I receive my D.Sc. from the Technion in Israel studying the antibacterial activity of human polymorphonuclear neutrophil and the effect of the bacterial product on this process. During my post doctorate in the infectious department in BU I extended these studies to include the Fungicidal activity of both human polymorphonuclear neutrophils and human platelets using candida albicans hyphae and Aspergillus fumigatus as test organisms. In both studies I concentrated mainly on reactive oxygen species.
I used these expertise when I joined Millennium Pharmaceutical as a senior scientist in the antibacterial group and developed high throughput assays to detect antibacterial in collaborations with other companies using natural products.
Coming back to BU I joined the Pilch lab and studied the effect of Caveolins/caveolae in protecting adipocytes from fatty acid-mediated lipotoxicity by sequestering fatty acids on the cytoplasmic leaflet of the plasma membrane and augmenting triglyceride formation. In Barbara Corkey’s lab I started using human adipocytes and studied the Effects of Redox Couples on ROS Production and lipid turnover and the effect of food additives such as saccharine on the production of reactive oxygen species and the function of isolated beta cells, islets and adipocytes.
In the last few years I am the Assistant Co-director of the Adipose Tissue Biology and Nutrient Metabolism (ABM) core providing human peadipocytes and adipocytes as well as banked tissues. In addition we provide consultation to new investigators in the field.
- Research Assistant Professor, Endocrinology, Diabetes, Nutrition & Weight Management, Medicine, Boston University School of Medicine
- Technion - Israel Institute of Technology, PhD
- Technion - Israel Institute of Technology, MSc
- Bar-Ilan University, BSc
- Published on 12/23/2019
Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200. PMID: 31869355.
- Published on 10/14/2016
Jones Iv AR, Meshulam T, Oliveira MF, Burritt N, Corkey BE. Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes. PLoS One. 2016; 11(10):e0164011. PMID: 27741233.
- Published on 9/18/2015
Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70. PMID: 26629401.
- Published on 6/7/2011
Meshulam T, Breen MR, Liu L, Parton RG, Pilch PF. Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. J Lipid Res. 2011 Aug; 52(8):1526-32. PMID: 21652731.
- Published on 1/1/2011
Pilch PF, Meshulam T, Ding S, Liu L. Caveolae and lipid trafficking in adipocytes. Clin Lipidol. 2011; 6(1):49-58. PMID: 21625349.
- Published on 5/1/2010
Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22. PMID: 20388923.
- Published on 3/7/2006
Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 2006 Mar 7; 45(9):2882-93. PMID: 16503643.
- Published on 12/15/2005
Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors. J Med Chem. 2005 Dec 15; 48(25):7960-9. PMID: 16335920.
- Published on 2/7/2005
Wharton J, Meshulam T, Vallega G, Pilch P. Dissociation of insulin receptor expression and signaling from caveolin-1 expression. J Biol Chem. 2005 Apr 8; 280(14):13483-6. PMID: 15699039.
- Published on 3/1/1998
Christin L, Wysong DR, Meshulam T, Hastey R, Simons ER, Diamond RD. Human platelets damage Aspergillus fumigatus hyphae and may supplement killing by neutrophils. Infect Immun. 1998 Mar; 66(3):1181-9. PMID: 9488412.
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