{"id":143078,"date":"2026-03-24T17:31:58","date_gmt":"2026-03-24T21:31:58","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/camed\/?post_type=bu-article&p=143078"},"modified":"2026-03-24T17:31:59","modified_gmt":"2026-03-24T21:31:59","slug":"researchers-identify-genes-for-predicting-lung-cancer-recurrence","status":"publish","type":"bu-article","link":"https:\/\/www.bumc.bu.edu\/camed\/news-events\/articles\/2026\/researchers-identify-genes-for-predicting-lung-cancer-recurrence\/","title":{"rendered":"Researchers Identify Genes for Predicting Lung Cancer Recurrence"},"content":{"rendered":"\t
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Lung cancer desmoplasia, courtesy of the National Cancer Institute on Unsplash.<\/p>\n\t\t\t\n\n\t\t\t\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tResearchers Identify Genes for Predicting Lung Cancer Recurrence<\/strong>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/h1>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t

Knowing which cases may recur helps surgeons select the right surgical approach.\u00a0<\/em> <\/h4>\n\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t<\/div>\n\n\t\t\n\t<\/div>\n\n\t\n
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March 24, 2026<\/div>\n\t\t\n\t\t\t\t
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Lung cancer is the leading cause of death from cancer. It kills more people in the U.S. than breast, prostate and colon cancer combined. When lung adenocarcinoma, the most common primary lung cancer in the U.S., grows into nearby blood vessels (a process called vascular invasion), the tumor is more likely to recur even if surgically removed. Pathologists can identify areas of vascular invasion post-operatively, but surgeons could perform more extensive surgery to lower the risk of recurrence if they could predict which tumors were more likely to have vascular invasion.<\/p>\n\n\n\n

We think this is a potential game changer for patients with early-stage lung cancer. Our findings suggest a simple biopsy-based test could help doctors better identify patients at higher risk of recurrence and guide treatment decisions.<\/p>Marc Lenburg, PhD, professor of medicine, bioinformatics and pathology <\/cite><\/blockquote>\n\n\n\n

Researchers from Boston University Chobanian & Avedisian School of Medicine believe they have, for the first time, identified genes<\/a> whose activity changes in lung tumors with vascular invasion. Additionally, they also discovered that they could detect these changes in small pieces of the tumor collected during a presurgical biopsy procedure.  <\/p>\n\n\n\n

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Marc Lenburg, PhD<\/figcaption><\/figure><\/div>\n\n\n\n

\u201cWe think this is a potential game changer for patients with early-stage lung cancer,\u201d says corresponding author Marc Lenburg<\/a>, PhD, professor of medicine, bioinformatics and pathology at the school. \u201cOur findings suggest a simple biopsy-based test could help doctors better identify patients at higher risk of recurrence and guide treatment decisions.\u201d<\/p>\n\n\n\n

Using gene activity measurements, the researcher found more than 400 genes that differ between tumors with and without vascular invasion and confirmed these patterns in an independent cohort. They then developed and validated a machine-learning predictor that predicts whether vascular invasion is present. They found this test worked well at predicting tumor recurrence in other datasets and, crucially, gave accurate results about vascular invasion when measured in tiny biopsy samples taken before surgery.<\/p>\n\n\n\n

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Gene activity specific to vascular invasion is widespread in the tumor. The red spot in panel H is an area where tumor cells are actively invading a blood vessel. Panels 1\u20133 map the activity of three different invasion-related gene groups (purple = low, orange = high). The invaded vessel is outlined in white. All three gene groups have high activity spreading well beyond that outline. This broad pattern of activity helps identify tumors with vascular invasion.<\/figcaption><\/figure><\/div>\n\n\n\n

The researchers believe this predictor will play an important role in picking a treatment matched to how aggressive the tumor is. \u201cWhen lung cancer is detected early, there is a higher likelihood it can be cured. We want to get the treatment right: we don\u2019t want to undertreat an aggressive cancer and risk recurrence, but we also don\u2019t want to over-treat a less aggressive cancer. The ability to know this prior to surgery will allow the surgeon to choose the right surgical approach,\u201d adds Lenburg. <\/p>\n\n\n\n

According to the researchers, there is growing evidence that vascular invasion is associated with poor prognosis in other kinds of cancer, such as breast, liver and gastric cancer. The researchers need to determine if the same genes that are active in vascular-invasive lung adenocarcinoma are altered in other cancers.<\/p>\n\n\n\n

The study was a collaboration between researchers from Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Inova Schar Cancer Center and Lahey Hospital & Medical Center, part of Beth Israel Lahey Health. <\/p>\n\n\n\n

\u201cThis project began years ago due to the persistent clinical challenge: we need a better way to identify high\u2011risk tumors from just a biopsy. This multidisciplinary collaboration allowed us to turn that challenge into a new molecular approach that can screen early\u2011stage lung cancer patients for the biology linked to vascular invasion. It\u2019s a powerful example of how clinical insight and advanced analytics can come together to improve patient care,\u201d said coauthor Kimberly Rieger\u2011Christ, PhD, department of translational research, Lahey Hospital & Medical Center, Beth Israel Lahey Health.<\/p>\n\n\n\n

These findings appear online<\/a> in the journal Nature Communications.<\/p>\n","protected":false},"excerpt":{"rendered":"

Lung cancer is the leading cause of death from cancer. It kills more people in the U.S. than breast, prostate and colon cancer combined. When lung adenocarcinoma, the most common primary lung cancer in the U.S., grows into nearby blood vessels (a process called vascular invasion), the tumor is more likely to recur even if […]<\/p>\n","protected":false},"author":903,"featured_media":143081,"comment_status":"closed","ping_status":"closed","template":"","meta":{"bu_prepress_billboard":"","_bu_prepress_primary_term":"","_bu_prepress_primary_term_manual":"Research"},"tags":[94],"bu-publication":[367],"medicine-article-category":[],"medicine-topic":[],"news-article-category":[385],"news-topic":[],"bu_edition":[390],"media_type":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/bu-article\/143078"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/bu-article"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/types\/bu-article"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/users\/903"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/comments?post=143078"}],"version-history":[{"count":4,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/bu-article\/143078\/revisions"}],"predecessor-version":[{"id":143084,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/bu-article\/143078\/revisions\/143084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/media\/143081"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/media?parent=143078"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/tags?post=143078"},{"taxonomy":"bu-publication","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/bu-publication?post=143078"},{"taxonomy":"medicine-article-category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/medicine-article-category?post=143078"},{"taxonomy":"medicine-topic","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/medicine-topic?post=143078"},{"taxonomy":"news-article-category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/news-article-category?post=143078"},{"taxonomy":"news-topic","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/news-topic?post=143078"},{"taxonomy":"bu_edition","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/bu_edition?post=143078"},{"taxonomy":"media_type","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/camed\/wp-json\/wp\/v2\/media_type?post=143078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}