Libin Liu, PhD

Research Assistant Professor, Pharmacology & Experimental Therapeutics

Libin Liu
617.358.4203
72 E. Concord St Silvio Conte (K)

Biography

White adipose tissue (WAT) is a highly dynamic organ and can respond rapidly to alterations in nutrient excess and deprivation, thereby fulfilling its major role in whole body energy homeostasis. Dysfunctional WAT leads to the etiology of a large number of metabolic disorders including type II diabetes and other metabolic syndrome. As the major cell type in WAT, a healthy, highly metabolic responsible adipocyte itself is essential in maintaining adipose tissue functions. However, it has been known that the functions of adipocyte start to fail under many pathophysiological conditions, such as obesity, metabolic stress, aging, lipodystrophy and others. The long term goal of my research is to understand what are the key factors and mechanisms that control adipocyte cellular functional set limit, beyond which WAT fails to function properly? To identify and characterize novel regulators, high throughput gene expression profiling, protein interaction mapping by proteomic mass spectrometry, CRISPR/RNAi screening and other systems-based approaches will be employed. My goal is to integrate the data obtained from these approaches and apply them back to in vivo mouse models. Studies for the molecular components and details of these regulatory machineries will help us to understand the mechanisms and factors that control adipocyte functional homeostasis, and furthermore to develop the potential biomarkers and drug targets for diagnosis, prognosis, and therapy to improve adipocyte quality and treat human obesity related metabolic diseases.

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University

Education

  • Gunma University, PhD
  • China Medical University, MB

Publications

  • Published on 12/15/2020

    Wang H, Wan X, Pilch PF, Ellisen LW, Fried SK, Liu L. An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming. Elife. 2020 12 15; 9. PMID: 33320092.

    Read at: PubMed
  • Published on 2/28/2020

    Liu L. Lessons from cavin-1 deficiency. Biochem Soc Trans. 2020 02 28; 48(1):147-154. PMID: 31922193.

    Read at: PubMed
  • Published on 5/24/2019

    Wang H, Pilch PF, Liu L. Cavin-1/PTRF mediates insulin-dependent focal adhesion remodeling and ameliorates high-fat diet-induced inflammatory responses in mice. J Biol Chem. 2019 07 05; 294(27):10544-10552. PMID: 31126986.

    Read at: PubMed
  • Published on 1/12/2018

    Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM. Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nat Commun. 2018 01 12; 9(1):168. PMID: 29330478.

    Read at: PubMed
  • Published on 3/9/2017

    Ding SY, Liu L, Pilch PF. Muscular dystrophy in PTFR/cavin-1 null mice. JCI Insight. 2017 03 09; 2(5):e91023. PMID: 28289716.

    Read at: PubMed
  • Published on 12/13/2016

    Wang H, Liu L, Lin JZ, Aprahamian TR, Farmer SR. Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes. Cell Metab. 2016 Dec 13; 24(6):835-847. PMID: 27974179.

    Read at: PubMed
  • Published on 8/16/2016

    Liu L, Pilch PF. PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. Elife. 2016 Aug 16; 5. PMID: 27528195.

    Read at: PubMed
  • Published on 9/18/2015

    Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70. PMID: 26629401.

    Read at: PubMed
  • Published on 7/18/2014

    Liu L, Hansen CG, Honeyman BJ, Nichols BJ, Pilch PF. Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. PLoS One. 2014; 9(7):e102935. PMID: 25036884.

    Read at: PubMed
  • Published on 2/7/2014

    Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21; 289(12):8473-83. PMID: 24509860.

    Read at: PubMed

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