Camron D. Bryant, Ph.D.
Ph.D., University of California, Los Angeles
Laboratory: To view Bryant Laboratory page click Laboratory of Addiction Genetics
Dr. Bryant is the Director of the Laboratory of Addiction Genetics. Dr. Bryant’s research program is focused on determining the genetic basis of behavioral and molecular traits relevant to substance dependence in mice. The ultimate goal is to improve our understanding of the neurobiological mechanisms of addiction and to translate these findings toward treatment and prevention strategies in humans. A current focus is to determine the genetic basis of the rewarding properties of opioids in mice by combining quantitative trait locus (QTL) analysis of behavior and gene expression in genetic reference populations that yield high resolution QTLs. This multi-pronged approach to gene mapping will accelerate the nomination of candidate genes for validation via direct gene targeting. A separate focus with regard to functional characterization of candidate genes is the dissection of the hypothesized opposing roles of casein kinase-1 (CK-1) isoforms in regulating dopaminergic signaling and the motivational properties of drugs of abuse. Last, Dr. Bryant has a longstanding interest in deciphering the neurobiological basis of the “placebo effect”, a phenomenon that has been hypothesized to be mediated by the reward expectation. He plans to develop and apply a forward genetic analysis toward Pavlovian conditioning mouse models across a variety of conditions that are notoriously sensitive to the placebo effect, including pain, anxiety, depression, and Parkinson’s Disease.
June 15, 2015: Joshua Wortzel started his summer position in the lab. Josh is a rising second-year medical student at Stanford University and is funded by the Stanford Medical Scholar Program to study the molecular mechanisms of the placebo effect. Josh also has an interest in hypnotism and other forms of alternative medicine. This summer he will study the correlation between placebo responsiveness and conditioned opioid reward behaviors in mice. His goal is to apply Pavlovian conditioning strategies that he learns this summer toward future studies involving the immune system.
June 1, 2015: Jenna Grant started her summer position in the lab working under the guidance of Neema Yazdani, Ph.D. candidate in the laboratory. Jenna is a summer intern who is funded by the National Institute on Drug Abuse (NIDA) and is currently investigating methamphetamine-induced signaling in casein kinase 1-epsilon knockout mice. Jenna is currently an undergraduate researcher at the University of New Orleans and is majoring in biology. Her future plan is to complete a Ph.D. in neurobiology/neuroscience.
May 15, 2015: Dr. Bryant (PI) was awarded 1R01DA039168-01A1, “Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice”. Dr. Karen Szumlinski is a Co-I on the grant and the two labs will use genome editing, RNA-seq, immunohistochemistry, and in vivo microdialysis to elucidate the role of Hnrnph1 in methamphetamine addiction-relevant behaviors.
May 15, 2015: Dr. Bryant’s abstract, “Food, Drugs, and QTLs: Mapping behavioral addiction traits in the Reduced Complexity Cross”, was accepted for an oral presentation for the 2015 Complex Trait Community Meeting in Portland, Oregon (http://www.complextrait.org/ctc2015/). Lisa will be presenting her work regarding behavioral and transcriptome analysis of casein kinase 1-epsilon knockout mice. In addition to presenting a poster, Lisa will also be participating in a Data Blitz where she will present new data where she has identified QTLs influencing behaviors associated with opioid reward and aversion.
May 8, 2015: Lisa Goldberg, senior Ph.D. candidate in the lab, won a travel award for the 2015 International Narcotics Research Conference to be held in Phoenix, AZ (http://www.inrcworld.org/2015/2015mtg.htm
April 23, 2015: Dr. Bryant was elected by the Society as Member at Large for the International Behavioural and Neural Genetics Society for 2015-2018. Members-at-large work with the President and Executive Committee on specific issues, including website management, updating the news section, and maintaining communication with other meetings and societies such as FENS
March 27, 2015: Kelsey Landaverde, undergraduate researcher in the Laboratory of Addiction Genetics, received a competitive UROP stipend award to study the mechanisms of placebo responding to anxiolytic treatment in mice. This project is part of a long-term goal to develop mouse models of placebo responding that can be subjected to forward genetic analysis. The “Placebo Effect” is a clinical phenomenon whereby patients, in particular those paitents experiencing pain, Parkinson’s disease, depression, or anxiety are particularly prone to exhibiting symptomatic relief in response to biologically inert substances that have no clinical utility. A long-standing hypothesis in the field is that the expectation of reward induces a neurobiolgical response that mediates symptomatic, though the neurobiological mechanisms by which these responses are induced remain largely unknown. Phenotypic variation in placebo responding suggests a genetic component; thus, the identification of novel genes mediating placebo-like responding in mice could have translational impact for understanding the genetic basis of placebo responding in humans.
