Robert C. Mercer, PhD

Publications

• Published on 11/29/2023

  Mercer RCC, Le NTT, Houser MCQ, Beeler AB, Harris DA. Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding. bioRxiv. 2023 Nov 29. PMID: 38077011.

  Read at: PubMed
• Published on 9/7/2022

  Mercer RCC, Harris DA. Mechanisms of prion-induced toxicity. Cell Tissue Res. 2023 Apr; 392(1):81-96. PMID: 36070155.

  Read at: PubMed
• Published on 1/23/2019

  Mercer RC, Harris DA. Identification of anti-prion drugs and targets using toxicity-based assays. Curr Opin Pharmacol. 2019 02; 44:20-27. PMID: 30684854.

  Read at: PubMed
• Published on 9/20/2018

  Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA. Prions activate a p38 MAPK synaptotoxic signaling pathway. PLoS Pathog. 2018 09; 14(9):e1007283. PMID: 30235355.

  Read at: PubMed
• Published on 1/16/2018

  Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, Jansen GH, Stepanova M, Sykes BD, Westaway D. A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles. PLoS Pathog. 2018 01; 14(1):e1006826. PMID: 29338055.

  Read at: PubMed
• Published on 3/1/2015

  Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D. Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation. EMBO Mol Med. 2015 Mar; 7(3):339-56. PMID: 25661904.

  Read at: PubMed
• Published on 12/23/2013

  Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D. Endoproteolytic processing of the mammalian prion glycoprotein family. FEBS J. 2014 Feb; 281(3):862-76. PMID: 24286250.

  Read at: PubMed
• Published on 11/13/2013

  Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013 Dec 27; 288(52):37241-55. PMID: 24225951.

  Read at: PubMed
• Published on 6/23/2011

  Mercer RC, Mudalige WA, Ige TO, Heeley DH. Vertebrate slow skeletal muscle actin - conservation, distribution and conformational flexibility. Biochim Biophys Acta. 2011 Oct; 1814(10):1253-60. PMID: 21722757.

  Read at: PubMed