Vidhya Kumaresan, Ph.D.
|Research Assistant Professor, Pharmacology & Experimental Therapeutics
Laboratory: Laboratory of Molecular Neurobiology
Dr. Kumaresan’s overall research objective is to study neuronal activity-dependent plasticity and its relevance for brain disorders. The current focus of Dr. Kumaresan’s research is to understand the neurobiological bases of addiction to psychostimulants. Recidivism to drug abuse is a major hurdle in the successful treatment of addiction. Illicit drug use usurps neural circuits involved in survival enhancing behaviors. The goal is to elucidate the cellular and molecular underpinnings of drug-induced enduring neural plasticity in these circuits using a combination of behavioral, cellular and molecular approaches. In particular, Dr. Kumaresan employs a novel approach of using cell-permeable peptides that disrupt protein-protein interactions in vivo in order to study ongoing behavior. These approaches are expected to lead to successful treatment of relapse precipitated by drug re-exposure, drug-associated cues and stress. Knowledge gained from these studies will also be applicable to the treatment of other brain dysfunctions involving persistent memories such as PTSD.
|Ratner MH, Downing SS, Guo O, Odamah KE, Stewart TM, Kumaresan V, Robitsek RJ, Xia W, Farb DH. Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer’s disease. Heliyon, September 2021, 7(9): e07895. PMID: 34568591
Moazzam M, Yim T, Kumaresan V, Henderson DC, Farrer LA, Zhang H. Analysis of telomere length variation and Shelterin complex subunit gene expression changes in ethanol-exposed human embryonic stem cells. J Psychiatr Res. 2020 Nov 17:S0022-3956(20)31086-4.
Ratner M.H., Kumaresan V., Farb D.H.: (2019) Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders. Front. Endocrinol. 10:169. doi: 10.3389/fendo.2019.00169
Sadri-Vakili G., Kumaresan V., Schmidt H.D., Famous K.R., Chawla P., Vassoler F., Overland R., Xia E., Bass C.E., Terwilliger E., Pierce R.C., and Cha J-H. (2010).Cocaine-induced chromatin remodeling increases BDNF transcription in the medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. Journal of Neuroscience 30 (35): 11735-11744.
Kumaresan V., Menglu Y., Yee J., Schmidt H.D., Famous K.R. , and Pierce R.C. (2009) Role of nucleus accumbens metabotropic glutamate receptors (mGluR5) in the reinstatement of cocaine-seeking Behavioral Brain Research 202:238-244. PMCID: PMC2844436
Famous K.R., V. Kumaresan, G. Sadri-Vakili, H.D. Schmidt, D.F. Mierke, J.-H.J. Cha and R.C. Pierce. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens shell contributes to the reinstatement of cocaine seeking. Journal of Neuroscience 2008, 28 (43): 11061-1170. PMCID: PMC2601563.
Anderson S.M., *K.R. Famous, *G. Sadri-Vakili, *V. Kumaresan, H.D. Schmidt, C. Bass, E. Terwilliger, J.-H.J. Cha and R.C. Pierce (2008). Calcium/calmodulin-dependent protein kinase II(CaM-KII): the biochemical bridge linking nucleus accumbens dopamine and glutamate systems in the reinstatement of cocaine seeking. Nature Neuroscience 11(3):344-353
Pierce R.C., and Kumaresan V. (2006). The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neuroscience and Biobehavioral Reviews 30:216-238.
Schmidt H.D., S.M. Anderson, K.R. Famous, V. Kumaresan, and R.C. Pierce (2005) Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. European Journal of Pharmacology 526:65-76.
Kumaresan V., Kang C., and Simmons A.M. (1998) Development and Differentiation of Auditory Brainstem Nuclei of Rana catesbeiana Across metamorphosis : An Acetylcholinesterase Histochemical Study. Brain Behavior and Evolution. 52 (3): 111-125.
Selected Abstracts and Preprints
|Ratner MH, Downing S, Guo O, Odamah KA, Stewart TM, Kumaresan V, Xia W, Farb DH: Loss of tonic inhibitory control of sharp wave ripples in the TgF344-AD rat. Program/Poster No. P232.10. Presented at the Society for Neuroscience Annual Meeting, November 2021.
Ratner MH, Downing S, Guo O, Odamah KA, Stewart TM, Kumaresan V, Xia W, Farb DH: Does Modulation of Tonic Inhibition Control Sharp Wave Ripples and Hippocampal Place Cell Dynamics? Program/Poster No. P234.02. Presented at the Society for Neuroscience Annual Meeting, November 2021.
Ratner MH, Downing SS, Guo O, Odamah KE, Stewart TM, Kumaresan V, Robitsek RJ, Xia W, Farb DH. Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples in Alzheimer’s disease. bioRxiv; 2021.
Kumaresan V, Ratner MH, Sugunan K, Downing S, Casarella A, Li N, Joyal AA, Farb DH: Regulation of Activity Dependent Synaptic Plasticity and Synaptic Expression of Glutamate Receptors by the Neurosteroid Pregnenolone Sulfate: Implications for Learning and Memory. Program/Poster No. 576.25. Presented at Society for Neuroscience Annual Meeting, Washington, D.C.: Society for Neuroscience, 2017. Online.