James A. Hamilton, PhD
Professor, Pharmacology, Physiology & Biophysics
Biography
Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.
Other Positions
- Professor, Radiology, Boston University Chobanian & Avedisian School of Medicine
- Research Associate Professor, Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine
- Research Associate Professor, General Internal Medicine, Medicine, Boston University Chobanian & Avedisian School of Medicine
- Member, Whitaker Cardiovascular Institute, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Boston Medical Center
Education
- Indiana University Bloomington, PhD
- Juniata College, BS
Publications
- Published on 8/10/2023
Zheng A, Huang N, Bean D, Rayapaneni S, Deeney J, Sagar M, Hamilton JA. Resolvin E1 heals injured cardiomyocytes: Therapeutic implications and H-FABP as a readout for cardiovascular disease & systemic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2023 Oct; 197:102586. PMID: 37604082.
Read at: PubMed - Published on 12/22/2022
Taylor EN, Huang N, Lin S, Mortazavi F, Wedeen VJ, Siamwala JH, Gilbert RJ, Hamilton JA. Lipid and smooth muscle architectural pathology in the rabbit atherosclerotic vessel wall using Q-space cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2022 Dec 22; 24(1):74. PMID: 36544161.
Read at: PubMed - Published on 2/1/2021
Jayaraj A, Schwanz HA, Spencer DJ, Bhasin S, Hamilton JA, Jayaram B, Goldman AL, Krishna M, Krishnan M, Shah A, Jin Z, Krenzel E, Nair SN, Ramesh S, Guo W, Wagner G, Arthanari H, Peng L, Lawney B, Jasuja R. Allosterically Coupled Multisite Binding of Testosterone to Human Serum Albumin. Endocrinology. 2021 02 01; 162(2). PMID: 33125473.
Read at: PubMed - Published on 12/9/2020
Wang Y, Taylor E, Zikopoulos B, Seta F, Huang N, Hamilton JA, Kantak KM, Morgan KG. Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects. Neurobiol Aging. 2021 04; 100:39-47. PMID: 33477010.
Read at: PubMed - Published on 7/8/2020
Taylor EN, Huang N, Wisco J, Wang Y, Morgan KG, Hamilton JA. The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds. J Transl Med. 2020 07 08; 18(1):277. PMID: 32641073.
Read at: PubMed - Published on 2/26/2020
Jay AG, Simard JR, Huang N, Hamilton JA. SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect FA translocation. J Lipid Res. 2020 05; 61(5):790-807. PMID: 32102800.
Read at: PubMed - Published on 1/15/2019
Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM, Bidwell JP. Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E749-E772. PMID: 30645175.
Read at: PubMed - Published on 12/15/2018
Zeng B, Liao J, Zhang H, Fu S, Chen W, Pan G, Li Q, Chen W, Ferrone S, Wu B, Sun S, Hu J, Ahn MH, Lin Z, Yu D, Ou Z, Wang X, Mo F, Huang N, Hamilton JA, Li J, Fan S. Novel ANO5 mutation c.1067G>T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia. Head Neck. 2019 01; 41(1):230-238. PMID: 30554457.
Read at: PubMed - Published on 11/22/2018
Mitra R, Qiao J, Madhavan S, O'Neil GL, Ritchie B, Kulkarni P, Sridhar S, van de Ven AL, Kemmerling EMC, Ferris C, Hamilton JA, Ebong EE. The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation. Transl Med Commun. 2018; 3. PMID: 30957020.
Read at: PubMed - Published on 11/22/2018
Ronodeep Mitra, Ju Qiao, Sudharsan Madhavan, Gerard L. O’Neil, Bailey Ritchie, Praveen Kulkarni, Srinivas Sridhar, Anne L. van de Ven, Erica M. Cherry Kemmerling, Craig Ferris, James A. Hamilton and Eno E. Ebong. The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation. Translational Medicine Communications. 2018; 10(3).
View 216 more publications: View full profile at BUMC