Dr. McComb is a Research Associate Professor of Biochemistry at Boston University School of Medicine (BUSM), is the Director of the NHLBI Cardiovascular Proteomics Center (CPC) Core Research Laboratory at BUSM and is a Faculty Member of the BUSM Center for Biomedical Mass Spectrometry (CBMS). Dr. McComb has authored/co-authored more than 50 peer-review publications, reviews and textbook chapters and has over 200 conference proceedings including many as invited speaker. Dr. McComb has served as a panel member on several National committees, has served on several NIH peer review study sections and is an expert reviewer for NIH, NCI and other organizations. Dr. McComb is an active member of the Human Proteome Organization (HUPO) whose mission is to characterize the human proteome. Dr. McComb’s research aims are directed towards the identification and characterization of differentially expressed proteins and differentially observed peptides and post-translational modifications (PTMs) associated with human disease. His laboratory focuses on applying mass spectrometry and proteomics technologies for the identification and characterization of proteins which may be perturbed by disease with the aim to identify patterns of changes in order to gain a global comprehensive understanding of disease progression. Identification of specific proteins and PTMs which change as a function of disease will lead to the development of diagnostic and prognostic biomarkers which will have tremendous clinical utility. Specific biomedical applications of research include cancer, Alzheimer’s disease, systemic amyloidosis, prion diseases, and cardiovascular disease.
- University Manitoba, PhD
- University Manitoba, MSc
- University Manitoba, BSc
- Published on 6/18/2018
Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon D, McComb ME, Manfredsson FP, Sortwell CE, Zaia J. Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway. Mol Cell Proteomics. 2018 Sep; 17(9):1778-1787. PMID: 29915149.
- Published on 7/31/2017
Saito Â, Souza EE, Costa FC, Meirelles GV, Gonçalves KA, Santos MT, Bressan GC, McComb ME, Costello CE, Whelan SA, Kobarg J. Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. J Proteome Res. 2017 Sep 01; 16(9):3147-3157. PMID: 28695742.
- Published on 6/6/2017
Khatri K, Klein JA, Haserick JR, Leon DR, Costello CE, McComb ME, Zaia J. Microfluidic Capillary Electrophoresis-Mass Spectrometry for Analysis of Monosaccharides, Oligosaccharides, and Glycopeptides. Anal Chem. 2017 Jun 20; 89(12):6645-6655. PMID: 28530388.
- Published on 6/2/2016
Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW. Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res. 2016 Jul 01; 15(7):2254-64. PMID: 27213235.
- Published on 5/26/2016
Zhang Z, Costa FC, Tan EP, Bushue N, DiTacchio L, Costello CE, McComb ME, Whelan SA, Peterson KR, Slawson C. O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2ß Protein at the A?-Globin Promoter. J Biol Chem. 2016 Jul 22; 291(30):15628-40. PMID: 27231347.
- Published on 4/18/2016
Lucena MC, Carvalho-Cruz P, Donadio JL, Oliveira IA, de Queiroz RM, Marinho-Carvalho MM, Sola-Penna M, de Paula IF, Gondim KC, McComb ME, Costello CE, Whelan SA, Todeschini AR, Dias WB. Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation. J Biol Chem. 2016 Jun 17; 291(25):12917-29. PMID: 27129262.
- Published on 12/7/2015
Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025. PMID: 26642319.
- Published on 8/24/2015
Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82. PMID: 26303906.
- Published on 5/22/2015
Théberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310. PMID: 26002792.
- Published on 2/15/2015
Yao C, Yu J, Taylor L, Polgar P, McComb ME, Costello CE. Protein Expression by Human Pulmonary Artery Smooth Muscle Cells Containing a BMPR2 Mutation and the Action of ET-1 as Determined by Proteomic Mass Spectrometry. Int J Mass Spectrom. 2015 Feb 15; 378:347-359. PMID: 25866469.
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