Lynne M. Coluccio, PhD

Associate Professor, Physiology & Biophysics

Lynne Coluccio
700 Albany St Ctr for Adv Biomed Res


Lynne Coluccio, PhD, joined the Department of Physiology & Biophysics at BUSM in 2013 as an Associate Professor after Boston Biomedical Research Institute (BBRI), where she had been a Senior Scientist, abruptly closed. While at BBRI, she played a variety of roles including chair of the Faculty Search Committee and a member of the Public Relations Committee. Throughout her career she has mentored dozens of students who have gone into academia, medicine, and teaching.


  • Rensselaer Polytechnic Institute, PhD
  • Rensselaer Polytechnic Institute, MS
  • State University of New York at Albany, BS

Classes Taught

  • GMSFC703
  • GMSPH730


  • Published on 4/7/2021

    Tokuo H, Komaba S, Coluccio LM. In pancreatic ß-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi. Mol Biol Cell. 2021 06 01; 32(12):1210-1220. PMID: 33826361.

    Read at: PubMed
  • Published on 1/1/2020

    Coluccio LM. Introduction. Adv Exp Med Biol. 2020; 1239:1-6. PMID: 32451852.

    Read at: PubMed
  • Published on 1/1/2020

    Coluccio LM. Myosins and Disease. Adv Exp Med Biol. 2020; 1239:245-316. PMID: 32451863.

    Read at: PubMed
  • Published on 7/11/2018

    Tokuo H, Bhawan J, Coluccio LM. Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018 Jul 11; 8(1):10449. PMID: 29993000.

    Read at: PubMed
  • Published on 9/11/2015

    Komaba S, Coluccio LM. Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells. PLoS One. 2015; 10(9):e0138012. PMID: 26361046.

    Read at: PubMed
  • Published on 7/17/2013

    Tokuo H, Coluccio LM. Myosin-1c regulates the dynamic stability of E-cadherin-based cell-cell contacts in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Sep; 24(18):2820-33. PMID: 23864705.

    Read at: PubMed
  • Published on 6/16/2011

    Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker HJ, Coluccio LM, Manstein DJ. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011 Aug 26; 286(34):29700-8. PMID: 21680745.

    Read at: PubMed
  • Published on 7/17/2010

    Adamek N, Geeves MA, Coluccio LM. Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin. Cell Mol Life Sci. 2011 Jan; 68(1):139-50. PMID: 20640478.

    Read at: PubMed
  • Published on 7/7/2010

    Komaba S, Coluccio LM. Localization of myosin 1b to actin protrusions requires phosphoinositide binding. J Biol Chem. 2010 Sep 3; 285(36):27686-93. PMID: 20610386.

    Read at: PubMed
  • Published on 2/9/2010

    Adamek N, Lieto-Trivedi A, Geeves MA, Coluccio LM. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Biochemistry. 2010 Feb 9; 49(5):958-71. PMID: 20039646.

    Read at: PubMed

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