Orian S. Shirihai, MD, PhD

Adjunct Associate Professor, Medicine

Orian Shirihai
650 Albany St Evans Biomed Research Ctr

Biography

My laboratory is studying mitochondria in disease models including metabolic and cardiovascular. In the past ten years the lab has focused on the study of the interaction between mitochondria through fusion and fission events and the role of mitochondrial architecture in bioenergetics. The lab has established an array of assays for the study of islet mitochondrial bioenergetic functions. The lab is known for its development of key imaging approaches to quantify mitochondrial dynamics, motility and membrane potential. Using these methodologies to study mitochondrial dynamics we described the life cycle of the mitochondria, and the role of continuous fusion and fission dynamics in the maintenance of bioenergetic capacity and efficiency. The lab played a pivotal role in the development of cutting edge technology for high throughput respirometry in collaboration with Seahorse Bioscience. I am the founder of the mtARC (Mitochondria-Affinity Research Collaborative) which provides guidance in the mitochondrial science to the members of the Boston scientific community. The lab has trained over 10 post doctoral fellows, of which three have been recruited as faculty in academic institutions, and two are founders of new biotech companies.

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Boston Medical Center

Education

  • Technion - Israel Institute of Technology, MD
  • Technion - Israel Institute of Technology, PhD
  • Technion - Israel Institute of Technology, BSc

Publications

  • Published on 7/9/2022

    Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. TNFa-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci. 2022 Jul 09; 12(7). PMID: 35884707.

    Read at: PubMed
  • Published on 2/24/2022

    Petcherski A, Sharma M, Daskou M, Satta S, Vasilopoulos H, Hugo C, Ritou E, Dillon BJ, Fung E, Garcia G, Scafoglio C, Purkayastha A, Gomperts BN, Fishbein GA, Arumugaswami V, Liesa M, Shirihai OS, Kelesidis T. Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways. bioRxiv. 2022 Feb 24. PMID: 35233569.

    Read at: PubMed
  • Published on 12/1/2021

    Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST. The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells. Virulence. 2021 12; 12(1):2214-2227. PMID: 34494942.

    Read at: PubMed
  • Published on 11/23/2021

    Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. PMID: 34823065.

    Read at: PubMed
  • Published on 11/16/2021

    Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289. PMID: 34785772.

    Read at: PubMed
  • Published on 11/6/2021

    Brownstein AJ, Veliova M, Acin-Perez R, Liesa M, Shirihai OS. ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity. Rev Endocr Metab Disord. 2022 02; 23(1):121-131. PMID: 34741717.

    Read at: PubMed
  • Published on 9/17/2021

    Ngo J, Osto C, Villalobos F, Shirihai OS. Mitochondrial Heterogeneity in Metabolic Diseases. Biology (Basel). 2021 Sep 17; 10(9). PMID: 34571805.

    Read at: PubMed
  • Published on 9/10/2021

    Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L. Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives. Life (Basel). 2021 Sep 10; 11(9). PMID: 34575097.

    Read at: PubMed
  • Published on 8/31/2021

    Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 08 31; 36(9):109636. PMID: 34469722.

    Read at: PubMed
  • Published on 7/30/2021

    Acín-Perez R, Petcherski A, Veliova M, Benador IY, Assali EA, Colleluori G, Cinti S, Brownstein AJ, Baghdasarian S, Livhits MJ, Yeh MW, Krishnan KC, Vergnes L, Winn NC, Padilla J, Liesa M, Sacks HS, Shirihai OS. Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. Redox Biol. 2021 10; 46:102087. PMID: 34411987.

    Read at: PubMed

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