My expertise is in understanding the pathogenesis of diabetic microvascular complications. In particular, studying the effect of high glucose in retinal endothelial cells, pericytes, and Muller cell gene expression.
- Professor, Endocrinology, Diabetes, Nutrition & Weight Management, Medicine, Boston University School of Medicine
- Boston Medical Center
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Boston University, PhD
- University of Kalyani, MS
- University of Kalyani, BS
- Published on 7/10/2020
Kim D, Sankaramoorthy A, Roy S. Downregulation of Drp1 and Fis1 Inhibits Mitochondrial Fission and Prevents High Glucose-Induced Apoptosis in Retinal Endothelial Cells. Cells. 2020 Jul 10; 9(7). PMID: 32664237.
- Published on 4/9/2020
Nguyen NH, Kim D, Roy S. High Glucose Increases Binding of Lysyl Oxidase to Extracellular Matrix Proteins: Implications for Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2020 Apr 09; 61(4):40. PMID: 32340032.
- Published on 9/21/2019
Subramanian ML, Stein TD, Siegel N, Ness S, Fiorello MG, Kim D, Roy S. Upregulation of Lysyl Oxidase Expression in Vitreous of Diabetic Subjects: Implications for Diabetic Retinopathy. Cells. 2019 09 21; 8(10). PMID: 31546618.
- Published on 9/16/2019
Kim D, Lee D, Trackman PC, Roy S. Effects of High Glucose-Induced Lysyl Oxidase Propeptide on Retinal Endothelial Cell Survival: Implications for Diabetic Retinopathy. Am J Pathol. 2019 10; 189(10):1945-1952. PMID: 31537300.
- Published on 9/1/2019
Roy S, Kim D, Sankaramoorthy A. Mitochondrial Structural Changes in the Pathogenesis of Diabetic Retinopathy. J Clin Med. 2019 Sep 01; 8(9). PMID: 31480638.
- Published on 8/7/2019
Daley EJ, Pajevic PD, Roy S, Trackman PC. Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus. JBMR Plus. 2019 Oct; 3(10):e10212. PMID: 31687648.
- Published on 5/6/2019
Kim D, Mecham RP, Nguyen NH, Roy S. Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy. Exp Eye Res. 2019 07; 184:221-226. PMID: 31022398.
- Published on 12/3/2018
Song B, Kim D, Nguyen NH, Roy S. Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2018 12 03; 59(15):5965-5972. PMID: 30550614.
- Published on 8/2/2018
Consigli A, Papanastasiou A, Roquelaure D, Wuarin R, Roy S, Thumann G, Chronopoulos A. [Changes in Retinal Vascular Caliber after Intravitreal Aflibercept Treatment for Diabetic Macular Oedema]. Klin Monbl Augenheilkd. 2019 Nov; 236(11):1318-1324. PMID: 30071565.
- Published on 5/9/2018
Kim D, Mouritzen U, Larsen BD, Roy S. Inhibition of Cx43 gap junction uncoupling prevents high glucose-induced apoptosis and reduces excess cell monolayer permeability in retinal vascular endothelial cells. Exp Eye Res. 2018 08; 173:85-90. PMID: 29750972.
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