Dr. Cacicedo’s research interests are two-fold 1) the study of macro- and micro-vascular complications caused by diabetes and obesity and 2) the actions of exercise on the vascular wall. Low grade vascular inflammation is an underlying cause of atherosclerotic cardiovascular disease (ASCVD) and physical exercise has been demonstrated to prevent and improve ASCVD and vascular function in patients with and without diabetes. This is evident even in the absence of overt weight loss. Exercise can also help in the control and maintenance of blood glucose levels which is key to the prevention of diabetic microvascular complications such as retinopathy. Thus, an overarching theme to his research is to discover the mechanism(s) of exercise-induced anti-inflammatory actions on the vasculature and determine whether they can be replicated pharmacologically. Discoveries of this nature could serve as critical therapeutics or preventative therapies for vascular disorders associated with diabetes and obesity.
Dr. Cacicedo earned his PhD in the Department of Pathology and Laboratory Medicine at Boston University School of Medicine (BUSM) and is currently an Assistant Professor in the Department of Medicine, Section of Endocrinology at BUSM.
- Boston Medical Center
- Boston University School of Medicine, PhD
- Boston University, MA
- Boston University, BA
- Published on 7/14/2017
Salma N, Song JS, Kawakami A, Devi SP, Khaled M, Cacicedo JM, Fisher DE. Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor ?2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice. Mol Cell Biol. 2017 Aug 01; 37(15). PMID: 28483914.
- Published on 7/14/2017
Lan F, Weikel KA, Cacicedo JM, Ido Y. Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients. 2017 Jul 14; 9(7). PMID: 28708087.
- Published on 9/16/2016
Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3ß increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Oct; 36(5). PMID: 27534430.
- Published on 1/14/2016
Weikel KA, Ruderman NB, Cacicedo JM. Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism. 2016 May; 65(5):634-45. PMID: 27085772.
- Published on 10/29/2014
Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol. 2015 Feb 1; 308(3):C249-63. PMID: 25354528.
- Published on 5/16/2014
Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One. 2014; 9(5):e97554. PMID: 24835252.
- Published on 7/1/2013
Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013 Jul 1; 123(7):2764-72. PMID: 23863634.
- Published on 4/13/2012
Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One. 2012; 7(4):e35092. PMID: 22514710.
- Published on 2/29/2012
Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13. PMID: 22378745.
- Published on 2/8/2012
Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801. PMID: 22323564.
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