William Paul Duprex, PhD

Professor, Microbiology

William Duprex
617.638.4294

Biography

The overarching goal of my research program is to understand the molecular basis of paramyxovirus pathogenesis and attenuation with a view to translating this knowledge into the development and delivery of safe and efficacious vectored vaccines. I have over fifteen years experience as a molecular virologist and I and my laboratory have developed reverse genetics systems for both positive and negative strand RNA viruses. Currently my group focuses on respiratory paramyxoviruses.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences

Education

  • Queen's University Belfast, PhD
  • Queen's University Belfast, BS

Publications

  • Published on 5/9/2018

    Allen IV, McQuaid S, Penalva R, Ludlow M, Duprex WP, Rima BK. Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans. mSphere. 2018 May-Jun; 3(3). PMID: 29743202.

    Read at: PubMed
  • Published on 1/1/2018

    Harris M, Duprex WP. Whether you are a virus or a learned society-based virology journal, evolution is critical for success! J Gen Virol. 2018 Jan; 99(1):1-2. PMID: 29347999.

    Read at: PubMed
  • Published on 8/1/2017

    de Swart RL, de Vries RD, Rennick LJ, van Amerongen G, McQuaid S, Verburgh RJ, Yüksel S, de Jong A, Lemon K, Nguyen DT, Ludlow M, Osterhaus ADME, Duprex WP. Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection. NPJ Vaccines. 2017; 2:22. PMID: 29263877.

    Read at: PubMed
  • Published on 7/12/2017

    Rissanen I, Ahmed AA, Azarm K, Beaty S, Hong P, Nambulli S, Duprex WP, Lee B, Bowden TA. Idiosyncratic Mòjiang virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses. Nat Commun. 2017 Jul 12; 8:16060. PMID: 28699636.

    Read at: PubMed
  • Published on 5/8/2017

    de Vries RD, Ludlow M, de Jong A, Rennick LJ, Verburgh RJ, van Amerongen G, van Riel D, van Run PRWA, Herfst S, Kuiken T, Fouchier RAM, Osterhaus ADME, de Swart RL, Duprex WP. Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets. PLoS Pathog. 2017 May; 13(5):e1006371. PMID: 28481926.

    Read at: PubMed
  • Published on 3/29/2017

    Beaty SM, Park A, Won ST, Hong P, Lyons M, Vigant F, Freiberg AN, tenOever BR, Duprex WP, Lee B. Efficient and Robust Paramyxoviridae Reverse Genetics Systems. mSphere. 2017 Mar-Apr; 2(2). PMID: 28405630.

    Read at: PubMed
  • Published on 1/15/2017

    Beaty SM, Nachbagauer R, Hirsh A, Vigant F, Duehr J, Azarm KD, Stelfox AJ, Bowden TA, Duprex WP, Krammer F, Lee B. Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats. J Infect Dis. 2017 Jan 15; 215(2):209-213. PMID: 27811320.

    Read at: PubMed
  • Published on 10/21/2016

    Morfopoulou S, Mee ET, Connaughton SM, Brown JR, Gilmour K, Chong WK, Duprex WP, Ferguson D, Hubank M, Hutchinson C, Kaliakatsos M, McQuaid S, Paine S, Plagnol V, Ruis C, Virasami A, Zhan H, Jacques TS, Schepelmann S, Qasim W, Breuer J. Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis. Acta Neuropathol. 2017 Jan; 133(1):139-147. PMID: 27770235.

    Read at: PubMed
  • Published on 7/28/2016

    Laksono BM, de Vries RD, McQuaid S, Duprex WP, de Swart RL. Measles Virus Host Invasion and Pathogenesis. Viruses. 2016 Jul 28; 8(8). PMID: 27483301.

    Read at: PubMed
  • Published on 7/22/2016

    Hume AJ, Ames J, Rennick LJ, Duprex WP, Marzi A, Tonkiss J, Mühlberger E. Inactivation of RNA Viruses by Gamma Irradiation: A Study on Mitigating Factors. Viruses. 2016 Jul 22; 8(7). PMID: 27455307.

    Read at: PubMed

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