Lucia Rameh Plant, PhD

Research Associate Professor, Medicine

(617) 638-6012
650 Albany St Evans Biomed Research Ctr

Biography

Studies in the Rameh Lab (http://sites.bu.edu/rameh-lab/) are aimed at understanding how phosphoinositide lipids affect different aspects of the diabetes/obesity cycle. As regulator of many cellular processes, such as vesicle trafficking and hormone signaling, phosphoinositide kinases are promising targets in the treatment of these diseases. The Rameh Lab is particularly interested in determining the role of the phosphoinositide PtdIns-5-P in pancreatic beta cell function. Recent data from the Lab show that PtdIns-5-P 4-kinases can regulate nutrient-independent TORC1 signaling that activates basal protein translation. They are currently investigating how these can impact basal insulin production and secretion in the pre-diabetic state. The Rameh Lab uses state-of-the art high performance liquid chromatography (HPLC) coupled to flow scintillation analysis to measure cellular phosphoinositides in cultured cells. They have recently developed a unique method for PtdIns-5-P detection that will aid future research on the cellular function of this lipid.

Websites

Education

  • Universidade de São Paulo, PhD
  • Universidade de São Paulo, BS

Publications

  • Published on 2/1/2016

    Rameh LE, Deeney JT. Phosphoinositide signalling in type 2 diabetes: a ß-cell perspective. Biochem Soc Trans. 2016 Feb; 44(1):293-8. PMID: 26862218.

    Read at: PubMed
  • Published on 1/1/2016

    Sarkes DA, Rameh LE. Analysis of the Phosphoinositide Composition of Subcellular Membrane Fractions. Methods Mol Biol. 2016; 1376:213-27. PMID: 26552687.

    Read at: PubMed
  • Published on 8/10/2015

    Toker A, Rameh L. PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K? Cancer Cell. 2015 Aug 10; 28(2):143-5. PMID: 26267528.

    Read at: PubMed
  • Published on 11/4/2014

    Mackey AM, Sarkes DA, Bettencourt I, Asara JM, Rameh LE. PIP4k? is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation. Sci Signal. 2014 Nov 04; 7(350):ra104. PMID: 25372051.

    Read at: PubMed
  • Published on 11/27/2013

    McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12; 504(7479):248-53. PMID: 24284631.

    Read at: PubMed
  • Published on 11/7/2013

    Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7; 155(4):844-57. PMID: 24209622.

    Read at: PubMed
  • Published on 6/11/2013

    Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal. 2013 Jun 11; 6(279):ra45. PMID: 23757022.

    Read at: PubMed
  • Published on 11/16/2012

    Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep. 2013 Jan; 14(1):57-64. PMID: 23154468.

    Read at: PubMed
  • Published on 3/6/2012

    Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012 Mar 30; 149(1):49-62. PMID: 22401813.

    Read at: PubMed
  • Published on 9/5/2010

    Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol. 2010 Oct; 11(10):920-7. PMID: 20818396.

    Read at: PubMed

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