{"id":2803,"date":"2022-08-22T14:41:53","date_gmt":"2022-08-22T18:41:53","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-wci\/?p=2803"},"modified":"2022-08-29T10:49:51","modified_gmt":"2022-08-29T14:49:51","slug":"dr-jiang-and-his-group-reported-recently-that-neutrophil-elastase-ne-regulates-vascular-endothelial-cell-permeability","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/busm-wci\/2022\/08\/22\/dr-jiang-and-his-group-reported-recently-that-neutrophil-elastase-ne-regulates-vascular-endothelial-cell-permeability\/","title":{"rendered":"Dr. Jiang and his group reported recently that neutrophil elastase (NE) regulates vascular endothelial cell permeability."},"content":{"rendered":"<p><span data-contrast=\"none\" xml:lang=\"EN-US\" lang=\"EN-US\" class=\"TextRun SCXW78132034 BCX0\"><span class=\"NormalTextRun SCXW78132034 BCX0\">Dr. Jiang and his group reported <\/span><span class=\"NormalTextRun SCXW78132034 BCX0\">recently <\/span><span class=\"NormalTextRun SCXW78132034 BCX0\">that neutrophil elastase (NE), a protease secreted from neutrophils, regulates vascular endothelial cell permeability. NE cleaves and activates protease-activated receptor-2, leading to actomyosin cytoskeletal activation, cell junction molecule VE-cadherin degradation, and increased endothelial permeability. Inhibition and deletion of NE in mice protect obesogenic diet-induced vascular leakage and immune cells in tissues such as white adipose tissue and the heart. This work <\/span><span class=\"NormalTextRun SCXW78132034 BCX0\">was<\/span><span class=\"NormalTextRun SCXW78132034 BCX0\"> published in\u202f<\/span><\/span><span data-contrast=\"none\" xml:lang=\"EN-US\" lang=\"EN-US\" class=\"TextRun SCXW78132034 BCX0\"><span class=\"NormalTextRun SCXW78132034 BCX0\">Cells<\/span><\/span><span data-contrast=\"none\" xml:lang=\"EN-US\" lang=\"EN-US\" class=\"TextRun SCXW78132034 BCX0\"><span class=\"NormalTextRun SCXW78132034 BCX0\">\u202f(<\/span><\/span><a href=\"https:\/\/www.mdpi.com\/2073-4409\/11\/15\/2288\/htm\"><span data-contrast=\"none\" xml:lang=\"EN-US\" lang=\"EN-US\" class=\"TextRun Highlight SCXW78132034 BCX0\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW78132034 BCX0\">Ushakumari<\/span><span class=\"NormalTextRun SCXW78132034 BCX0\"> et al <\/span><\/span><\/a><span data-contrast=\"none\" xml:lang=\"EN-US\" lang=\"EN-US\" class=\"TextRun SCXW78132034 BCX0\"><span class=\"NormalTextRun SCXW78132034 BCX0\">2022, https:\/\/www.mdpi.com\/2073-4409\/11\/15\/2288).\u202f<\/span><\/span><span class=\"EOP SCXW78132034 BCX0\" data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559737&quot;:45}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Jiang and his group reported recently that neutrophil elastase (NE), a protease secreted from neutrophils, regulates vascular endothelial cell permeability. NE cleaves and activates protease-activated receptor-2, leading to actomyosin cytoskeletal activation, cell junction molecule VE-cadherin degradation, and increased endothelial permeability. Inhibition and deletion of NE in mice protect obesogenic diet-induced vascular leakage and immune [&hellip;]<\/p>\n","protected":false},"author":20986,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[914,921],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/posts\/2803"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/users\/20986"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/comments?post=2803"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/posts\/2803\/revisions"}],"predecessor-version":[{"id":2807,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/posts\/2803\/revisions\/2807"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/media?parent=2803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/categories?post=2803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/tags?post=2803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}