Dr. Snyder-Cappione received her B.S. from Brandeis University and her Ph.D. from the University of Rochester Medical Center. Her doctoral research focus was the regulation of IFN-gamma and cytotoxic effector functions by CD8+ T cells. During her post-doctoral work at UCSF, she investigated the role of iNKT cells in HIV and Mycobacterium tuberculosis infections as well as sarcoidosis. Her current research interests include: (1) determining the diagnostic and prognostic potential of ex vivo immune functional profiling in human inflammatory diseases, (2) investigating the differentiation potential and lineage relationships of iNKT cell subsets, and (3) elucidating the role of T cell and iNKT cell exhaustion in the progression of infectious diseases and cancer.
- Member, BU-BMC Cancer Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Director, Flow Cytometry Core Facility, Boston University School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- University of Rochester School of Medicine & Dentistry, PhD
- University of Rochester School of Medicine & Dentistry, MS
- Brandeis University, BS
- Published on 6/4/2021
Olson A, Coote C, Snyder-Cappione JE, Lin N, Sagar M. HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation. J Infect Dis. 2021 Jun 04; 223(11):1934-1942. PMID: 33075121.
- Published on 4/9/2021
Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676. PMID: 33897682.
- Published on 5/12/2020
Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020 07 07; 32(1):44-55.e6. PMID: 32402267.
- Published on 3/18/2020
Belkina AC, Azer M, Lee JJ, Elgaali HH, Pihl R, Cleveland M, Carr J, Kim S, Habib C, Hasturk H, Snyder-Cappione JE, Nikolajczyk BS. Single-Cell Analysis of the Periodontal Immune Niche in Type 2 Diabetes. J Dent Res. 2020 07; 99(7):855-862. PMID: 32186942.
- Published on 11/28/2019
Belkina AC, Ciccolella CO, Anno R, Halpert R, Spidlen J, Snyder-Cappione JE. Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets. Nat Commun. 2019 11 28; 10(1):5415. PMID: 31780669.
- Published on 12/5/2018
Belkina AC, Starchenko A, Drake KA, Proctor EA, Pihl RMF, Olson A, Lauffenburger DA, Lin N, Snyder-Cappione JE. Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging. Front Immunol. 2018; 9:2783. PMID: 30568654.
- Published on 10/24/2018
Elias R, Hartshorn K, Rahma O, Lin N, Snyder-Cappione JE. Aging,?immune senescence,?and immunotherapy:?A comprehensive review. Semin Oncol. 2018 08; 45(4):187-200. PMID: 30539714.
- Published on 8/27/2018
Akiyama H, Miller CM, Ettinger CR, Belkina AC, Snyder-Cappione JE, Gummuluru S. HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction. Nat Commun. 2018 08 27; 9(1):3450. PMID: 30150664.
- Published on 7/20/2018
Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54. PMID: 30029671.
- Published on 3/7/2018
Fleury M, Belkina AC, Proctor EA, Zammitti C, Simms RW, Lauffenburger DA, Snyder-Cappione JE, Lafyatis R, Dooms H. Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis. Arthritis Rheumatol. 2018 04; 70(4):566-577. PMID: 29245183.
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