Jose M. Cacicedo, PhD

Assistant Professor, Medicine

Jose Cacicedo
(617) 638-7033
650 Albany St Evans Biomed Research Ctr

Biography

Dr. Cacicedo’s research interests are two-fold 1) the study of macro- and micro-vascular complications caused by diabetes and obesity and 2) the actions of exercise on the vascular wall. Low grade vascular inflammation is an underlying cause of atherosclerotic cardiovascular disease (ASCVD) and physical exercise has been demonstrated to prevent and improve ASCVD and vascular function in patients with and without diabetes. This is evident even in the absence of overt weight loss. Exercise can also help in the control and maintenance of blood glucose levels which is key to the prevention of diabetic microvascular complications such as retinopathy. Thus, an overarching theme to his research is to discover the mechanism(s) of exercise-induced anti-inflammatory actions on the vasculature and determine whether they can be replicated pharmacologically. Discoveries of this nature could serve as critical therapeutics or preventative therapies for vascular disorders associated with diabetes and obesity.

Dr. Cacicedo earned his PhD in the Department of Pathology and Laboratory Medicine at Boston University School of Medicine (BUSM) and is currently an Assistant Professor in the Department of Medicine, Section of Endocrinology at BUSM.

Other Positions

  • Boston Medical Center

Education

  • Boston University School of Medicine, PhD
  • Boston University, MA
  • Boston University, BA

Publications

  • Published on 7/14/2017

    Salma N, Song JS, Kawakami A, Devi SP, Khaled M, Cacicedo JM, Fisher DE. Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor ?2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice. Mol Cell Biol. 2017 Aug 01; 37(15). PMID: 28483914.

    Read at: PubMed
  • Published on 7/14/2017

    Lan F, Weikel KA, Cacicedo JM, Ido Y. Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients. 2017 Jul 14; 9(7). PMID: 28708087.

    Read at: PubMed
  • Published on 9/16/2016

    Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3ß increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Oct; 36(5). PMID: 27534430.

    Read at: PubMed
  • Published on 1/14/2016

    Weikel KA, Ruderman NB, Cacicedo JM. Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism. 2016 May; 65(5):634-45. PMID: 27085772.

    Read at: PubMed
  • Published on 10/29/2014

    Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol. 2015 Feb 1; 308(3):C249-63. PMID: 25354528.

    Read at: PubMed
  • Published on 5/16/2014

    Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One. 2014; 9(5):e97554. PMID: 24835252.

    Read at: PubMed
  • Published on 7/1/2013

    Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013 Jul 1; 123(7):2764-72. PMID: 23863634.

    Read at: PubMed
  • Published on 4/13/2012

    Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One. 2012; 7(4):e35092. PMID: 22514710.

    Read at: PubMed
  • Published on 2/29/2012

    Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13. PMID: 22378745.

    Read at: PubMed
  • Published on 2/8/2012

    Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801. PMID: 22323564.

    Read at: PubMed

View 9 more publications: View full profile at BUMC

View all profiles