White adipose tissue (WAT) is a highly dynamic organ and can respond rapidly to alterations in nutrient excess and deprivation, thereby fulfilling its major role in whole body energy homeostasis. Dysfunctional WAT leads to the etiology of a large number of metabolic disorders including the metabolic syndrome and type II diabetes. As the major cell type in WAT, a healthy, highly metabolic responsible adipocyte itself is essential in maintaining adipose tissue functions. However, it has been known that the functions of adipocyte start to fail under many physiological (such as aging) and pathological (obesity, metabolic stress and lipodystrophy) conditions. We are trying to ask the questions about: what are the key factors and mechanisms that control adipocyte functional set limit beyond which WAT fails to function properly? One of our recent studies has shown the capacity of adipocyte ribosome biogenesis which is controlled by ribosomal transcription determines the maximal limit of functional homeostasis. Further studies for the components and mechanism details of this regulatory machinery will help us not only to understand the importance of the ribosome biogenesis for adipocyte physiology, but also to develop the potential biomarkers and drug targets for diagnosis, prognosis, and therapy in human obesity.
- Gunma University, PhD
- China Medical University, MB
- Published on 3/9/2017
Ding SY, Liu L, Pilch PF. Muscular dystrophy in PTFR/cavin-1 null mice. JCI Insight. 2017 03 09; 2(5):e91023. PMID: 28289716.
- Published on 12/13/2016
Wang H, Liu L, Lin JZ, Aprahamian TR, Farmer SR. Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes. Cell Metab. 2016 Dec 13; 24(6):835-847. PMID: 27974179.
- Published on 8/16/2016
Liu L, Pilch PF. PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. Elife. 2016 Aug 16; 5. PMID: 27528195.
- Published on 9/18/2015
Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70. PMID: 26629401.
- Published on 7/18/2014
Liu L, Hansen CG, Honeyman BJ, Nichols BJ, Pilch PF. Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. PLoS One. 2014; 9(7):e102935. PMID: 25036884.
- Published on 2/7/2014
Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21; 289(12):8473-83. PMID: 24509860.
- Published on 4/25/2013
Govender P, Romero F, Shah D, Paez J, Ding SY, Liu L, Gower A, Baez E, Aly SS, Pilch P, Summer R. Cavin1; a regulator of lung function and macrophage phenotype. PLoS One. 2013; 8(4):e62045. PMID: 23634221.
- Published on 6/7/2011
Meshulam T, Breen MR, Liu L, Parton RG, Pilch PF. Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. J Lipid Res. 2011 Aug; 52(8):1526-32. PMID: 21652731.
- Published on 5/17/2011
Pilch PF, Liu L. Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes. Trends Endocrinol Metab. 2011 Aug; 22(8):318-24. PMID: 21592817.
- Published on 1/1/2011
Pilch PF, Meshulam T, Ding S, Liu L. Caveolae and lipid trafficking in adipocytes. Clin Lipidol. 2011; 6(1):49-58. PMID: 21625349.
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