Research Projects for Medical Students at BUSM
The Enrichment Office at BUSM matches BUMC faculty with research needs with BU medical students who are interested in participating in short- or long-term research. The projects listed below were provided by BUMC faculty members for this purpose. Interested medical students are encouraged to directly contact the mentors listed for more information.
Guidelines for Students:
- Medical students are encouraged to read project descriptions carefully and consider their availability and time commitment for projects they choose to pursue.
- Once an agreement is reached by the student and mentor to engage in a project, the student should contact Ana Gregory, Enrichment Office.
Faculty Members:
- If you are a faculty member who would like to add a project to the list, you may submit it here: Research Project Submission Form. Faculty members with projects on the list that need to be updated or deleted may contact Ana Gregory.
Research Projects (listed by department)
Medicine
Biomedical computer vision
- Description of Research Project: Our lab is interested in the development of advanced machine learning algorithms to process a wide variety of medical imaging datasets to address interesting questions in clinical medicine. Our current areas of interest are Alzheimer’s disease, osteoarthritis, chronic kidney disease and cancer. See for example: http://www.bu.edu/articles/2020/deep-learning-algorithm-outperforms-experts-in-making-alzheimers-diagnosis/. Our trainees have been part of peer-reviewed publications in highly respected journals and won awards including the MSSRP funding to support their research and national recognition such as Toffler Scholars. See here: http://www.bumc.bu.edu/busm/2021/02/10/2021-toffler-scholars-in-neuroscience-announced/
- Department: Medicine
- Contact Person: Vijaya Kolachalama (vkola@bu.edu)
- Specialty(ies) of Research Project: Data Science
- What type of project is this? Other
- Website: http://sites.bu.edu/vkola/
- Last updated: 10/12/2021
Kidney Functional Reserve
- Description of Research Project: We usually estimate kidney function by measuring serum creatinine concentration. Directly measuring kidney function requires techniques like inulin clearance or para aminohippurate (PAH) clearance to measure glomerular filtration rate (GFR) and renal plasma flow (GFR). We have an ongoing study to measure GFR and RPF using urinary clearance of iohexol and PAH. We are doing this to test the concept for kidney functional reserve: GFR is not static, but increases in response to various physiological stimuli. GFR increases in dogs by 50% after a high protein meal. GFR decreases substantially in hibernating bears. How much does GFR change in humans after physiological stimuli? What are the physiological determinants of this? Can we develop a simplified test using plasma or urinary metabolomics to measure kidney functional reserve with just a single or paired lab tests? These are the questions we seek to answer in this project funded by NIH (https://grantome.com/grant/NIH/R21-DK119751-01)
- Department: Medicine
- Contact Person: Sushrut Waikar (swaikar@bu.edu)
- Specialty(ies) of Research Project: Nephrology
- What type of project is this? Clinical Science
- Website: https://profiles.bu.edu/Sushrut.Waikar
- Last updated: 10/12/2021
Rare Neurodevelopmental Disease
- Description of Research Project: Interested students can become involved in quantitative methods research with a focus on a rare neurodevelopmental disease
- Department: Medicine
- Contact Person: Isabel Dominguez (isdoming@bu.edu)
- Specialty(ies) of Research Project: Genetics; Neural development, Skeletal Development, Animal Behavior
- What type of project is this? Biomedical Science
- Last updated: 10/12/2021
Education
- Description of Research Project: Interested students can become involved in a mixed-methods research with a focus on under-representation in Biomedicine
- Department: Medicine
- Contact Person: Isabel Dominguez (isdoming@bu.edu)
- Specialty(ies) of Research Project: Underrepresented groups in Biomedicine
- What type of project is this? Medical Education
- Last updated: 10/12/2021
Embryonic Development
- Description of Research Project: Interested students can become involved in quantitative methods research with a focus on understanding gene expression patterns and the role of genes in embryonic development
- Department: Medicine
- Contact Person: Isabel Dominguez (isdoming@bu.edu)
- Specialty(ies) of Research Project: Embryonic development, cell biology, molecular biology, biochemistry
- What type of project is this? Biomedical Science
- Last updated: 10/12/2021
Cancer Mutations
- Description of Research Project: Interested students can become involved in quantitative methods research with a focus on cancer mutations in 4 different genes
- Department: Medicine
- Contact Person: Isabel Dominguez (isdoming@bu.edu)
- Specialty(ies) of Research Project: cancer, genetics, functional effect of mutations
- What type of project is this? Biomedical Science
- Last updated: 10/12/2021
Neurology
Computational and network models of nightmares
- Description of Research Project: Seeks to develop neural network architectures that can account for nightmare phenomenology and allow for exploration of cognitive neuroscience mechanisms of nightmare phenomenology.
