Centenarians Possess Unique Immunity that Helps them Achieve Exceptional Longevity"},"content":{"rendered":"

There are approximately 30 trillion cells in a human body and our health is predicated on them properly interacting with and supporting each other, with the immune system playing a particularly pivotal role. One of the defining characteristics of aging is a decline in the proper functioning of our immune system. Centenarians, a rare population of individuals who reach 100 years or more, experience delays in aging-related diseases and mortality which suggests their immune systems remain functional into extreme old age.<\/p>\n

Led by researchers from Boston University Chobanian & Avedisian School of Medicine and Tufts Medical Center, a new study finds centenarians harbor distinct immune cell type composition and activity and possess highly functional immune systems that have successfully adapted to a history of sickness allowing for exceptional longevity. These immune cells may help identify important mechanisms to recover from disease and promote longevity. \u201cOur data support the hypothesis that centenarians have protective factors that enable to recover from disease and reach extreme old ages,\u201d said lead author Tanya Karagiannis, PhD, senior bioinformatician, Center for Quantitative Methods and Data Science, Institute for Clinical Research and Health Policy Studies at Tufts Medical Center.<\/p>\n

\"Headshot\u201cWe assembled and analyzed what is, to our knowledge, the largest single-cell dataset of centenarian subjects that allowed us to define unique features of this population that support the identification of molecular and lifestyle factors contributing to their longevity,\u201d explained senior author Stefano Monti<\/a>, PhD, associate professor of medicine at the School of Medicine.<\/p>\n

To identify immune-specific patterns of aging and extreme human longevity, the researchers performed single cell sequencing on peripheral blood mononuclear cells (PBMCs)\u2014a broad category of immune cells circulating in the blood \u2013 taken from seven centenarians enrolled in\u00a0the\u00a0New England Centenarian Study<\/em>, one of\u00a0the largest\u00a0studies of long-lived individuals in North America led by \"thomasThomas Perls<\/a>, MD, at the School of Medicine. They then integrated this dataset with two publicly available single\u2010cell RNA sequencing (scRNA-seq) datasets of PBMCs to investigate compositional and transcriptional changes in circulating immune profiles across the human lifespan and extreme old age. Lastly, they applied advanced computational techniques to analyze the combined data, to evaluate how the cell type composition (the proportion of different cell types) and activity change as a function of age, and whether centenarians manifest profiles capturing or escaping the expected age progression.<\/p>\n

Their analysis confirms observations made in previous studies of aging and identifies novel cell type-specific compositional and transcriptional changes that are unique to centenarians and reflect normal immune response.<\/p>\n

According to the researchers, when people are exposed to infections and recover from them, their immune system learns to adapt, but this ability to respond declines as we age. \u201cThe immune profiles that we observed in the centenarians confirms a long history of exposure to infections and capacity to recover from them and provide support to the hypothesis that centenarians are enriched for protective factors that increase their ability to recover from infections,\u201d said senior author Paola Sebastiani, PhD, director, Center for Quantitative Methods and Data Science, Institute for Clinical Research and Health Policy Studies at Tufts Medical Center.<\/p>\n

\"HeadshotThe researchers believe these findings provide a foundation to investigate mechanisms of immune resilience likely contributing to extreme longevity as a target for healthy aging therapeutics. \u201cCentenarians, and their exceptional longevity, provide a \u2018blueprint\u2019 for how we might live more productive, healthful lives.\u00a0 We hope to continue to learn everything we can about resilience against disease and the extension of one\u2019s health span,\u201d said senior author George J. Murphy<\/a>, PhD, associate professor of medicine at the School of Medicine.<\/p>\n

These findings<\/a> appear online in the journal Lancet eBiomedicine.<\/p>\n","protected":false},"excerpt":{"rendered":"

Results will provide the basis for future studies to investigate the essentiality of these differences to escape aging-related disease.
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