William Paul Duprex, PhD

Professor, Microbiology

William Duprex
617.638.4294

Biography

The overarching goal of my research program is to understand the molecular basis of paramyxovirus pathogenesis and attenuation with a view to translating this knowledge into the development and delivery of safe and efficacious vectored vaccines. I have over fifteen years experience as a molecular virologist and I and my laboratory have developed reverse genetics systems for both positive and negative strand RNA viruses. Currently my group focuses on respiratory paramyxoviruses.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • Queen's University Belfast, PhD
  • Queen's University Belfast, BS

Publications

  • Published on 7/1/2019

    Amarasinghe GK, Ayllón MA, Bào Y, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chabi-Jesus C, Chandran K, Chiapponi C, Crozier I, de Swart RL, Dietzgen RG, Dolnik O, Drexler JF, Dürrwald R, Dundon WG, Duprex WP, Dye JM, Easton AJ, Fooks AR, Formenty PBH, Fouchier RAM, Freitas-Astúa J, Griffiths A, Hewson R, Horie M, Hyndman TH, Jiang D, Kitajima EW, Kobinger GP, Kondo H, Kurath G, Kuzmin IV, Lamb RA, Lavazza A, Lee B, Lelli D, Leroy EM, Li J, Maes P, Marzano SL, Moreno A, Mühlberger E, Netesov SV, Nowotny N, Nylund A, Økland AL, Palacios G, Pályi B, Paweska JT, Payne SL, Prosperi A, Ramos-González PL, Rima BK, Rota P, Rubbenstroth D, Shi M, Simmonds P, Smither SJ, Sozzi E, Spann K, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, van den Hoogen B, Vasilakis N, Wahl V, Walker PJ, Wang LF, Whitfield AE, Williams JV, Zerbini FM, Zhang T, Zhang YZ, Kuhn JH. Taxonomy of the order Mononegavirales: update 2019. Arch Virol. 2019 Jul; 164(7):1967-1980. PMID: 31089958.

    Read at: PubMed
  • Published on 5/14/2019

    Anderson DE, Pfeffermann K, Kim SY, Sawatsky B, Pearson J, Kovtun M, Corcoran DL, Krebs Y, Sigmundsson K, Jamison SF, Yeo ZZJ, Rennick LJ, Wang LF, Talbot PJ, Duprex WP, Garcia-Blanco MA, von Messling V. Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae. MBio. 2019 05 14; 10(3). PMID: 31088929.

    Read at: PubMed
  • Published on 4/1/2019

    Maes P, Amarasinghe GK, Ayllón MA, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chandran K, Crozier I, de Swart RL, Dietzgen RG, Dolnik O, Domier LL, Drexler JF, Dürrwald R, Dundon WG, Duprex WP, Dye JM, Easton AJ, Fooks AR, Formenty PBH, Fouchier RAM, Freitas-Astúa J, Ghedin E, Griffiths A, Hewson R, Horie M, Hurwitz JL, Hyndman TH, Jiang D, Kobinger GP, Kondo H, Kurath G, Kuzmin IV, Lamb RA, Lee B, Leroy EM, Li J, Marzano SL, Mühlberger E, Netesov SV, Nowotny N, Palacios G, Pályi B, Paweska JT, Payne SL, Rima BK, Rota P, Rubbenstroth D, Simmonds P, Smither SJ, Song Q, Song T, Spann K, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, van den Hoogen B, Vasilakis N, Wahl V, Walker PJ, Wang D, Wang LF, Whitfield AE, Williams JV, Yè G, Zerbini FM, Zhang YZ, Kuhn JH. Taxonomy of the order Mononegavirales: second update 2018. Arch Virol. 2019 Apr; 164(4):1233-1244. PMID: 30663023.

    Read at: PubMed
  • Published on 12/19/2018

    Imperiale MJ, Blader I, Bradford P, D'Orazio S, Duprex WP, Ellermeier CD, Fernandez-Sesma A, McMahon K, Mitchell A, Pasetti MF, Tringe S. Completion of an Experiment. mSphere. 2018 12 19; 3(6). PMID: 30567903.

    Read at: PubMed
  • Published on 11/26/2018

    Beatty JA, Sharp CR, Duprex WP, Munday JS. Novel feline viruses: Emerging significance of gammaherpesvirus and morbillivirus infections. J Feline Med Surg. 2019 Jan; 21(1):5-11. PMID: 30472918.

    Read at: PubMed
  • Published on 5/9/2018

    Allen IV, McQuaid S, Penalva R, Ludlow M, Duprex WP, Rima BK. Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans. mSphere. 2018 May-Jun; 3(3). PMID: 29743202.

    Read at: PubMed
  • Published on 3/27/2018

    De Vries RD, Rennick LJ, Duprex WP, De Swart RL. Paramyxovirus Infections in Ex Vivo Lung Slice Cultures of Different Host Species. Methods Protoc. 2018 Mar 27; 1(2). PMID: 31164557.

    Read at: PubMed
  • Published on 1/1/2018

    Harris M, Duprex WP. Whether you are a virus or a learned society-based virology journal, evolution is critical for success! J Gen Virol. 2018 01; 99(1):1-2. PMID: 29347999.

    Read at: PubMed
  • Published on 8/1/2017

    de Swart RL, de Vries RD, Rennick LJ, van Amerongen G, McQuaid S, Verburgh RJ, Yüksel S, de Jong A, Lemon K, Nguyen DT, Ludlow M, Osterhaus ADME, Duprex WP. Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection. NPJ Vaccines. 2017; 2:22. PMID: 29263877.

    Read at: PubMed
  • Published on 7/12/2017

    Rissanen I, Ahmed AA, Azarm K, Beaty S, Hong P, Nambulli S, Duprex WP, Lee B, Bowden TA. Idiosyncratic Mòjiang virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses. Nat Commun. 2017 07 12; 8:16060. PMID: 28699636.

    Read at: PubMed

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