Ludy Chen Shih, MD, MMSc, FAAN, FANA

Associate Professor, Neurology

Ludy Shih
617.638.5350

Biography

Dr. Shih has research interests in tremor and gait disorders in Parkinson’s disease (PD) and related movement disorders and their intersection with cognitive impairment and aging. She is interested in developing digital motor signatures, and has applied quantitative techniques to studying movement in both healthy and clinical populations, such as those who receive interventions such as deep brain stimulation (DBS) for PD and essential tremor (ET). Her work includes the use of wearable sensors and other objective methods to assess and characterize tremor, gait and related neurologic impairments in order to develop clinical and translational tools for detecting and managing these impairments. In addition, she is interested in the use of technology to improve access to care for vulnerable aging individuals with motor and cognitive impairment. Her investigator-initiated work has been funded by the Michael J. Fox Foundation and the Consortia for Improving Medicine with Innovation and Technology (CIMIT).

She has completed a Master’s degree in Clinical Investigation from the Harvard-MIT Health Sciences and Technology Clinical Investigator Training Program in collaboration with Pfizer and Merck & Co. While working in In biotech and pharma, she worked on multi-disciplinary teams on biomarker (fluid, imaging and wearable sensors), epidemiology, and natural history studies. Primarily focused on research and early development, she led clinical study design for several phase 1 and phase 2 studies, including the evaluation and selection of outcome assessments, including biomarker assessments and biostatistical innovation into protocol development, and was responsible for overall study execution and oversight. In addition, she has experience with both US and EU regulatory agency interactions, academic-industry partnerships through scientific collaborations, and evaluated external assets for in-licensing.

She currently serves on the Medical Advisory Board for the International Essential Tremor Foundation (IETF), the International Parkinson’s Disease and Movement Disorders Society (MDS) Tremor Study Group and previously served on the Steering Committee for the Registry for Advancement of Deep Brain Stimulation Therapy for Parkinson’s Disease (RAD-PD). She is a member of the Parkinson Study Group (PSG), Tremor Research Group (TRG), the MDS, and is a fellow of the American Academy of Neurology (AAN) and of the American Neurological Association (ANA).

Education

  • University of California, Los Angeles School of Medicine, MD
  • Massachusetts Institute of Technology, MMS/MMSc
  • Stanford University, BS

Publications

  • Published on 6/20/2022

    Qiu S, Miller MI, Joshi PS, Lee JC, Xue C, Ni Y, Wang Y, De Anda-Duran I, Hwang PH, Cramer JA, Dwyer BC, Hao H, Kaku MC, Kedar S, Lee PH, Mian AZ, Murman DL, O'Shea S, Paul AB, Saint-Hilaire MH, Alton Sartor E, Saxena AR, Shih LC, Small JE, Smith MJ, Swaminathan A, Takahashi CE, Taraschenko O, You H, Yuan J, Zhou Y, Zhu S, Alosco ML, Mez J, Stein TD, Poston KL, Au R, Kolachalama VB. Multimodal deep learning for Alzheimer's disease dementia assessment. Nat Commun. 2022 Jun 20; 13(1):3404. PMID: 35725739.

    Read at: PubMed
  • Published on 4/9/2022

    Cosentino S, Shih LC. Does essential tremor increase risk of cognitive impairment and dementia? Yes. Int Rev Neurobiol. 2022; 163:195-231. PMID: 35750363.

    Read at: PubMed
  • Published on 3/1/2021

    Fehlings MG, Chen Y, Aarabi B, Ahmad F, Anderson KD, Dumont T, Fourney DR, Harrop JS, Kim KD, Kwon BK, Lingam HK, Rizzo M, Shih LC, Tsai EC, Vaccaro A, McKerracher L. A Randomized Controlled Trial of Local Delivery of a Rho Inhibitor (VX-210) in Patients with Acute Traumatic Cervical Spinal Cord Injury. J Neurotrauma. 2021 08 01; 38(15):2065-2072. PMID: 33559524.

    Read at: PubMed
  • Published on 12/19/2019

    Schneider RB, Jimenez-Shahed J, Abraham DS, Thibault DP, Mantri S, Fullard M, Burack MA, Chou KL, Spindler M, Jermakowicz WJ, D'Haese PF, York MK, Kirk JC, Schwalb JM, Espay AJ, Shih LC, Simon DK, Hunter C, Crispo JAG, Willis AW. Acute readmission following deep brain stimulation surgery for Parkinson's disease: A nationwide analysis. Parkinsonism Relat Disord. 2020 01; 70:96-102. PMID: 31866156.

    Read at: PubMed
  • Published on 10/30/2019

    Joutsa J, Shih LC, Fox MD. Mapping holmes tremor circuit using the human brain connectome. Ann Neurol. 2019 12; 86(6):812-820. PMID: 31614012.

    Read at: PubMed
  • Published on 2/21/2019

    Broom L, Worley A, Gao F, Hernandez LD, Ashton CE, Shih LC, VanderHorst VG. Translational methods to detect asymmetries in temporal and spatial walking metrics in parkinsonian mouse models and human subjects with Parkinson's disease. Sci Rep. 2019 02 21; 9(1):2437. PMID: 30792396.

    Read at: PubMed
  • Published on 7/1/2018

    Joutsa J, Shih LC, Horn A, Reich MM, Wu O, Rost NS, Fox MD. Identifying therapeutic targets from spontaneous beneficial brain lesions. Ann Neurol. 2018 07; 84(1):153-157. PMID: 30014594.

    Read at: PubMed
  • Published on 3/1/2018

    Elble RJ, Shih L, Cozzens JW. Surgical treatments for essential tremor. Expert Rev Neurother. 2018 04; 18(4):303-321. PMID: 29475371.

    Read at: PubMed
  • Published on 11/23/2017

    Ondo W, Hashem V, LeWitt PA, Pahwa R, Shih L, Tarsy D, Zesiewicz T, Elble R. Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale. Mov Disord Clin Pract. 2018 Jan-Feb; 5(1):60-65. PMID: 30363460.

    Read at: PubMed
  • Published on 8/16/2017

    Beck CA, Beran DB, Biglan KM, Boyd CM, Dorsey ER, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Aldred J, Carter J, Fraser A, Jimenez-Shahed J, Hunter C, Spindler M, Reichwein S, Mari Z, Dunlop B, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Mejia NI, Bwala G, Nance M, Shih LC, Singer C, Vargas-Parra S, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Dhall R, Hassan A, DeMello S, Riggare SS, Wicks P, Achey MA, Elson MJ, Goldenthal S, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W. National randomized controlled trial of virtual house calls for Parkinson disease. Neurology. 2017 Sep 12; 89(11):1152-1161. PMID: 28814455.

    Read at: PubMed

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