William A. Tyler

Assistant Professor, Anatomy & Neurobiology

(617) 638-4249
72 E. Concord St Instructional (L)


  • Pennsylvania State College of Medicine, PhD
  • Wake Forest University, BS


  • Published on 3/9/2017

    Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A. CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Neuron. 2017 Mar 22; 93(6):1344-1358.e5. PMID: 28285824.

    Read at: PubMed
  • Published on 2/25/2016

    Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. 2016 Mar 16; 89(6):1208-22. PMID: 26924435.

    Read at: PubMed
  • Published on 2/24/2016

    Olmos-Serrano JL, Tyler WA, Cabral HJ, Haydar TF. Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome. Exp Neurol. 2016 May; 279:40-56. PMID: 26854932.

    Read at: PubMed
  • Published on 4/15/2015

    Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52. PMID: 25878286.

    Read at: PubMed
  • Published on 3/20/2013

    Tyler WA, Haydar TF. Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome. J Neurosci. 2013 Mar 20; 33(12):5106-19. PMID: 23516277.

    Read at: PubMed
  • Published on 6/1/2012

    Ziegler AN, Schneider JS, Qin M, Tyler WA, Pintar JE, Fraidenraich D, Wood TL, Levison SW. IGF-II promotes stemness of neural restricted precursors. Stem Cells. 2012 Jun; 30(6):1265-76. PMID: 22593020.

    Read at: PubMed
  • Published on 8/19/2011

    Tyler WA, Jain MR, Cifelli SE, Li Q, Ku L, Feng Y, Li H, Wood TL. Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation. Glia. 2011 Nov; 59(11):1754-69. PMID: 21858874.

    Read at: PubMed
  • Published on 6/1/2010

    Tyler WA, Haydar TF. A new contribution to brain convolution: progenitor cell logistics during cortex development. Nat Neurosci. 2010 Jun; 13(6):656-7. PMID: 20498684.

    Read at: PubMed
  • Published on 5/13/2009

    Tyler WA, Gangoli N, Gokina P, Kim HA, Covey M, Levison SW, Wood TL. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci. 2009 May 13; 29(19):6367-78. PMID: 19439614.

    Read at: PubMed
  • Published on 9/8/2000

    Chernousov MA, Rothblum K, Tyler WA, Stahl RC, Carey DJ. Schwann cells synthesize type V collagen that contains a novel alpha 4 chain. Molecular cloning, biochemical characterization, and high affinity heparin binding of alpha 4(V) collagen. J Biol Chem. 2000 Sep 8; 275(36):28208-15. PMID: 10852920.

    Read at: PubMed

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