Richard D. Wainford, PhD

Associate Professor, Pharmacology & Experimental Therapeutics

Richard Wainford
617.358.8238
700 Albany St Ctr for Adv Biomed Res

Biography

Background:
Dr Wainford obtained a Bachelors in Zoology from the University of Wales, Cardiff in 1999. Dr Wainford undertook his Graduate training in the Laboratory of Molecular Pharmacology and Toxicology in the Department of Medicine and Therapeutics at the University of Aberdeen School of Medicine under the guidance of Professor Hawksworth, earning a PhD in Molecular Pharmacology in 2004. Dr. Wainford then completed a 2-year post-doctoral fellowship in the Department of Pharmacology at the Louisiana State University Health Sciences Center in New Orleans in Cardiovascular & Renal Pharmacology under the mentorship of Dr. Kapusta. Dr. Wainford then became an Instructor of Pharmacology in 2008, remaining in the laboratory of Dr. Kapusta until his promotion to the rank of Assistant Professor in 2010. Dr. Wainford joined the Department of Pharmacology & Experimental Therapeutics at the Boston University School of Medicine and the Whitaker Cardiovascular Institute in 2011 as an Assistant Professor.

Research Summary:
Dr. Wainford is the director of the Laboratory of Cardio-Renal Research. Dr. Wainford’s research interests focus on the central neural control of fluid and electrolyte homeostasis and blood pressure regulation. Dr. Wainford’s laboratory utilizes an integrated physiological, pharmacological, molecular, and gene-targeting approach to investigate the anti-hypertensive role(s) of central G-alpha-subunit proteins in the endogenous GPCR-activated pathways that regulate central sympatheticoutflow, fluid and electrolyte homeostasis, and systemic blood pressure regulation in salt-resistant and salt-sensitive animal models.The major goal of Dr. Wainford’s research is identifying the underlying pathophysiology of and potential treatments for hypertension. Current studies concern the role of central G-alpha subunit protein gated pathways in mediating the neural control of kidney function and systemic arterial blood pressure.

Other Positions

  • Associate Professor, Cardiovascular Medicine, Medicine, Boston University School of Medicine
  • Member, Whitaker Cardiovascular Institute, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • University of Aberdeen, PhD
  • University of Wales, BS

Classes Taught

  • GMSPM701

Publications

  • Published on 6/1/2020

    Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, Ramirez A, Schlaich M, Stergiou GS, Tomaszewski M, Wainford RD, Williams B, Schutte AE. 2020 International Society of Hypertension global hypertension practice guidelines. J Hypertens. 2020 Jun; 38(6):982-1004. PMID: 32371787.

    Read at: PubMed
  • Published on 5/18/2020

    Beaney T, Schutte AE, Stergiou GS, Borghi C, Burger D, Charchar FJ, Cro S, Diaz AB, Damasceno A, Espeche WG, Jose AP, Khan NA, Kokubo Y, Maheshwari A, Marin MJ, More A, Neupane D, Nilsson PM, Patil M, Prabhakaran D, Ramirez AJ, Rodriguez PD, Schlaich MP, Steckelings UM, Tomaszewski M, Unger T, Wainford RD, Wang JG, Williams B, Poulter NR. May Measurement Month 2019: The Global Blood Pressure Screening Campaign of the International Society of Hypertension. Hypertension. 2020 May 18. PMID: 32419505.

    Read at: PubMed
  • Published on 5/6/2020

    Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, Ramirez A, Schlaich M, Stergiou GS, Tomaszewski M, Wainford RD, Williams B, Schutte AE. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020 Jun; 75(6):1334-1357. PMID: 32370572.

    Read at: PubMed
  • Published on 5/1/2020

    Kruger R, Brunström M, Burger D, Charchar F, Climie R, Mirabito Colafella KM, Kempny P, Korostovtseva L, Marques FZ, Picone D, Romero C, Steckelings UM, Velkoska E, Wainford R, Wynne BM, Zanuzzi MG. Highlights from the International Society of Hypertension's New Investigators Network during 2019. J Hypertens. 2020 May; 38(5):968-973. PMID: 32238785.

    Read at: PubMed
  • Published on 3/9/2020

    Carmichael CY, Kuwabara JT, Pascale CL, Moreira JD, Mahne SE, Kapusta DR, Rosene DL, Williams JS, Cunningham JT, Wainford RD. Hypothalamic Paraventricular Nucleus Gai2 (Guanine Nucleotide-Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein-Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure. Hypertension. 2020 Apr; 75(4):1002-1011. PMID: 32148128.

    Read at: PubMed
  • Published on 10/20/2019

    Moreira JD, Chaudhary P, Frame AA, Puleo F, Nist KM, Abkin EA, Moore TL, George JC, Wainford RD. Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gai2 protein-dependent, salt-sensitive hypertension. Exp Physiol. 2019 12; 104(12):1892-1910. PMID: 31631436.

    Read at: PubMed
  • Published on 10/14/2019

    Frame AA, Puleo F, Kim K, Walsh KR, Faudoa E, Hoover RS, Wainford RD. Sympathetic regulation of NCC in norepinephrine-evoked salt-sensitive hypertension in Sprague-Dawley rats. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1623-F1636. PMID: 31608673.

    Read at: PubMed
  • Published on 5/27/2019

    Frame AA, Carmichael CY, Kuwabara JT, Cunningham JT, Wainford RD. Role of the afferent renal nerves in sodium homeostasis and blood pressure regulation in rats. Exp Physiol. 2019 08; 104(8):1306-1323. PMID: 31074108.

    Read at: PubMed
  • Published on 4/24/2019

    Poulter NR, Borghi C, Castillo RR, Charchar FJ, Ramirez AJ, Schlaich MP, Schutte AE, Stergiou G, Unger T, Wainford RD, Beaney T. May Measurement Month 2017: Results of 39 national blood pressure screening programmes. Eur Heart J Suppl. 2019 Apr; 21(Suppl D):D1-D4. PMID: 31043862.

    Read at: PubMed
  • Published on 6/15/2018

    Zhang X, Frame AA, Williams JS, Wainford RD. GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study. Physiol Genomics. 2018 09 01; 50(9):724-725. PMID: 29906209.

    Read at: PubMed

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