Richard I. Near, PhD

Research Assistant Professor, Medicine

(617) 414-1826
650 Albany St Evans Biomed Research Ctr

Biography

Expertise includes: Molecular biology as applied to signal transduction in cancer; Mouse genetics; Lentiviral cloning and expression; Zinc finger proteins and RNA zipcodes.

Other Positions

  • Boston Medical Center

Education

  • University of Washington, PhD
  • University of Washington, MS
  • University of California, Irvine, BS
  • University of California, Irvine, BA

Publications

  • Published on 6/18/2012

    Makkinje A, Vanden Borre P, Near RI, Patel PS, Lerner A. Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas). J Biol Chem. 2012 Aug 10; 287(33):27703-14. PMID: 22711540.

    Read at: PubMed
  • Published on 1/22/2011

    Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal. 2011 Jun; 23(6):1030-40. PMID: 21262352.

    Read at: PubMed
  • Published on 5/18/2009

    Makkinje A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal. 2009 Sep; 21(9):1423-35. PMID: 19454314.

    Read at: PubMed
  • Published on 4/3/2009

    Near RI, Smith RS, Toselli PA, Freddo TF, Bloom AB, Vanden Borre P, Seldin DC, Lerner A. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009; 15:685-99. PMID: 19365570.

    Read at: PubMed
  • Published on 9/1/2007

    Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. J Cell Physiol. 2007 Sep; 212(3):655-65. PMID: 17427198.

    Read at: PubMed
  • Published on 1/1/2005

    Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res. 2005 Jan; 3(1):32-41. PMID: 15671247.

    Read at: PubMed
  • Published on 10/15/2003

    Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res. 2003 Oct 15; 63(20):6802-8. PMID: 14583477.

    Read at: PubMed
  • Published on 1/15/2003

    Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003 Jan 15; 170(2):969-78. PMID: 12517963.

    Read at: PubMed
  • Published on 2/1/2002

    Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A. Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. Clin Cancer Res. 2002 Feb; 8(2):589-95. PMID: 11839681.

    Read at: PubMed
  • Published on 9/1/2000

    Trombino AF, Near RI, Matulka RA, Yang S, Hafer LJ, Toselli PA, Kim DW, Rogers AE, Sonenshein GE, Sherr DH. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Breast Cancer Res Treat. 2000 Sep; 63(2):117-31. PMID: 11097088.

    Read at: PubMed

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