Wendy Wei Qiao Qiu, M.D., Ph.D.
Professor of Psychiatry and PharmacologyDepartment of Pharmacology & Experimental Therapeutics
M.D.: Beijing Medical College
|Wendy Qiu is a Professor in the Psychiatry Department, Pharmacology & Experimental Therapeutics Department, Alzheimer’s disease Center (ADC) at Boston University School of Medicine. She is also a faculty member in the Neuroscience Program at Boston University.
Dr. Qiu is both a physician and a scientist. She is a Board Certified Psychiatrist who was trained at Tufts Medical Center and at the Payne Whitney Clinic, New York Presbyterian Hospital, Cornell Medical Center. She currently spends 50% of her time caring for patients with dementia and other psychiatric illnesses, including late life depression, and seeing patients in the ADC for the clinical trials. Many of her patients seek care at BU because they are frustrated with their deteriorating cognitive function and their behavior or mood symptoms are causing tremendous burdens for their caregivers. Motivated by her desire to help patients with devastating diseases in geriatric psychiatry, especially dementia which frequently lacks diagnostic tools and effective therapies, Dr. Qiu devotes the other 50% of her time to researching the fundamental causational mechanisms of these diseases, and to translate her findings to seeking biomarkers for the diagnoses and treatment of psychiatric illnesses.
Study: ‘Persistent’ loneliness in middle age increases dementia risk. Health News
March 24, 2021 / 10:57 AM https://www.upi.com/Health_News/2021/03/24/dementia-loneliness-middle-age-study/3621616592581/
Persistent Loneliness at Midlife Linked to Late-life Dementia, Alzheimer’s Disease. Psychiatric News. Friday, March 26, 2021 https://alert.psychnews.org/2021/03/persistent-loneliness-at-midlife-linked.html
Dr. Wendy Qiu is corresponding author on BU Alzheimer’s Study Examining the Role of Inflammation in Alzheimer’s Disease. Boston Globe 2018 https://www.bumc.bu.edu/busm-pm/2018/10/29/dr-wendy-qiu-is-corresponding-author-on-bu-alzheimers-study-examining-the-role-of-inflammation-in-alzheimers-disease/
Diagnosis: Alzheimer’s disease. Looking for a better way to detect the disease early. The BRINK. The Pioneering Research from Boston University 2016. https://www.bu.edu/articles/2016/alzheimers-research-wendy-qiu/
A 16-Year-Old Takes on a Disease of the Elderly. Bostonia 2013. https://www.bu.edu/bostonia/2013/a-16-year-old-takes-on-a-disease-of-the-elderly/
|Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, Yan J, Yang JB, Tian JB, Zhu S, li Q, Rajab IM, Blusztajn JK, Wolozin B, Emili A, Zhang X, Stein T, Potempa LA and Qiu WQ: Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer’s disease pathology. bioRxiv doi: 1101/2021.05.30.446344; Aging Cell 2021 Nov;20(11):e13501. doi: 10.1111/acel.13501. Epub 2021 Oct 23. PMID: 34687487
Tao Q, Ang T, Akhter-khan S, Itchapurapu IS, Killiany R, Zhang X, Budson AE, Turk KW, Goldstein L, Mez J, Alosco ML and Qiu WQ: Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in homozygous Apolipoprotein E ɛ4 Neurology 2021 Jul 15;97(12):e1243-e1252. doi: 10.1212/WNL. 0000000000012512. PMID: 34266923
Na H, Tian H, Zhang Z, Li Q, Yang JB, Mcparland L, Gan Q and Qiu WQ: Oral amylin treatment reduces the pathological cascade of Alzheimer’s disease in a mouse model. American J. Alzheimer’s Disease 2021 Jan-Dec 2021;36:15333175211012867. doi: 10.1177/15333175211012867. PMID: 34137273
Akhter-Khan SC*, Tao Q*, Ang TFA, Itchapurapu IS, Alosco ML, Mez J, Piers RJ, Steffens DC, Au R and Qiu WQ. Associations of loneliness with risk of Alzheimer’s disease dementia in the Framingham Heart Study. Alzheimer’s & Dementia 2021 Mar 24. doi: 10.1002/alz.12327. PMID: 33760348
Sugarman MA, Zetterberg H, Blennow K, Tripodis Y, McKee AC, Stein TD, Martin B, Palmisana JN, Steinber EG, Simkin I, Budson AE, Killiany R, O’Connor MK, Au R, Qiu WQ, Goldstein LE, Kowall NW, Mez J, Stern RA, Alosco ML. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer’s disease. Neurobiology of Aging 2020. 94: 60-70. PMID: 32585491
Na H, Gan Q, Mcparland L, Yang JB, Yao H, Tian H, Zhang Z and Qiu WQ: Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer’s disease. Neuropharmacology 2020; 168:108017. PMID: 32113968
Zhu H, Tao Q, Ang T, Massaro J, Gan Q, Salim S, Zhu R, Kolachalama VB, Zhang X, Devine S, Auerbach SH, DeCarli C, Au A and Qiu WQ: Association of plasma amylin concentration with Alzheimer’s disease and brain structure in older adults. JAMA Network Open 2019; 2(8): e199826. PMC6707010
Gan Q, Yao H, Na H, Balance H, Tao Q, Leung L, Tian H, Zhu H, Wolozin B and Qiu WQ: Amylin’s effects against Aβ induced tauopathy and synapse loss in primary neurons. Journal of Alzheimer’s Disease 2019; 70(4): 1025-1040. PMC6833957
