Jason Randall Rock, PhD

Associate Professor, Medicine

Jason Rock
617.358.0798
670 Albany Street

Biography

Jason Rock, PhD, is an Associate Professor of Medicine at the Chobanian and Avedisian School of Medicine. The Rock Lab in the Center for Regenerative Medicine studies how the many different cell types of our lungs are generated during development and how they respond to normal wear and tear, acute injury and disease. The underlying hypothesis is that aberrant (stem) cell behaviors explain many features of lung diseases such as chronic obstructive pulmonary disease, cystic fibrosis, asthma, and pulmonary fibrosis. We use in vivo and in vitro models to identify and test the progenitor capacity of putative stem cell populations and the molecular mechanisms and environmental influences (i.e., niches) that regulate their proliferation and differentiation. Our ultimate goal is to identify genetic, molecular and cellular therapies for the treatment of lung disease.

Other Positions

  • Faculty, National Emerging Infectious Disease Lab, Boston University
  • Member, Pulmonary Center, Boston University
  • Member, Center for Regenerative Medicine, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • University of Florida College of Medicine, PhD
  • Florida State University - Tallahassee, BS

Classes Taught

  • GMSMM725

Publications

  • Published on 5/2/2022

    Korte N, Ilkan Z, Pearson CL, Pfeiffer T, Singhal P, Rock JR, Sethi H, Gill D, Attwell D, Tammaro P. The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia. J Clin Invest. 2022 May 02; 132(9). PMID: 35316222.

    Read at: PubMed
  • Published on 3/30/2022

    Kadur Lakshminarasimha Murthy P, Sontake V, Tata A, Kobayashi Y, Macadlo L, Okuda K, Conchola AS, Nakano S, Gregory S, Miller LA, Spence JR, Engelhardt JF, Boucher RC, Rock JR, Randell SH, Tata PR. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Nature. 2022 Apr; 604(7904):111-119. PMID: 35355018.

    Read at: PubMed
  • Published on 9/15/2021

    Hernandez-Clavijo A, Sarno N, Gonzalez-Velandia KY, Degen R, Fleck D, Rock JR, Spehr M, Menini A, Pifferi S. TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons. eNeuro. 2021 Sep-Oct; 8(5). PMID: 34433575.

    Read at: PubMed
  • Published on 12/29/2020

    Engler AE, Ysasi AB, Pihl RMF, Villacorta-Martin C, Heston HM, Richardson HMK, Thapa BR, Moniz NR, Belkina AC, Mazzilli SA, Rock JR. Airway-Associated Macrophages in Homeostasis and Repair. Cell Rep. 2020 12 29; 33(13):108553. PMID: 33378665.

    Read at: PubMed
  • Published on 12/22/2020

    Yeung AK, Villacorta-Martin C, Hon S, Rock JR, Murphy GJ. Lung megakaryocytes display distinct transcriptional and phenotypic properties. Blood Adv. 2020 12 22; 4(24):6204-6217. PMID: 33351116.

    Read at: PubMed
  • Published on 4/2/2020

    Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020 04 02; 26(4):482-502. PMID: 32243808.

    Read at: PubMed
  • Published on 10/1/2019

    Engler AE, Mostoslavsky G, Miller L, Rock JR. Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque. Methods Protoc. 2019 Oct 01; 2(4). PMID: 31581513.

    Read at: PubMed
  • Published on 5/2/2019

    Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya DK, Rock JR, Harfe BD, Menini A, Pifferi S. TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium. J Gen Physiol. 2019 07 01; 151(7):954-966. PMID: 31048412.

    Read at: PubMed
  • Published on 3/28/2019

    Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM. Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility. J Physiol. 2019 05; 597(9):2337-2360. PMID: 30843201.

    Read at: PubMed
  • Published on 3/12/2019

    Zawieja SD, Castorena JA, Gui P, Li M, Bulley SA, Jaggar JH, Rock JR, Davis MJ. Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels. J Gen Physiol. 2019 04 01; 151(4):532-554. PMID: 30862712.

    Read at: PubMed

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