Asish K. Saha, PhD

Research Associate Professor, Medicine

(617) 638-7169
650 Albany St Evans Biomed Research Ctr

Biography

Expertise in invitro muscle incubation. Determine proteon expression by SDS-gel electrophoresis. Gene analysis by RT-PCR. Cell culture. Expertise in spectrophotometric and radioactive assay methods.

Other Positions

  • Boston Medical Center

Education

  • University of Calcutta, PhD
  • University of Calcutta, MS
  • University of Calcutta, BS

Publications

  • Published on 5/16/2017

    Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57. PMID: 28526426.

    Read at: PubMed
  • Published on 3/14/2016

    Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R, Harwood HJ. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1796-805. PMID: 26976583.

    Read at: PubMed
  • Published on 1/21/2016

    Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75. PMID: 26797128.

    Read at: PubMed
  • Published on 8/31/2015

    Doménech E, Maestre C, Esteban-Martínez L, Partida D, Pascual R, Fernández-Miranda G, Seco E, Campos-Olivas R, Pérez M, Megias D, Allen K, López M, Saha AK, Velasco G, Rial E, Méndez R, Boya P, Salazar-Roa M, Malumbres M. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat Cell Biol. 2015 Oct; 17(10):1304-16. PMID: 26322680.

    Read at: PubMed
  • Published on 5/22/2015

    Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 2015 Sep; 64(9):3155-9. PMID: 26001396.

    Read at: PubMed
  • Published on 5/21/2015

    Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388. PMID: 25996822.

    Read at: PubMed
  • Published on 12/23/2014

    Martínez de Morentin PB, Lage R, González-García I, Ruíz-Pino F, Martins L, Fernández-Mallo D, Gallego R, Fernø J, Señarís R, Saha AK, Tovar S, Diéguez C, Nogueiras R, Tena-Sempere M, López M. Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. Endocrinology. 2015 Mar; 156(3):947-60. PMID: 25535827.

    Read at: PubMed
  • Published on 8/27/2014

    Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/4?¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys. 2014 Nov 15; 562:62-9. PMID: 25172224.

    Read at: PubMed
  • Published on 6/24/2014

    Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53. PMID: 25018645.

    Read at: PubMed
  • Published on 5/22/2014

    Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab. 2014 Jul 1; 20(1):41-53. PMID: 24856932.

    Read at: PubMed

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