Orian S. Shirihai, MD, PhD

Adjunct Associate Professor, Medicine

Orian Shirihai
617.230.8570
650 Albany St Evans Biomed Research Ctr

Biography

Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Boston Medical Center

Education

  • Technion - Israel Institute of Technology, MD
  • Technion - Israel Institute of Technology, PhD
  • Technion - Israel Institute of Technology, BSc

Publications

  • Published on 7/25/2018

    Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 Oct; 16:150-159. PMID: 30098928.

    Read at: PubMed
  • Published on 7/10/2018

    Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. iScience. 2018 Jul 27; 5:99-109. PMID: 30240649.

    Read at: PubMed
  • Published on 6/28/2018

    Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. PMID: 29988332.

    Read at: PubMed
  • Published on 5/22/2018

    Liesa M, Shirihai OS. Mitochondrial adaptation in obesity is a ClpPicated business. EMBO Rep. 2018 Jun; 19(6). PMID: 29789387.

    Read at: PubMed
  • Published on 4/9/2018

    Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A. Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J. 2018 May 15; 37(10). PMID: 29632021.

    Read at: PubMed
  • Published on 4/3/2018

    Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 Apr 03; 27(4):869-885.e6. PMID: 29617645.

    Read at: PubMed
  • Published on 1/29/2018

    Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. Estrogen receptor a protects pancreatic ß-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 Mar 30; 293(13):4735-4751. PMID: 29378845.

    Read at: PubMed
  • Published on 11/15/2017

    Alsabeeh N, Chausse B, Kakimoto PA, Kowaltowski AJ, Shirihai O. Cell culture models of fatty acid overload: Problems and solutions. Biochim Biophys Acta. 2018 02; 1863(2):143-151. PMID: 29155055.

    Read at: PubMed
  • Published on 9/29/2017

    Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017; 16(21):2086-2099. PMID: 28820316.

    Read at: PubMed
  • Published on 6/13/2017

    Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I. Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):E5167-E5176. PMID: 28611221.

    Read at: PubMed

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