Shakun Karki, PhD

Assistant Professor, Medicine

Shakuntala Karki
617.358.0012
72 E. Concord St Evans Building

Biography

Obesity represents the largest preventable health care problem in the United States. More than two third of deaths related to obesity worldwide are from cardiovascular cause. Pathological mechanisms that connect obesity with cardiovascular are incompletely understood. Dr. Karki’s research interests focuses on understanding the mechanisms of obesity induced diseases, including endothelial and vascular dysfunction, insulin-resistance and cardiovascular disease.

Education

  • Boston University School of Medicine, PhD

Publications

  • Published on 12/11/2017

    Zuriaga MA, Fuster JJ, Farb MG, MacLauchlan S, Bretón-Romero R, Karki S, Hess DT, Apovian CM, Hamburg NM, Gokce N, Walsh K. Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation. Sci Rep. 2017 Dec 11; 7(1):17326. PMID: 29229927.

    Read at: PubMed
  • Published on 9/29/2017

    Farb MG, Park SY, Karki S, Gokce N. Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy. J Vis Exp. 2017 Sep 29; (127). PMID: 28994775.

    Read at: PubMed
  • Published on 4/14/2017

    Karki S, Ngo DTM, Farb MG, Park SY, Saggese SM, Hamburg NM, Carmine B, Hess DT, Walsh K, Gokce N. WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. Am J Physiol Heart Circ Physiol. 2017 Jul 01; 313(1):H200-H206. PMID: 28411232.

    Read at: PubMed
  • Published on 9/28/2016

    Farb MG, Karki S, Park SY, Saggese SM, Carmine B, Hess DT, Apovian C, Fetterman JL, Bretón-Romero R, Hamburg NM, Fuster JJ, Zuriaga MA, Walsh K, Gokce N. WNT5A-JNK regulation of vascular insulin resistance in human obesity. Vasc Med. 2016 Dec; 21(6):489-496. PMID: 27688298.

    Read at: PubMed
  • Published on 11/18/2015

    Karki S, Farb MG, Myers S, Apovian C, Hess DT, Gokce N. Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans. Mediators Inflamm. 2015; 2015:106237. PMID: 26663986.

    Read at: PubMed
  • Published on 4/23/2015

    Karki S, Farb MG, Ngo DT, Myers S, Puri V, Hamburg NM, Carmine B, Hess DT, Gokce N. Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity. Arterioscler Thromb Vasc Biol. 2015 Jun; 35(6):1498-506. PMID: 25908760.

    Read at: PubMed
  • Published on 8/12/2014

    Ngo DT, Farb MG, Kikuchi R, Karki S, Tiwari S, Bigornia SJ, Bates DO, LaValley MP, Hamburg NM, Vita JA, Hess DT, Walsh K, Gokce N. Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity. Circulation. 2014 Sep 23; 130(13):1072-80. PMID: 25116954.

    Read at: PubMed
  • Published on 1/1/2014

    Karki S, Ngo DT, Bigornia S, Farb MG, Gokce N. . Exp Rev Endo & Metab. Insulin resistance: A key therapeutic target for cardiovascular risk reduction in obese patients. 2014.

  • Published on 9/4/2013

    Bigornia SJ, Farb MG, Tiwari S, Karki S, Hamburg NM, Vita JA, Hess DT, Lavalley MP, Apovian CM, Gokce N. Insulin status and vascular responses to weight loss in obesity. J Am Coll Cardiol. 2013 Dec 17; 62(24):2297-305. PMID: 23978693.

    Read at: PubMed
  • Published on 7/29/2013

    Farb MG, Tiwari S, Karki S, Ngo DT, Carmine B, Hess DT, Zuriaga MA, Walsh K, Fetterman JL, Hamburg NM, Vita JA, Apovian CM, Gokce N. Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity. Obesity (Silver Spring). 2014 Feb; 22(2):349-55. PMID: 23640904.

    Read at: PubMed

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