March 11, 2015: Neema Yazdani, a third year PhD candidate and Biomolecular Pharmacology student in Dr. Bryant’s lab, is one of two graduate students selected for the 2015 “Outstanding Graduate Student Travel Award” for the 17th Annual International Behavioral and Neural Genetics Society (IBANGS) Meeting in Uppsala, Sweden. As a recipient of this award, Neema is invited to present his research as an oral presentation titled, “Hnrnph1 is a quantitative trait gene for methamphetamine sensitivity”. Neema’s efforts in generating and phenotyping TALENs-targeted Hnrnph1 knockout mice combined with striatal transcriptome analysis via RNA-seq led to the identification of Hnrnph1 as a novel quantitative trait gene involved in the stimulant response to methamphetamine. His transcriptome results suggest that Hnrnph1 could regulate the neural development of the mesocorticolimbic circuitry which would have widespread implications for understanding the etiology of a variety of neurobiological disorders involving a dysregulation of dopamine transmission.
January 6, 2015: Olga Lacki (Boston University Junior, Neuroscience Major) has once again received stipend support from BU’s UROP program for undergraduate research. Olga will continue to investigate the role of Csnk1e in signaling and addiction traits in response to drugs of abuse. Congratulations to Olga and a thank you to UROP for continuing to fund the research in our lab!
January 5, 2015: Dr. Bryant received the Jack Spivack Excellence in Neurosciences Research Award at Boston University which recognizes and supports the research of an outstanding faculty member at Boston University School of Medicine who is pursuing neurosciences research. Award recipients shall be conducting either clinical or basic neurosciences research in the areas of Parkinson’s, Alzheimer’s, Chronic Traumatic Encephalopathy and/or other neurological disorders.
December 16, 2014: Stacey Kirkpatrick’s manuscript, “Behavioral architecture of opioid reward and aversion in C57BL/6 substrains” was accepted for publication in Frontiers in Behavioral Neuroscience. Here, Stacey applied factor analysis toward multiple behaviors that were assessed in the conditioned place preference/aversion paradigm (CPP/CPA) and identified novel relationships that account for behavioral variation in oxycodone reward versus naloxone aversion. These results enhance our understanding of the behavioral structure of motivated behavior and provide a novel approach to assessing the genetic basis of substance abuse liability.
October 21, 2014: Dr. Bryant’s symposium proposal, “Genomic and neurobiological studies of RNA binding proteins in complex traits relevant to psychiatric disorders”, has been accepted for the 2015 Winter Conference on Brain Research in Big Sky, MA, to be held January 24-29.
July 25, 2014: Lisa Goldberg, Senior Graduate Student and Ph.D. Candidate in the Laboratory of Addiction Genetics, was accepted into the Short Course on the Genetics of Addiction at The Jackson Laboratory (http://courses.jax.org/2014/addiction.html) and was awarded a $1200 scholarship to attend the course by the National Institute on Drug Abuse.
June 20, 2014: Neema Yazdani, Graduate Student and Ph.D. Candidate in the Laboratory of Addiction Genetics, was accepted into the Short Course on the Genetics of Addiction at The Jackson Laboratory (http://courses.jax.org/2014/addiction.html). Neema is currently a trainee in the Transformative Training Program in Addiction Science (TTPAS; http://www.bumc.bu.edu/gms/ttpas/). TTPAS has generously agreed to provide funding for Neema to attend the course.
May 27, 2014: Dr. Bryant was awarded an R03 from NIDA, “Mapping G x E Interactions for Addiction Traits in a Reduced Complexity Cross”. The goal is to use closely related substrains of C57BL/6 mice to map gene by environment interactions in opioid reward, tolerance, and dependence caused by social drug cues of the cage mates. The findings gleaned from these studies will aid in understanding how the social context of the drug environment can potentially interact with one’s genome to influence behavioral traits that comprise addiction.
