Our focus is to develop novel optical techniques for fundamental research and clinical applications. The research includes the development of inverse spectroscopic optical coherence tomography (ISOCT) and metabolic optical coherence tomography applicable in vivo, with ISOCT being sensitive to nanoscale tissue structural changes and metabolic OCT being able to quantify tissue oxygen metabolism. In addition, we also develop methods for label-free optical angiography on live animals. We are also interested in novel optical endoscopy, super resolution microscopy for fundamental science, biosensing and computational optics. The clinical applications encompass cancer early detection, eye diseases such as glaucoma, and aging diseases etc.
- Northwestern University, PhD
- Northwestern University, MS
- Tsinghua University, BS
- Published on 8/17/2017
Zhang L, Capilla A, Song W, Mostoslavsky G, Yi J. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan. Sci Rep. 2017 Aug 17; 7(1):8591. PMID: 28819250.
- Published on 8/7/2017
Song W, Zhang L, Ness S, Yi J. Wavelength-dependent optical properties of melanosomes in retinal pigmented epithelium and their changes with melanin bleaching: a numerical study. Biomed Opt Express. 2017 Sep 01; 8(9):3966-3980. PMID: 29026682.
- Published on 12/1/2015
Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 1; 109(11):2218-26. PMID: 26636933.
- Published on 9/25/2015
Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Amani A. Fawzi, Robert A. Linsenmeier, and Hao F. Zhang. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation. Light: Science & Applications. 2015; e334(4).
- Published on 9/8/2015
Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. In vivo capture and label-free detection of early metastatic cells. Nat Commun. 2015; 6:8094. PMID: 26348915.
- Published on 9/1/2015
Ji Yi, Siyu Chen, Xiao Shu, Amani A. Fawzi, and Hao F. Zhang. Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy. Biomed. Opt. Express. 2015; 6(10):3701-3713.
- Published on 9/1/2015
Liu W, Yi J, Chen S, Jiao S, Zhang HF. Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length. Med Phys. 2015 Sep; 42(9):5356-62. PMID: 26328984.
- Published on 7/10/2015
Chen S, Yi J, Zhang HF. Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography. Biomed Opt Express. 2015 Aug 1; 6(8):2840-53. PMID: 26309748.
- Published on 4/7/2015
Urban BE, Yi J, Chen S, Dong B, Zhu Y, DeVries SH, Backman V, Zhang HF. Super-resolution two-photon microscopy via scanning patterned illumination. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Apr; 91(4):042703. PMID: 25974523.
- Published on 2/26/2015
Chen H, Zhao Y, Liu M, Feng L, Puyang Z, Yi J, Liang P, Zhang HF, Cang J, Troy JB, Liu X. Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1971-84. PMID: 25722210.
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