The underlying theme of my research has been to explore structure – function relationships in the brain. To this end, my work has focused on uncovering the morphological changes in the brain that are responsible for the cognitive decline seen in aging and disease processes. In initial studies, I used developmental techniques to examine specific structure-function relationships in the memory system of non-human primates. I continued on to conduct studies of normal aging and cerebrovascular disease. In this work I have focused on characterize the cognitive changes taking place in non-human primate models. As my interests in studying the brain grew, I become involved in structural Magnetic Resonance Imaging (MRI) studies of normal aging and disorders such as Alzheimer’s disease. In this work I have been quantifying volumetric changes taking place in the brain in the course of the disease processes. This work continues to evolve and has changed focus somewhat in the recent years to include studies aimed at exploring the value of MRI in predicting which subjects will progress to develop cognitive decline and Alzheimer’s disease and which will remain cognitively stable.
- Associate Professor, Anatomy & Neurobiology, Boston University School of Medicine
- Associate Professor, Neurology, Boston University School of Medicine
- Associate Professor, Body Imaging, Radiology, Boston University School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Northeastern University, PhD
- University of Hartford, MA
- John Carroll University, BS
- Published on 8/5/2019
Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR, Goldstein LE, Cantu RC, Katz DI, Palmisano JN, Martin B, Cherry JD, Mahar I, Killiany RJ, McClean MD, Au R, Alvarez V, Stern RA, Mez J, McKee AC. Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy. JAMA Neurol. 2019 Aug 05. PMID: 31380975.
- Published on 7/27/2019
Puzo C, Labriola C, Sugarman MA, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Stein TD, Kowall NW, McKee AC, Mez J, Killiany RJ, Stern RA, Alosco ML. Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer's Coordinating Center Uniform Data Set. Alzheimers Res Ther. 2019 07 27; 11(1):64. PMID: 31351489.
- Published on 4/1/2019
Kubicki M, Baxi M, Pasternak O, Tang Y, Karmacharya S, Chunga N, Lyall AE, Rathi Y, Eckbo R, Bouix S, Mortazavi F, Papadimitriou G, Shenton ME, Westin CF, Killiany R, Makris N, Rosene DL. Lifespan Trajectories of White Matter Changes in Rhesus Monkeys. Cereb Cortex. 2019 04 01; 29(4):1584-1593. PMID: 29701751.
- Published on 3/18/2019
Zajac L, Burte H, Taylor HA, Killiany R. Self-reported navigation ability is associated with optic flow-sensitive regions' functional connectivity patterns during visual path integration. Brain Behav. 2019 04; 9(4):e01236. PMID: 30884216.
- Published on 3/7/2019
Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia. Alzheimers Dement. 2019 05; 15(5):686-698. PMID: 30852157.
- Published on 11/13/2018
Janulewicz P, Krengel M, Quinn E, Heeren T, Toomey R, Killiany R, Zundel C, Ajama J, O'Callaghan J, Steele L, Klimas N, Sullivan K. The Multiple Hit Hypothesis for Gulf War Illness: Self-Reported Chemical/Biological Weapons Exposure and Mild Traumatic Brain Injury. Brain Sci. 2018 Nov 13; 8(11). PMID: 30428552.
- Published on 8/1/2018
Taylor E, Huang N, Bodde J, Ellison A, Killiany R, Bachschmid MM, Hamilton J. MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits. J Transl Med. 2018 08 01; 16(1):215. PMID: 30068362.
- Published on 2/6/2018
Bauer CM, Cabral HJ, Killiany RJ. Multimodal Discrimination between Normal Aging, Mild Cognitive Impairment and Alzheimer's Disease and Prediction of Cognitive Decline. Diagnostics (Basel). 2018 Feb 06; 8(1). PMID: 29415470.
- Published on 1/1/2018
Alosco ML, Sugarman MA, Besser LM, Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA. A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2018; 63(4):1347-1360. PMID: 29843242.
- Published on 11/21/2017
Farrar DC, Mian AZ, Budson AE, Moss MB, Killiany RJ. Functional brain networks involved in decision-making under certain and uncertain conditions. Neuroradiology. 2018 Jan; 60(1):61-69. PMID: 29164280.
View 97 more publications: View full profile at BUMC