Seiko Ikezu, MD

Research Assistant Professor, Pharmacology & Experimental Therapeutics

Seiko Ikezu
617.358.5889
72 E. Concord St Instructional (L)

Websites

Education

  • Gunma University, MD
  • Gunma University, BS

Publications

  • Published on 9/15/2021

    Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci Transl Med. 2021 Sep 15; 13(611):eabe8455. PMID: 34524859.

    Read at: PubMed
  • Published on 9/1/2021

    Muraoka S, DeLeo AM, Yang Z, Tatebe H, Yukawa-Takamatsu K, Ikezu S, Tokuda T, Issadore D, Stern RA, Ikezu T. Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Aging Dis. 2021 Sep; 12(6):1363-1375. PMID: 34527415.

    Read at: PubMed
  • Published on 9/1/2021

    Muraoka S, Lin W, Takamatsu-Yukawa K, Hu J, Ikezu S, DeTure MA, Dickson DW, Emili A, Ikezu T. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging Dis. 2021 Sep; 12(6):1376-1388. PMID: 34527416.

    Read at: PubMed
  • Published on 7/1/2021

    Kalavai SV, Ikezu S. Neuritogenic function of microglia in maternal immune activation and autism spectrum disorders. Neural Regen Res. 2021 Jul; 16(7):1436-1437. PMID: 33318443.

    Read at: PubMed
  • Published on 4/14/2021

    Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 Apr 14; 16(1):24. PMID: 33853665.

    Read at: PubMed
  • Published on 3/22/2021

    Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 03 22; 16(1):18. PMID: 33752701.

    Read at: PubMed
  • Published on 2/12/2021

    Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain. 2021 02 12; 144(1):288-309. PMID: 33246331.

    Read at: PubMed
  • Published on 2/3/2021

    Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. J Proteome Res. 2021 03 05; 20(3):1733-1743. PMID: 33534581.

    Read at: PubMed
  • Published on 8/25/2020

    Muraoka S, Jedrychowski MP, Yanamandra K, Ikezu S, Gygi SP, Ikezu T. Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. Cells. 2020 08 25; 9(9). PMID: 32854315.

    Read at: PubMed
  • Published on 8/18/2020

    Ruan Z, Delpech JC, Venkatesan Kalavai S, Van Enoo AA, Hu J, Ikezu S, Ikezu T. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener. 2020 08 18; 15(1):47. PMID: 32811520.

    Read at: PubMed

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