May 10-14, 2014: Members of the Laboratory of Addiction Genetics, including Dr. Bryant, Lisa Goldberg, Neema Yazdani, and Stacey Kirkpatrick attended the International Behavioural and Neural Genetics Society meeting in Chicago, IL. Members of the lab presented posters on their research and Dr. Bryant chaired a symposium, “Behavioral, neural, and genetic studies of compulsive eating in model organisms and humans” and presented the Young Scientist Lecture, “Genes, brain and addiction Traits: Moving from discovery toward validation and mechanism.”
April 28, 2014: Dr. Bryant gave a lecture at the Center for Studies of Addiction at University of Pennsylvania titled, “Mouse genomics and the neurobiology of substance abuse behavior: From drugs to food.
April 18, 2014: Dr. Bryant gave a lecture in the Department of Psychology Seminar at Middlebury College titled, “From drugs to food: Genetic approaches to the neurobiology of substance abuse in mice.”
March 31, 2014: Olga Lacki, undergraduate researcher (Neuroscience major, minor in Visual Arts), was awarded a competitive UROP summer scholarship for undergraduate research. Olga’s project is focused on identifying differences in psychostimulant and opioid-induced changes in cell signaling in the striatum as a consequence of inheriting a null mutation in casein kinase 1-epsilon (Csnk1e).
January 25-30: Dr. Bryant attended the 47th Annual Winter Conference on Brain Research at Steamboat Springs, CO. He gave a talk in the “CK1 and brain function” symposium titled, “A role for casein kinase 1-epsilon in the motivational properties of drugs of abuse.”
January 11, 2014: Dr. Bryant’s symposium proposal for the 2014 IBANGS Meeting in Chicago, IL has been accepted as one of six symposia scheduled for this year’s meeting. The title of the symposium that Dr. Bryant will chair is, “Behavioral, neural and genetic studies of compulsive eating in model organisms and humans.”
January 7, 2014: Alexis Washburn, a freshman undergraduate researcher in the Laboratory of Addiction Genetics, won a competitive Undegraduate Research Opportunity Program (UROP) Grant Award at Boston University for the Spring 2014 semester. This award includes both a stipend and money to help cover research costs. Alexis will have the opportunity to present her research at the Undergraduate Research Symposium in the fall. Alexis’s project involves using QTL mapping to identify novel genetic factors influencing compulsive eating in mice and has relevance toward understanding the genetic and biological mechanisms of eating disorders in humans. The long-term goal is to develop new avenues for prevention and treatment of these highly lethal, neuropsychiatric disorders.
December 17, 2013: Dr. Bryant has been selected as the recipient of the 2014 IBANGS Young Scientist Award. The Young Scientist Award honors a scientist who is 7 or fewer years post first faculty or faculty-equivalent appointment, and whose area of research is in behavioural and neural genetics. Key considerations are the scientific importance of research discoveries, record of achievement and future scientific plans and projected impact on the field.
November 16, 2013: A manuscript co-authored by Dr. Bryant has been accepted in the journal, Sleep, titled “The circadian clock gene Csnk1e regulates REM sleep and NREM sleep architecture in mice.”
October 18, 2013: Dr. Bryant’s presentation abstract was selected for a Travel Fellowship for the 2014 Winter Conference on Brain Research to be held in Steamboat Springs, Colorado.
October 16, 2013: Dr. Bryant has been invited to speak at the 47th Annual Winter Conference on Brain Research (WCBR) in Steamboat Springs, CO. He will be speaking in a symposium on CK1 and brain function. The title of his talk is, “A role for casein kinase 1-epsilon in the motivational properties of drugs of abuse.” He will be discussing Lisa Goldberg’s recent work regarding drug reward and dopaminergic signaling in CK1E knockout mice.
September 4, 2013. Dr. Bryant’s poster abstract, “A 0.23 Mb region regulates methamphetamine sensitivity in mice”, was selected among several hundred abstracts for a short oral presentation at the 2013 World Congress of Psychiatric Genetics (WCPG) held here in Boston. He will be speaking this Friday, October 18 during the afternoon poster talk workshop session (12:00-2:15 p.m.).
