{"id":5,"date":"2003-08-09T10:55:48","date_gmt":"2003-08-09T14:55:48","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/busm-wci\/accomplishments\/"},"modified":"2017-10-03T14:40:38","modified_gmt":"2017-10-03T18:40:38","slug":"accomplishments","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/busm-wci\/accomplishments\/","title":{"rendered":"Accomplishments"},"content":{"rendered":"

Highlights of Accomplishments at Boston University Medical Center<\/h3>\n

1940<\/h4>\n
Reginald H. Smithwick, M.D., pioneers the surgical treatment of hypertension<\/div>\n

1949<\/h4>\n
Robert W. Wilkins, M.D., and associates are first in the Western world to use reserpine-type drugs in the treatment of high blood pressure<\/div>\n

1954<\/h4>\n
Step-care approach to the treatment of hypertension is formulated; Robert W. Wilkins, M.D., named President, American Heart Association<\/div>\n

1958<\/h4>\n
BUMC research team first to uses the diuretic chlorothiazide for the treatment of patients with hypertension; Lasker Award to Robert W. Wilkins, M.D., for his work on anti-hypertensive drug therapy<\/div>\n

1962<\/h4>\n
First to use the aldosterone antagonist spironolactone in the treatment of hypertension<\/div>\n

1968<\/h4>\n
Pioneering work in development of extra-anatomic bypass procedures in peripheral vascular surgery<\/div>\n

1971<\/h4>\n
Discovery of the hormone 18-hydroxy-deoxycorticosterone in genetic animal models of hypertension and humans<\/div>\n

1977<\/h4>\n
First use of angiotensin converting enzyme inhibitor captopril in hypertension; first use of angiotensin converting enzyme inhibitors in heart failure<\/div>\n

1978<\/h4>\n
Pioneering work to establish the use of a Left Ventricular Assist Device in Open Heart Surgery<\/div>\n

1979<\/h4>\n
Continuing leadership in the long-standing Boston University\/Framingham Heart Study, which identified the key risk factors associated with cardiovascular disease<\/div>\n

1983<\/h4>\n
The first delineation of the vascular response to balloon angioplasty<\/div>\n

1984<\/h4>\n
Thomas J. Ryan, M.D., named President, American Heart Association<\/div>\n

1986<\/h4>\n
The first use of thermal laser angioplasty in humans<\/div>\n

1994<\/h4>\n
First demonstration of deficiency of nitric oxide as a cause for thrombosis<\/div>\n

1996<\/h4>\n
Elucidation of role of nitric oxide in salt sensitive hypertension<\/div>\n

1998<\/h4>\n
Use of heparin-bonded cardiopulmonary bypass circuits to limit bleeding risk and ransfusion requirements for patients undergoing heart surgery<\/div>\n

2000-2002<\/h4>\n
Identification of genetic polymorphisms that contribute to hypertension, thrombosis, and heart failure<\/div>\n

2001<\/h4>\n
Role of glucose-6-phosphate dehydrogenase as a critical determinant of vascular oxidant stress<\/div>\n

2002<\/h4>\n
Identification of novel molecular determinants of angiogenesis<\/div>\n

2002<\/h4>\n
Identification of a molecular mechanism of adriamycin cardiotoxicity<\/div>\n

2003<\/h4>\n
Use of glucose-insulin-potassium solution to improve outcome in diabetic patients undergoing coronary artery bypass surgery<\/div>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Highlights of Accomplishments at Boston University Medical Center 1940 Reginald H. Smithwick, M.D., pioneers the surgical treatment of hypertension 1949 Robert W. Wilkins, M.D., and associates are first in the Western world to use reserpine-type drugs in the treatment of high blood pressure 1954 Step-care approach to the treatment of hypertension is formulated; Robert W. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/pages\/5"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":2,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":865,"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/pages\/5\/revisions\/865"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/busm-wci\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}