- Department: Neurology
- Contact Person: Patrick McNamara (mcnamar@bu.edu)
- Specialty(ies) of Research Project: Sleep medicine
- What type of project is this? Clinical Science
- Last updated: 10/12/2021
Clinical and diagnostic predictors of functional outcome in patients with Traumatic Brain Injury at Boston Medical Center
- Description of Research Project: The TBI study is a collaborative study between the departments of Neurology, Neurosurgery, Trauma surgery, Radiology and Anesthesia. The study aims to establish a TBI database at Boston medical center, which is the largest level 1 trauma center in New England. The other aims of the project are studying the clinical and diagnostic predictors of outcome in patients with TBI.
- Department: Neurology
- Contact Person: Kushak Suchdev (ksuchdev@bu.edu)
- Specialty(ies) of Research Project: Neurology, Neurosurgery, Trauma Surgery, Radiology and Anesthesia
- What type of project is this? Clinical Science, Public Health
- Last updated: 10/12/2021
Ophthalmology
Immunobiology of the retina
- Description of Research Project: Within the healthy eye, there are mechanisms to control and manipulate immunity necessary to preserve vision. Several specific neuropeptides constitutively present within the eye regulate different immune cells and different immune cell functions. Collectively they suppress inflammation, promote immune cell-mediated anti-inflammatory activity and immune tolerance. Understanding how these neuropeptides alter immunity and how they work together to suppress inflammation has a profound impact on finding ways to reestablish health in the eyes following infection, graft rejection, autoimmune disease, and trauma. Our experimental approach uses molecular biology, biochemistry, histology, immunohistochemistry, flow cytometry, gene delivery, cultured immune cells, and immune model techniques. Each student has a separate research opportunity linked to the general study of vision science and immunobiology.
- Department: Ophthalmology
- Contact Person: Andrew Taylor (awtaylor@bu.edu)
- Specialty(ies) of Research Project: ophthalmology, pharmacology, immunology
- What type of project is this? Basic Science
- Website: https://www.bumc.bu.edu/ophthalmology/research-programs/andrew-w-taylor-phd/
- Last updated: 10/12/2021
Retina Research Projects
- Description of Research Project: I enjoy working with medical students, residents and fellows who are interested in clinical and translational research within the fields of medical and surgical retina, electronic medical records and ophthalmic technologies. My goal is to have each trainee take ownership of an individual project and bring it to completion with publication. Please feel free to contact me to discuss potential project ideas.
- Department: Ophthalmology
- Contact Person: Xuejing Chen (chen@bmc.org)
- Specialty(ies) of Research Project: Ophthalmology
- What type of project is this? Clinical Science, Quality Improvement
- Last updated: 10/12/2021
Otolaryngology
Many Otolaryngology Projects
- Description of Research Project: The Department of Otolaryngology always has research projects available. Dr. Levi is willing to meet with any student interested in ENT research and help direct them to potential mentors (set up by Janine Lipsky). Dr. Levi also has some of her own research on topics including pediatric otolaryngology conditions (sleep apnea, hearing, etc), women in surgery/otolaryngology, and access to healthcare and health disparities.
