Tova Meshulam, PhD

Research Assistant Professor, Biochemistry

617.358.4484
72 E. Concord Street K-6

Biography

I receive my D.Sc. from the Technion in Israel studying the antibacterial activity of human polymorphonuclear neutrophil and the effect of the bacterial product on this process. During my post doctorate in the infectious department in BU I extended these studies to include the Fungicidal activity of both human polymorphonuclear neutrophils and human platelets using candida albicans hyphae and Aspergillus fumigatus as test organisms. In both studies I concentrated mainly on reactive oxygen species.

I used these expertise when I joined Millennium Pharmaceutical as a senior scientist in the antibacterial group and developed high throughput assays to detect antibacterial in collaborations with other companies using natural products.

Coming back to BU I joined the Pilch lab and studied the effect of Caveolins/caveolae in protecting adipocytes from fatty acid-mediated lipotoxicity by sequestering fatty acids on the cytoplasmic leaflet of the plasma membrane and augmenting triglyceride formation. In Barbara Corkey’s lab I started using human adipocytes and studied the Effects of Redox Couples on ROS Production and lipid turnover and the effect of food additives such as saccharine on the production of reactive oxygen species and the function of isolated beta cells, islets and adipocytes.

In the last few years I am the Assistant Co-director of the Adipose Tissue Biology and Nutrient Metabolism (ABM) core providing human peadipocytes and adipocytes as well as banked tissues. In addition we provide consultation to new investigators in the field.

Other Positions

  • Research Assistant Professor, Endocrinology, Diabetes, Nutrition & Weight Management, Medicine, Boston University School of Medicine
  • Associate, Boston Nutrition Obesity Research Center, Boston University

Education

  • Technion - Israel Institute of Technology, PhD
  • Technion - Israel Institute of Technology, MSc
  • Bar-Ilan University, BSc

Publications

  • Published on 11/23/2021

    Jafari N, Kolla M, Meshulam T, Shafran JS, Qiu Y, Casey AN, Pompa IR, Ennis CS, Mazzeo CS, Rabhi N, Farmer SR, Denis GV. Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes. Sci Signal. 2021 11 23; 14(710):eabj2807. PMID: 34813359.

    Read at: PubMed
  • Published on 9/27/2021

    Istfan N, Hasson B, Apovian C, Meshulam T, Yu L, Anderson W, Corkey BE. Acute carbohydrate overfeeding: a redox model of insulin action and its impact on metabolic dysfunction in humans. Am J Physiol Endocrinol Metab. 2021 11 01; 321(5):E636-E651. PMID: 34569273.

    Read at: PubMed
  • Published on 8/24/2021

    Dance YW, Meshulam T, Seibel AJ, Obenreder MC, Layne MD, Nelson CM, Tien J. Adipose Stroma Accelerates the Invasion and Escape of Human Breast Cancer Cells from an Engineered Microtumor. Cell Mol Bioeng. 2022 Feb; 15(1):15-29. PMID: 35096184.

    Read at: PubMed
  • Published on 1/18/2021

    Batista ML, Meshulam T, Desevin K, Rabhi N, Farmer SR. Three-Dimensional Adipocyte Culture as a Model to Study Cachexia-Induced White Adipose Tissue Remodeling. J Vis Exp. 2021 01 18; (167). PMID: 33522508.

    Read at: PubMed
  • Published on 12/23/2019

    Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200. PMID: 31869355.

    Read at: PubMed
  • Published on 10/14/2016

    Jones Iv AR, Meshulam T, Oliveira MF, Burritt N, Corkey BE. Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes. PLoS One. 2016; 11(10):e0164011. PMID: 27741233.

    Read at: PubMed
  • Published on 9/18/2015

    Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70. PMID: 26629401.

    Read at: PubMed
  • Published on 6/7/2011

    Meshulam T, Breen MR, Liu L, Parton RG, Pilch PF. Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. J Lipid Res. 2011 Aug; 52(8):1526-32. PMID: 21652731.

    Read at: PubMed
  • Published on 1/1/2011

    Pilch PF, Meshulam T, Ding S, Liu L. Caveolae and lipid trafficking in adipocytes. Clin Lipidol. 2011; 6(1):49-58. PMID: 21625349.

    Read at: PubMed
  • Published on 5/1/2010

    Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22. PMID: 20388923.

    Read at: PubMed

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