Orian S. Shirihai, MD, PhD

Adjunct Associate Professor, Medicine

Orian Shirihai
617.230.8570
650 Albany St Evans Biomed Research Ctr

Biography

Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Other Positions

  • Boston Medical Center
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Websites

Education

  • Technion - Israel Institute of Technology, MD
  • Technion - Israel Institute of Technology, PhD
  • Technion - Israel Institute of Technology, BSc

Publications

  • Published on 3/4/2020

    Wolf DM, Segawa M, Shirihai OS, Liesa M. Method for live-cell super-resolution imaging of mitochondrial cristae and quantification of submitochondrial membrane potentials. Methods Cell Biol. 2020; 155:545-555. PMID: 32183976.

    Read at: PubMed
  • Published on 2/18/2020

    Kondadi AK, Anand R, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS. Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner. EMBO Rep. 2020 Mar 04; 21(3):e49776. PMID: 32067344.

    Read at: PubMed
  • Published on 1/31/2020

    Cerqueira FM, Kozer N, Petcherski A, Baranovski BM, Wolf D, Assali EA, Roth Y, Gazit R, Barr H, Lewis EC, Las G, Shirihai OS. MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy. Biochem J. 2020 Jan 31; 477(2):461-475. PMID: 32003437.

    Read at: PubMed
  • Published on 1/7/2020

    Las G, Oliveira MF, Shirihai OS. Emerging roles of ß-cell mitochondria in type-2-diabetes. Mol Aspects Med. 2020 Feb; 71:100843. PMID: 31918997.

    Read at: PubMed
  • Published on 1/1/2020

    Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. PMID: 31896820.

    Read at: PubMed
  • Published on 11/18/2019

    Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels. Diabetes. 2020 Feb; 69(2):131-145. PMID: 31740442.

    Read at: PubMed
  • Published on 11/1/2019

    Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2019 Nov; 575(7783):E5. PMID: 31695192.

    Read at: PubMed
  • Published on 10/30/2019

    Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. PMID: 31666695.

    Read at: PubMed
  • Published on 10/14/2019

    Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019 11 15; 38(22):e101056. PMID: 31609012.

    Read at: PubMed
  • Published on 9/5/2019

    Kowaltowski AJ, Menezes-Filho SL, Assali EA, Gonçalves IG, Cabral-Costa JV, Abreu P, Miller N, Nolasco P, Laurindo FRM, Bruni-Cardoso A, Shirihai OS. Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis. FASEB J. 2019 Dec; 33(12):13176-13188. PMID: 31480917.

    Read at: PubMed

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