James A. Hamilton, PhD

James Hamilton
700 Albany St Ctr for Adv Biomed Res


Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.

Other Positions

  • Professor, Physiology & Biophysics, Boston University School of Medicine
  • Professor, Radiology, Boston University School of Medicine
  • Research Associate Professor, General Internal Medicine, Medicine, Boston University School of Medicine
  • Research Associate Professor, Biochemistry, Boston University School of Medicine
  • Member, Whitaker Cardiovascular Institute, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences


  • Indiana University Bloomington, PhD
  • Juniata College, BS

Classes Taught

  • GMSNU804
  • GMSOH730


  • Published on 7/8/2020

    Taylor EN, Huang N, Wisco J, Wang Y, Morgan KG, Hamilton JA. The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds. J Transl Med. 2020 Jul 08; 18(1):277. PMID: 32641073.

    Read at: PubMed
  • Published on 2/26/2020

    Jay AG, Simard JR, Huang N, Hamilton JA. SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect FA translocation. J Lipid Res. 2020 May; 61(5):790-807. PMID: 32102800.

    Read at: PubMed
  • Published on 1/15/2019

    Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, Stayrook KR, Allen MR, Wallace JM, Bidwell JP. Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E749-E772. PMID: 30645175.

    Read at: PubMed
  • Published on 12/15/2018

    Zeng B, Liao J, Zhang H, Fu S, Chen W, Pan G, Li Q, Chen W, Ferrone S, Wu B, Sun S, Hu J, Ahn MH, Lin Z, Yu D, Ou Z, Wang X, Mo F, Huang N, Hamilton JA, Li J, Fan S. Novel ANO5 mutation c.1067G>T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia. Head Neck. 2019 01; 41(1):230-238. PMID: 30554457.

    Read at: PubMed
  • Published on 11/22/2018

    Mitra R, Qiao J, Madhavan S, O'Neil GL, Ritchie B, Kulkarni P, Sridhar S, van de Ven AL, Kemmerling EMC, Ferris C, Hamilton JA, Ebong EE. The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation. Transl Med Commun. 2018; 3. PMID: 30957020.

    Read at: PubMed
  • Published on 11/22/2018

    Ronodeep Mitra, Ju Qiao, Sudharsan Madhavan, Gerard L. O’Neil, Bailey Ritchie, Praveen Kulkarni, Srinivas Sridhar, Anne L. van de Ven, Erica M. Cherry Kemmerling, Craig Ferris, James A. Hamilton and Eno E. Ebong. The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation. Translational Medicine Communications. 2018; 10(3).

  • Published on 8/1/2018

    Taylor E, Huang N, Bodde J, Ellison A, Killiany R, Bachschmid MM, Hamilton J. MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits. J Transl Med. 2018 08 01; 16(1):215. PMID: 30068362.

    Read at: PubMed
  • Published on 4/1/2018

    EA Kolar, E Gajrawala, J Deeney, J Hamilton. FASEB JOURNAL. Understanding the role of pancreatic beta-cell CD36 in the development of Type 2 Diabetes . 2018; 32(1).

  • Published on 3/22/2018

    TE Van Dyke, H Hasturk, A Kantarci, JA Hamilton. Methods for Stabilizing Atherosclerotic Plaques Using Lipoxins, Resolvins, and Analogs Thereof. 2018.

  • Published on 2/1/2018

    Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 02 01; 141(2):422-458. PMID: 29360998.

    Read at: PubMed

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