August 28, 2013: Neema Yazdani, M.S., second-year Ph.D. Student in Biomolecular Pharmacology in the Laboratory of Addiction Genetics, has been accepted into the Transformative Training Program in Addiction Science, supported by the Burroughs-Wellcome Fund and co-chaired by by Drs. Lindsay Farrer and Tim Heeren. For more information on this exciting multi-disciplinary training program in addiction see here (http://www.bumc.bu.edu/gms/ttpas/)
August 1, 2013: Neema Yazdani, M.S., second-year Ph.D. Student in Biomolecular Pharmacology, has joined the Laboratory of Addiction Genetics. Neema is using designer endonucleases to target novel candidate genes for methamphetamine-induced behavioral addiction traits and will be defining the cellular and molecular mechanisms of action that mediate genetic variation on behavior.
March 8, 2013: Dr. Bryant won the Outstanding Junior Faculty Travel Award for the 2013 International Behavioural and Neural Genetics Society (IBANGS) in Leuven, Belgium. Dr. Bryant’s abstract was selected for an invited talk that he will present during the Awardee session on May 21. In addition, Dr. Bryant will be provided with a stipend to cover his travel expenses.
December 3, 2012: Dr. Bryant presented his poster at the American College of Neuropsychopharmacology (ACNP) meeting, “A 0.23 Mb region on mouse chromosome 11 contains three possible genes influencing methamphetamine sensitivity” in Hollywood, FL. Please click here for a link to his poster.
November 30, 2012: Lisa Goldberg, a second year graduate student in Biomolecular Pharmacology and the Program in Biomedical Neuroscience has joined the Laboratory of Addiction Genetics. Welcome aboard, Lisa!
November 12, 2012: Dr. Bryant’s manuscript, “Bryant et al., in press” was accepted in Addiction Biology.
Goldberg LR, Yao EJ, Kelliher JC, Reed ER, Wu Cox J, Parks C, Kirkpatrick SL, Beierle JA, Chen MM, Johnson WE, Homanics GE, Williams RW, Bryant CD, Mulligan MK. A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity. Genes Brain Behav. 2021 Oct 22; e12774. PMID: 34677900.
Borrelli KN, Yao EJ, Yen WW, Phadke RA, Ruan QT, Chen MM, Kelliher JC, Langan CR, Scotellaro JL, Babbs RK, Beierle JC, Logan RW, Johnson WE, Wachman EM, Cruz-Martín A, Bryant CD. Sex Differences in Behavioral and Brainstem Transcriptomic Neuroadaptations following Neonatal Opioid Exposure in Outbred Mice. eNeuro. 2021 Sep-Oct; 8(5). PMID: 34479978.
Kantak KM, Stots C, Mathieson E, Bryant CD. Spontaneously Hypertensive Rat substrains show differences in model traits for addiction risk and cocaine self-administration: Implications for a novel rat reduced complexity cross. Behav Brain Res. 2021 08 06; 411:113406. PMID: 34097899.
Jimenez Chavez CL, Bryant CD, Munn-Chernoff MA, Szumlinski KK. Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains. Int J Mol Sci. 2021 May 21; 22(11). PMID: 34064099.
Yao EJ, Babbs RK, Kelliher JC, Luttik KP, Borrelli KN, Damaj MI, Mulligan MK, Bryant CD. Systems genetic analysis of binge-like eating in a C57BL/6J x DBA/2J-F2 cross. Genes Brain Behav. 2021 May 12; e12751. PMID: 33978997.
Borrelli KN, Langan CR, Dubinsky KR, Szumlinski KK, Carlezon WA, Chartoff EH, Bryant CD. Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice. Psychopharmacology (Berl). 2021 Jul; 238(7):2031-2041. PMID: 33758972.
Fultz EK, Coelho MA, Lieberman D, Jimenez-Chavez CL, Bryant CD, Szumlinski KK. Hnrnph1 is a novel regulator of alcohol reward. Drug Alcohol Depend. 2021 03 01; 220:108518. PMID: 33454624.
