{"id":133487,"date":"2025-04-23T16:39:59","date_gmt":"2025-04-23T20:39:59","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/camed\/?post_type=bu-article&p=133487"},"modified":"2025-04-23T16:56:46","modified_gmt":"2025-04-23T20:56:46","slug":"researchers-identify-pathway-responsible-for-calciphylaxis-a-rare-and-serious-condition","status":"publish","type":"bu-article","link":"https:\/\/www.bumc.bu.edu\/camed\/news-events\/articles\/2025\/researchers-identify-pathway-responsible-for-calciphylaxis-a-rare-and-serious-condition\/","title":{"rendered":"Researchers Identify Pathway Responsible for Calciphylaxis, a Rare and Serious Condition"},"content":{"rendered":"\t
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Three small arterioles in a calciphylaxis skin biopsy of a 59-year-old male patient. The vessels show endothelial damage and thrombosis due to increased IL-6 (red) in the endothelial cells (pink) and interstitium.<\/p>\n\t\t\t\n\n\t\t\t\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tResearchers Identify Pathway Responsible for Calciphylaxis,<\/strong> a Rare and Serious Condition\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/h1>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t<\/div>\n\n\t\t\n\t<\/div>\n\n\t\n
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The global burden of chronic kidney disease (CKD) is rising, with more than 800 million people affected worldwide. Vascular diseases in patients with CKD are unique and grouped as uremic vascular diseases. One of them, calciphylaxis, typically affects patients with end-stage, advanced kidney disease. It is a condition characterized by severe, painful and non-healing skin ulcers with no known cure.<\/p>\n\n\n\n

For the first time, researchers from Boston University Chobanian & Avedisian School of Medicine in collaboration with the Massachusetts General Hospital, have discovered a novel biological pathway, called the IL6 pathway,central to the skin lesion initiation and progression. Blocking this pathway they believe, will likely prevent progression of the skin ulcers and resolve the pain seen in patients with calciphylaxis.<\/p>\n\n\n\n

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Vipul Chitalia, MD, PhD<\/figcaption><\/figure><\/div>\n\n\n\n

\u201cThis study reveals the presence of a pathological and harmful cycle between the fat under the skin, sweat glands and small blood vessels that keep feeding onto itself. If this cycle isn\u2019t stopped and remains unchecked, it will lead to the skin ulcers that won\u2019t heal. Using the specific pathway we identified, we could break this cycle and prevent the skin ulcers from getting worse,\u201d explained corresponding author Vipul Chitalia<\/a>, MD, PhD, professor of medicine. <\/p>\n\n\n\n

In the study<\/a>, human calciphylaxis skin and blood samples were examined for proteins and genes to analyze alterations in disease-causing mechanisms. An FDA-approved drug was then applied to see if the disease-causing pathway could be suppressed.<\/p>\n\n\n\n