Irina N. Gorshkova, PhD

Senior Research Scientist, Physiology & Biophysics

Irina Gorshkova
(617) 638-4003
700 Albany St Ctr for Adv Biomed Res

Education

  • National Cardiology Research Center, PhD
  • Moscow State University, MS

Publications

  • Published on 12/5/2017

    Gorshkova IN, Mei X, Atkinson D. Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity. J Lipid Res. 2017 Dec 05. PMID: 29208698.

    Read at: PubMed
  • Published on 2/13/2017

    Gorshkova IN, Atkinson D. Increased Binding of Apolipoproteins A-I and E4 to Triglyceride-Rich Lipoproteins is linked to Induction of Hypertriglyceridemia. JSM Atheroscler. 2017; 2(2). PMID: 28597004.

    Read at: PubMed
  • Published on 6/11/2014

    Gorshkova IN, Mei X, Atkinson D. Binding of human apoA-I[K107del] variant to TG-rich particles: implications for mechanisms underlying hypertriglyceridemia. J Lipid Res. 2014 Sep; 55(9):1876-85. PMID: 24919401.

    Read at: PubMed
  • Published on 4/19/2011

    Kateifides AK, Gorshkova IN, Duka A, Chroni A, Kardassis D, Zannis VI. Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL. J Lipid Res. 2011 Jul; 52(7):1363-72. PMID: 21504968.

    Read at: PubMed
  • Published on 2/20/2011

    Gorshkova IN, Atkinson D. Enhanced binding of apolipoprotein A-I variants associated with hypertriglyceridemia to triglyceride-rich particles. Biochemistry. 2011 Mar 29; 50(12):2040-7. PMID: 21288012.

    Read at: PubMed
  • Published on 11/25/2008

    Gorshkova IN, Kypreos KE, Gantz DL, Zannis VI, Atkinson D. Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia. Biochemistry. 2008 Nov 25; 47(47):12644-54. PMID: 18959431.

    Read at: PubMed
  • Published on 1/31/2006

    Gorshkova IN, Liu T, Kan HY, Chroni A, Zannis VI, Atkinson D. Structure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutation. Biochemistry. 2006 Jan 31; 45(4):1242-54. PMID: 16430220.

    Read at: PubMed
  • Published on 8/17/2004

    Chroni A, Kan HY, Kypreos KE, Gorshkova IN, Shkodrani A, Zannis VI. Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice. Biochemistry. 2004 Aug 17; 43(32):10442-57. PMID: 15301543.

    Read at: PubMed
  • Published on 12/17/2002

    Chroni A, Liu T, Gorshkova I, Kan HY, Uehara Y, Von Eckardstein A, Zannis VI. The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo. J Biol Chem. 2003 Feb 28; 278(9):6719-30. PMID: 12488454.

    Read at: PubMed
  • Published on 8/20/2002

    Gorshkova IN, Liu T, Zannis VI, Atkinson D. Lipid-free structure and stability of apolipoprotein A-I: probing the central region by mutation. Biochemistry. 2002 Aug 20; 41(33):10529-39. PMID: 12173940.

    Read at: PubMed

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