- Department: Otolaryngology
- Contact Person: Jess Levi or Janine Lipsky (lipsky@bmc.org)
- Specialty(ies) of Research Project: ENT
- What type of project is this? Clinical Science, Public Health, , Medical Education, Quality Improvement
- Last updated: 10/12/2021
Pediatrics
CK-Ready Study
- Description of Research Project: We are seeking a Research Assistant to help with the C-K-READY Study. The C-K-READY team is within the Department of Pediatrics at Boston Medical Center and Vital Village Networks is implementing a multi-site, cluster randomized trial aimed at evaluating the impact of the group well-child care model of primary care vs. routine care on new babies and mothers. Specifically, Project C-K-READY will explore the impact of care models on child development and school readiness at 12 and 24 months. We will be partnering with several pediatric practices across the United States to conduct thisr esearch study. The principal responsibility of this individual will be to administer a standardized phone questionnaire to participants and engage in recruitment calls. Additional responsibilities include assisting student Research Assistants with recruitment calls, administrative duties related to project implementation, and database entry and management. Requirements:1)Experience in interviewing and/or administering research surveys and protocols.2)Ability to communicate effectively (via telephone).3)Flexibility to work some evenings and weekends is required.Specific duties and requirements are listed below:1)Enrollment of parents into research study.2)Administer standardized research protocol to participantsusing REDCap, our electronic data capture system.3)Maintain electronic and paper files of participants and file systems.4)Participate as research team member with Principal Investigator(s) and study team.Attend team meetings.5)Comply with BUMC Research/HIPAA standards.Time commitment will range from 10-16 hours per week for part-time and 40 hours per week for full-time. Hours will vary. Please send cover letter and resume/CV to Dr. Renee Boynton-Jarrett; renee.boyntonjarrett@bmc.org
- Department: Pediatrics
- Contact Person: Renee Boynton-Jarrett (boyntonjarrett@bmc.org)
- Specialty(ies) of Research Project: Pediatrics, Public Health, Social Epidemiology
- What type of project is this? Clinical Science, Public Health, , Quality Improvement
- Website: https://www.vitalvillage.org/projects/c-k-ready
- Last updated: 10/12/2021
Psychiatry
Predicting Future Suicidal Behavior Using Implicit Association Testing Administered in the Psychiatric Emergency Department of a Safety Net Hospital
- Description of Research Project: For those at risk of harming themselves or taking their own lives, there are limited tools available to assess their level of risk and whether they need to be psychiatrically hospitalized. One reason for this is that risk assessment tools rely on self-report, and often people with suicidal ideas and plans may deny having these thoughts if they fear stigma or fear that they will be prevented from attempting suicide. Implicit Association Testing (IAT) is a computer-based test that has been studied to show the associations people hold, and the strength of these associations can relate to past or future behavior. Specifically, it has been shown that a form of the IAT-the Suicide Implicit Association Test (S-IAT) can measure people’s associations between the “self” and concepts relating to death/dying/suicide and that results of the S-IAT can be related to suicidal behavior. Another form of the IAT-the Self-Injury Implicit Association test (SI-IAT) can measure people’s associations between self and non-suicidal self-injury (NSSI). We plan to administer the S-IAT and SI-IAT to patients who present to the BMC ED who receive a consultation from psychiatric emergency services and then subsequently follow-up with these patients three months later to note their outcomes after leaving the BMC ED. The S-IAT and SI-IAT scores, survey results, and follow-up results can be analyzed to determine the feasibility of implementing the S-IAT and SI-IAT in the emergency department and see if these IATs can predict future suicidality and suicidal ideation. If so, it would provide further evidence of IAT’s usefulness as a tool for predicting suicide risk and could potentially help clinicians keep at-risk patients safe. In addition, testing the S-IAT and SI-IAT in the diverse population of the BMC ED, with additional questionnaires assessing social determinants of health (SDOH) and discrimination, can show the strength of the correlation between SDOH and suicidal behavior. The student would primarily be responsible for in-person recruitment of patients, consenting patients, and administering the S-IAT, SI-IAT, and questionnaires involved in the baseline study visit. They would also be responsible for reaching out to patients over email and/or phone to administer follow-up surveys. Students may also help with data analysis and writing reports of this project. The emergency department is a 24-hour service, so student’s schedules can be flexible. The student must commit to a minimum of 10-15 hours/week for this project, but most, if not all, of that time would be spent working in person in BMC’s Emergency Department. The student must be comfortable working in an emergency department, talking to people on the phone, and working with patients with psychiatric illnesses. They must also have strong organizational skills, be self-motivated, and capable of working independently. Good communication and interpersonal skills are also required to work with patients. An interest in novel interventions in psychiatry would be preferred. This study will also include Spanish-speaking participants, so fluent Spanish speakers would also be preferred.
