As a neonatologist, I am focused on understanding how maternal and/or environmental factors can affect placental function and development to cause fetal and neonatal diseases such as fetal growth restriction (FGR) and neonatal abstinence syndrome. My work to date has focused on understanding the underlying molecular mechanisms for fetal growth restriction (FGR), with an emphasis on smoking-related fetal growth restriction. I am studying the effects of altered placental Wnt signaling and carbon monoxide exposure in the pathogenesis of fetal growth restriction, using cell-based assays, mouse models of pregnancy and clinical studies. The major goals of my work are to discern how environmental exposures and maternal disease can alter fundamental signaling pathways such as Wnt signaling in the placenta, and to identify and validate novel placental biomarkers of fetal/neonatal diseases that may also drive disease process.
- Active Staff Privileges, Pediatrics, Boston Medical Center
- Duke University School of Medicine, MD
- Duke University, BS
- Published on 2/21/2017
Wang AM, Karumanchi SA. Offspring Cardiovascular Disease in Preeclampsia: Nature Versus Nurture? Hypertension. 2017 Apr; 69(4):589-590. PMID: 28223476.
- Published on 2/10/2017
Spiel M, Salahuddin S, Pernicone E, Zsengeller Z, Wang A, Modest AM, Karumanchi SA, Hecht JL. Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes. Placenta. 2017 Apr; 52:10-16. PMID: 28454690.
- Published on 6/6/2016
Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 Jul 01; 126(7):2561-74. PMID: 27270170.
- Published on 9/28/2015
Wang A, Zsengellér ZK, Hecht JL, Buccafusca R, Burke SD, Rajakumar A, Weingart E, Yu PB, Salahuddin S, Karumanchi SA. Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth. J Clin Invest. 2015 Nov 2; 125(11):4021-5. PMID: 26413870.
- Published on 1/12/2012
Wang A, Karumanchi SA. Relaxin' with endothelial progenitor cells. Blood. 2012 Jan 12; 119(2):326-7. PMID: 22247520.
- Published on 12/13/2011
Wang A, Holston AM, Yu KF, Zhang J, Toporsian M, Karumanchi SA, Levine RJ. Circulating anti-angiogenic factors during hypertensive pregnancy and increased risk of respiratory distress syndrome in preterm neonates. J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1447-52. PMID: 22097923.
- Published on 3/3/2011
Powe CE, Ecker J, Rana S, Wang A, Ankers E, Ye J, Levine RJ, Karumanchi SA, Thadhani R. Preeclampsia and the risk of large-for-gestational-age infants. Am J Obstet Gynecol. 2011 May; 204(5):425.e1-6. PMID: 21371687.
- Published on 6/1/2009
Wang A, Rana S, Karumanchi SA. Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda). 2009 Jun; 24:147-58. PMID: 19509125.
- Published on 4/1/2009
Rauh-Hain JA, Rana S, Tamez H, Wang A, Cohen B, Cohen A, Brown F, Ecker JL, Karumanchi SA, Thadhani R. Risk for developing gestational diabetes in women with twin pregnancies. J Matern Fetal Neonatal Med. 2009 Apr; 22(4):293-9. PMID: 19340713.
- Published on 5/26/2005
Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8281-6. PMID: 15919816.