Yuzuru Sasamoto, MD, PhD

Assistant Professor, Ophthalmology

Yuzuru Sasamoto
72 E. Concord Street


Yuzuru Sasamoto received his MD from Osaka University Medical School in Japan in 2006. After completion of his medical training in ophthalmology, he received a PhD degree from Osaka University Graduate School of Medicine in 2016. During his PhD program, he worked on corneal regeneration using techniques such as direct reprogramming and induced pluripotent stem (iPS) cell differentiation. He is currently an associate geneticist at the Brigham and Women’s Hospital. Yuzuru is currently working on the comprehensive characterization of the ABCB5 positive limbal stem cells using next-generation sequencing approaches.


  • Published on 9/3/2023

    Sasamoto Y, Yeung PC, Tran J, Frank MH, Frank NY. Protocol for isolating human BCAM-positive corneal progenitor cells by flow cytometry and cell sorting. STAR Protoc. 2023 Sep 03; 4(3):102503. PMID: 37669162.

    Read at: PubMed
  • Published on 2/2/2023

    Sasamoto Y, Wu S, Lee CAA, Jiang JY, Ksander BR, Frank MH, Frank NY. Epigenetic Regulation of Corneal Epithelial Differentiation by TET2. Int J Mol Sci. 2023 Feb 02; 24(3). PMID: 36769164.

    Read at: PubMed
  • Published on 8/9/2022

    Sasamoto Y, Lee CAA, Wilson BJ, Buerger F, Martin G, Mishra A, Kiritoshi S, Tran J, Gonzalez G, Hildebrandt F, Jo VY, Lian CG, Murphy GF, Ksander BR, Frank MH, Frank NY. Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation. Cell Rep. 2022 Aug 09; 40(6):111166. PMID: 35947947.

    Read at: PubMed
  • Published on 6/23/2022

    Yoshinaga Y, Soma T, Azuma S, Maruyama K, Hashikawa Y, Katayama T, Sasamoto Y, Takayanagi H, Hosen N, Shiina T, Ogasawara K, Hayashi R, Nishida K. Long-term survival in non-human primates of stem cell-derived, MHC-unmatched corneal epithelial cell sheets. Stem Cell Reports. 2022 07 12; 17(7):1714-1729. PMID: 35750044.

    Read at: PubMed
  • Published on 10/13/2021

    Sasamoto Y, Lee CAA, Yoshihara M, Martin G, Ksander BR, Frank MH, Frank NY. High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells. Ocul Surf. 2022 01; 23:197-200. PMID: 34653711.

    Read at: PubMed
  • Published on 6/5/2021

    Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience. 2021 Jun 25; 24(6):102688. PMID: 34195566.

    Read at: PubMed
  • Published on 10/24/2019

    Sasamoto Y, Sasamoto N, Tran J, Mishra A, Ksander BR, Frank MH, Frank NY. Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors. Ocul Surf. 2020 01; 18(1):114-120. PMID: 31655212.

    Read at: PubMed
  • Published on 9/12/2019

    Fujimoto S, Hayashi R, Hara S, Sasamoto Y, Harrington J, Tsujikawa M, Nishida K. KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-ß2 suppression. Regen Ther. 2019 Dec; 11:249-257. PMID: 31538102.

    Read at: PubMed
  • Published on 3/6/2018

    Sasamoto Y, Ksander BR, Frank MH, Frank NY. Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies. Expert Opin Biol Ther. 2018 05; 18(5):505-513. PMID: 29471701.

    Read at: PubMed
  • Published on 1/1/2018

    Iwama Y, Soma T, Maeda N, Sasamoto Y, Oie Y, Koh S, Nishida K. Factors Limiting the Visual Outcome After Descemet Stripping Automated Endothelial Keratoplasty: Comprehensive Analysis Including the Graft Position and Irregularity. Cornea. 2018 Jan; 37(1):20-27. PMID: 29040117.

    Read at: PubMed

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