Bryant CD, Healy AF, Ruan QT, Coehlo MA, Lustig E, Yazdani N, Luttik KP, Tran T, Swancy I, Brewin LW, Chen MM, Szumlinski KK. Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice. Genes Brain Behav. 2021 03; 20(3):e12711. PMID: 33145940.
Shab G, Fultz EK, Page A, Coelho MA, Brewin LW, Stailey N, Brown CN, Bryant CD, Kippin TE, Szumlinski KK. The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice. Behav Brain Res. 2021 02 01; 398:112959. PMID: 33053382.
Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Al Abdullatif A, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020 Aug 26; 11(2):208. PMID: 32853540.
Wachman EM, Wang A, Isley BC, Boateng J, Beierle JA, Hansbury A, Shrestha H, Bryant C, Zhang H. Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study. Explor Med. 2020 Jun; 1(3):124-135.View Related Profiles. PMID: 33763662; DOI: 10.37349/emed.2020.00009;
Bryant CD, Smith DJ, Kantak KM, Nowak TS, Williams RW, Damaj MI, Redei EE, Chen H, Mulligan MK. Facilitating Complex Trait Analysis via Reduced Complexity Crosses. Trends Genet. 2020 08; 36(8):549-562.View Related Profiles. PMID: 32482413; DOI: 10.1016/j.tig.2020.05.003
Ulker E, Caillaud M, Patel T, White A, Rashid D, Alqasem M, Lichtman AH, Bryant CD, Damaj MI. C57BL/6 substrain differences in formalin-induced pain-like behavioral responses. Behav Brain Res. 2020 07 15; 390:112698. PMID: 32428630; DOI: 10.1016/j.bbr.2020.112698;
Ruan QT, Yazdani N, Reed ER, Beierle JA, Peterson LP, Luttik KP, Szumlinski KK, Johnson WE, Ash PEA, Wolozin B, Bryant CD. 5′ UTR variants in the quantitative trait gene Hnrnph1 support reduced 5′ UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. FASEB J. 2020 07; 34(7):9223-9244.View Related Profiles. PMID: 32401417; DOI: 10.1096/fj.202000092R;
Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020 04 22; 10(4):333-350.e14.View Related Profiles. PMID: 32325033; DOI: 10.1016/j.cels.2020.03.003
Babbs RK, Beierle JA, Yao EJ, Kelliher JC, Medeiros AR, Anandakumar J, Shah AA, Chen MM, Johnson WE, Bryant CD. The effect of the demyelinating agent cuprizone on binge-like eating of sweetened palatable food in female and male C57BL/6 substrains. Appetite. 2020 07 01; 150:104678.View Related Profiles. PMID: 32209386; DOI: 10.1016/j.appet.2020.104678
Brown CN, Fultz EK, Ferdousian S, Rogers S, Lustig E, Page A, Shahin JR, Flaherty DM, Von Jonquieres G, Bryant CD, Kippin TE, Szumlinski KK. Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice. Front Psychiatry. 2020; 11:11. PMID: 32116834; DOI: 10.3389/fpsyt.2020.00011
Sern KR, Fultz EK, Coelho MA, Bryant CD, Szumlinski KK. A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice. Subst Abuse. 2020; 14:1178221819897073. PMID: 32009790; DOI: 10.1177/1178221819897073
Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 01 02; 40(1):107-130.View Related Profiles. PMID: 31704785; DOI: 10.1523/JNEUROSCI.1808-19.2019
Babbs RK, Beierle JA, Ruan QT, Kelliher JC, Chen MM, Feng AX, Kirkpatrick SL, Benitez FA, Rodriguez FA, Pierre JJ, Anandakumar J, Kumar V, Mulligan MK, Bryant CD. Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex. G3 (Bethesda). 2019 09 04; 9(9):3009-3022.View Related Profiles. PMID: 31324746; DOI: 10.1534/g3.119.400470
Mulligan MK, Abreo T, Neuner SM, Parks C, Watkins CE, Houseal MT, Shapaker TM, Hook M, Tan H, Wang X, Ingels J, Peng J, Lu L, Kaczorowski CC, Bryant CD, Homanics GE, Williams RW. Identification of a Functional Non-coding Variant in the GABA A Receptor a2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research. