Our focus is to develop novel optical techniques for fundamental research and clinical applications. The research includes the development of inverse spectroscopic optical coherence tomography (ISOCT) and metabolic optical coherence tomography applicable in vivo, with ISOCT being sensitive to nanoscale tissue structural changes and metabolic OCT being able to quantify tissue oxygen metabolism. In addition, we also develop methods for label-free optical angiography on live animals. We are also interested in novel optical endoscopy, super resolution microscopy for fundamental science, biosensing and computational optics. The clinical applications encompass cancer early detection, eye diseases such as glaucoma, and aging diseases etc.
- Northwestern University, PhD
- Northwestern University, MS
- Tsinghua University, BS
- Published on 7/9/2019
Song W, Fu S, Song S, Zhang S, Zhang L, Ness S, Desai M, Yi J. Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model. Neurophotonics. 2019 Oct; 6(4):041103. PMID: 31312670.
- Published on 5/8/2019
Lee HJ, Zhang L, Zhang S, Yi J. Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence. Transl Vis Sci Technol. 2019 May; 8(3):16. PMID: 31114716.
- Published on 8/4/2018
Song W, Zhou L, Yi J. Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT). J Vis Exp. 2018 08 04; (138). PMID: 30124648.
- Published on 6/28/2018
Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 11; 11(11):e201800053. PMID: 29855165.
- Published on 6/28/2018
Song W, Zhou L, Zhang S, Ness S, Desai M, Yi J. Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina. Biomed Opt Express. 2018 Jul 01; 9(7):3464-3480. PMID: 29984110.
- Published on 12/4/2017
Zhang L, Song W, Shao D, Zhang S, Desai M, Ness S, Roy S, Yi J. Volumetric fluorescence retinal imaging in vivo over a 30-degree field of view by oblique scanning laser ophthalmoscopy (oSLO). Biomed Opt Express. 2018 01 01; 9(1):25-40. PMID: 29359085.
- Published on 8/17/2017
Zhang L, Capilla A, Song W, Mostoslavsky G, Yi J. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan. Sci Rep. 2017 08 17; 7(1):8591. PMID: 28819250.
- Published on 8/7/2017
Song W, Zhang L, Ness S, Yi J. Wavelength-dependent optical properties of melanosomes in retinal pigmented epithelium and their changes with melanin bleaching: a numerical study. Biomed Opt Express. 2017 Sep 01; 8(9):3966-3980. PMID: 29026682.
- Published on 12/1/2015
Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 1; 109(11):2218-26. PMID: 26636933.
- Published on 9/25/2015
Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Amani A. Fawzi, Robert A. Linsenmeier, and Hao F. Zhang. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation. Light: Science & Applications. 2015; e334(4).
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