XiaoYong Tong, MD, PhD

Assistant Professor, Medicine

(617) 414-1009
650 Albany St Evans Biomed Research Ctr

Biography

Diabetic patients have much higher morbidity and mortality of cardiovascular diseases including atherosclerosis and restenosis compared with other populations. Vascular smooth muscle cell (SMC) migration contributes significantly to these pathological processes. Generally SMCs stay quiescent in vasculature. When the endothelium layer is disrupted, the underlying SMCs migrate from media to intima and form the neointima. This process is accelerated in diabetes mellitus (DM). Nitric oxide (NO), the biologically active component of endothelium-derived relaxing factor, has critical roles in the maintenance of vascular homeostasis. Previous studies showed that NO reduces intracellular calcium, which causes relaxation and inhibits SMC growth and proliferation in native smooth muscle. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) plays a very important role in maintaining intracellular calcium level by uptaking calcium into SR/ER. Our previous studies showed that NO upregulated SERCA activity by S-glutathiolation of the most reactive thiol on cysteine-674 (C674) and inhibited SMC migration. My major focus is to study the mechanisms of cardiovascular dysfunction in diabetes, mainly focus on SERCA, NADPH oxidase and smooth muscle cell migration. Those studies can also be expanded to obesity, insulin resistance and metabolic symptoms.

Other Positions

  • Boston Medical Center

Education

  • Harbin Medical University, MD
  • Shanghai Institute of Materia Medica, PhD
  • Harbin Medical University, MS

Publications

  • Published on 8/17/2017

    Tong X, Hou X, Wason C, Kopel T, Cohen RA, Dember LM. Smooth Muscle Nitric Oxide Responsiveness and Clinical Maturation of Hemodialysis Arteriovenous Fistulae. Am J Pathol. 2017 Sep; 187(9):2095-2101. PMID: 28822538.

    Read at: PubMed
  • Published on 6/1/2016

    Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64. PMID: 26927696.

    Read at: PubMed
  • Published on 11/12/2015

    Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J, Cohen RA. Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):185-94. PMID: 26582463.

    Read at: PubMed
  • Published on 9/28/2014

    Mei Y, Thompson MD, Shiraishi Y, Cohen RA, Tong X. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. J Mol Cell Cardiol. 2014 Nov; 76:275-82. PMID: 25260714.

    Read at: PubMed
  • Published on 6/11/2014

    Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16. PMID: 24920669.

    Read at: PubMed
  • Published on 5/13/2014

    Mei Y, Thompson MD, Cohen RA, Tong X. Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta. 2015 Feb; 1852(2):243-51. PMID: 24834848.

    Read at: PubMed
  • Published on 3/11/2014

    Qin Z, Hou X, Weisbrod RM, Seta F, Cohen RA, Tong X. Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells. J Mol Cell Cardiol. 2014 Jul; 72:56-63. PMID: 24631774.

    Read at: PubMed
  • Published on 11/15/2013

    Mei Y, Thompson MD, Cohen RA, Tong X. Endoplasmic Reticulum Stress and Related Pathological Processes. J Pharmacol Biomed Anal. 2013 Nov 15; 1(2):1000107. PMID: 24611136.

    Read at: PubMed
  • Published on 8/20/2013

    Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug; 2(4):e000184. PMID: 23963753.

    Read at: PubMed
  • Published on 10/23/2012

    Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34. PMID: 23089226.

    Read at: PubMed

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