- Department: Psychiatry
- Contact Person: Alison Duncan (duncan@bmc.org)
- Specialty(ies) of Research Project: Emergency Psychiatry
- What type of project is this? Clinical Science, Public Health, , QI
- Last updated: 10/12/2021
Communication Challenges for Parents of Adolescents with ADHD
- Description of Research Project: Parents of adolescents with ADHD endure increased parenting stress and lower quality of life in the context of raising adolescent who are at elevated risk for engaging in health risk behaviors. Most parenting skills classes are targeted towards parents of young children but adolescents present different challenges for parents. This study’s goal is to conduct interviews of parents and their adolescents with ADHD and analyze these interviews to identify challenges and techniques that could be addressed in a parenting skills class.
- Students would help in analysis of these interviews and parent and adolescent questionnaire responses. Interview analysis would be done through thematic analysis and coding in NVivo. Questionnaire analysis would be conducted using a statistical software. Students would also likely help write a report or paper on the results of these analyses. A minimum commitment of 5 hours/week is required, but dates and timing within the week is flexible. This project is entirely remote.
- Students should have strong organizational skills, be self-motivated, and be capable of working independently. Previous experience in qualitative/quantitative analyses would be strongly preferred.
- Department: Psychiatry
- Contact Person: Alison Duncan (duncan@bmc.org)
- Specialty(ies) of Research Project: Adolescent Psychiatry
- What type of project is this? Clinical Science
- Last updated: 10/12/2021
Assessing the effects of the COVID-19 infection and pandemic restrictions on patients who received psychiatric emergency services at BMC
- Description of Research Project: COVID-19 has spread around the world in the past year and significantly changed people’s lifestyles and socialization. This study focuses on the high needs population of patients who received psychiatric emergency services (PES) since the COVID-19 pandemic and examines the effect of the pandemic on patients’ mental health. This study also aims to compare the mental health and social determinants of health of PES patients who were infected with COVID-19 with PES patients who were not. We hope to make these correlations through a detailed phone/email survey of a randomized sample of PES patients since March 2020.
- Students would be responsible for recruiting patients over the phone, consenting them, and administering surveys over the phone or email. They may also help with data analysis and writing a report on the results of this study. A minimum commitment of 5 hours/week is required, but dates and timing within the week is flexible. This project is entirely remote.
- Students must be comfortable talking to people on the phone and working with patients with psychiatric illnesses. They must also have strong organizational skills, be self-motivated, have good interpersonal skills, and be capable of working independently. This study will also include Spanish-speaking participants, so fluent Spanish speakers would be preferred. Previous clinical research or clinical experience would also be preferred.
- Department: Psychiatry
- Contact Person: Alison Duncan (duncan@bmc.org)
- Specialty(ies) of Research Project: Emergency Psychiatry
- What type of project is this? Clinical Science, Public Health
- Last updated: 10/12/2021
Radiology
Brain Anatomy of Adolescents Born Extremely Preterm: Gray Matter and Cognition
- Description of Research Project: Study in the context of the ELGAN-ECHO project (https://elgan.fpg.unc.edu/). A large data-bank of 470 brain MRIs is available for processing with quantitative techniques. Aim of this sub-study is to segment and quantify the deep gray matter structures and correlate derived measures with IQ.
- Department: Radiology
- Contact Person: Hernan Jara (hjara@bu.edu)
- Specialty(ies) of Research Project: Radiology
- What type of project is this? Basic Science
- Website: https://elgan.fpg.unc.edu/
- Last updated: 10/12/2021