Tao Q, Ang T, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au A and Qiu WQ: Association of chronic low-grade inflammation with risk of Alzheimer disease in ApoE4 carriers. JAMA Network Open 2018; 70(4): 1025-1040, PMC6324596
Tao Q; Zhu H; Chen X; Stern RA; Kowall N; Au R; Blusztajn JK and Qiu WQ: Pramlintide: the effects of a single drug injection on blood phosphatidylcholine profile for Alzheimer’s disease. J. Alzheimer’s Disease 2018; 62(2):597-609 PMC5956916
Qiu WQ: Amylin and its G-protein-coupled receptor: a probable pathological process and drug target for Alzheimer’s disease, Neuroscience 2017 Jul 25;356:44-51 PMC5536977
Zhu H; Xue X; Wallack M; Na H; Hooker JM; Kowall N; Tao Q; Stein TD; Wolozin B; and Qiu WQ: Amylin receptor ligands reduce the pathological cascade of Alzheimer’s disease. Neuropharmacology 2017; 119:170-181 PMC6511375
Zhu, H; Stern, RA; Tao, Q; Bourlas, A; Essis, MD; Chivukula, M; Rosenzweig, J; Steenkamp, D; Xia, W; Mercier, GA; Tripodis, Y; Farlow, M; Kowall, N and Qiu, WQ: An amylin analog used as a challenge test for Alzheimer’s disease. Alzheimer’s Disease & Dementia: Translational Research & Clinical Interventions, 2017 Jan; 3:33-43 PMC5424531
Wang, E; Zhu, H; Wang, X; Gower, A; Wallack, M; Blusztajn, JK; Kowall, N and Qiu, WQ: Amylin treatment reduces neuroinflammation and ameliorates abnormal patterns of gene expression in the cerebral cortex of Alzheimer’s disease mouse model. Alzheimer’s disease, 2017; 56: 47-61 PMC5331853
Li H; Zhu H; Scott T; Wallack M; Mwamburi M; Abdul-Hay SO; Lessring M and Qiu WQ: Age and its association with low insulin and high amyloid-β peptides in blood. J. Alzheimer’s disease, 2015; 49(1): 129-37 PMC4835689
Zhu H; Wang X; Wallack M; Li H; Carreras I; Dedeoglu A; Hur J; Zheng H; Li H; Fine R; Sun X; Mwamburi M; Kowall N; Stern R; and Qiu WQ: Intraperitoneal Injection of the Pancreatic Peptide Amylin Potently Reduces Behavioral Impairment and Brain Amyloid Pathology In Murine Models of Alzheimer’s Disease. Molecular Psychiatry 2015 Feb; 20(2): 252-62 PMC4161670
Qiu WQ and Zhu H: Amylin and its analogs: a friend or foe for the treatment of Alzheimer’s disease? Front Aging Neurosci. 2014 Jul 29; 6:186 PMC4114192
Sun, X; Bhadelia RA; Liebson, E; Bergethon P; Folstein, M; Zhu, JJ; Mwamburi; Patz, S and Qiu, WQ: The Relationship between Plasma Amyloid-β Peptides and the Medial Temporal Lobe in the Homebound Elderly. Int J. Ger Psych 2011, Jun; 26:593-601 PMC5357567
Sun, X; Chiu, C.C; Liebson, E; Crivello, N. A; Wang, L; Folstein, M; Rosenberg, I; Mwamburi; Peter, I and Qiu, WQ: Depression and plasma Amyloid β peptides in the elderly with and without apolipoprotein E4 allele. Alzheimer’s Disease & Associated Disorder 2009, 23: 238-44 PMC2919337
Sun, X; Steffens, D.C; Folstein, M; Summergrad, P; Yee, J; Rosenberg, I; Au, R; Mwamburi, D.M and Qiu, WQ: Amyloid-associated depression: A prodromal depression of Alzheimer’s disease? Arch Gen Psych 2008, 65: 542-50 PMC3042807
Sun, X, Mwamburi, Bungay, K, Prasad, J, Yee, J, Lin, Y, Liu, TC, Summergrad, P, Folstein, M and Qiu, WQ: Depression, Antidepressants and Plasma Ab Peptides in those Elderly who do not have Cardiovascular Disease. Biological Psychiatry 2007; 62: 1413-7 PMID: 17544381
Qiu WQ, Price LL, Hibber P, Beull J, Collins L, Leins D, Mwamburi DM, Rosenberg, I, Smaldone BA, Scott TM, Siegel RD, Summergrad P, Sun X, Wagner C, Wang L, Yee J, Tucker K and Folstein M. Executive Dysfunction in Homebound Elderly with Diabetes J Ameri Geria Soci 2006; 54: 456-501 PMID: 16551319
Qiu WQ and Folstein MF. Insulin, insulin-degrading enzyme and amyloid-b peptide in Alzheimer’s disease: review and hypothesis. Neurobiology of Aging 2006; 27: 190-198 PMID: 16399206
Vekrellis K, Ye Z, Qiu WQ, Walsh D, Harley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amylid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci 2000; 20(5): 1657-65.
Qiu WQ, Walsh D, Ye Z, Vekrellis K, Zhang J, Podlisny M, Rosner M, Safavi A, Hersh LB, Selkoe DJ. Insulin degradation enzyme released from microglial cells degrades extracellular amyloid-beta peptide and stimulates its oligomerization. J Biol Chem. 1998; 273(49): 32730-32738.
Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates hippocampal neuronal adhesion and neurite outgrowth in an isoform-dependent manner. J Neurosci. 1995; 15: 2157-67.
Feinman R, Qiu WQ, Pearse RN, Nikolajczyk BS, Sen R, Sheffery M, Ravetch JV. PU.1 and an HLH family member contribute to the myeloid-specific transcribption of the Fc gamma RIIA promotor. EMBO J. 1994; 3852-60.
Qiu WQ, deBruin D, Brownstein BH, Pearse R, Ravetch JV. Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science 1990; 248: 723-735.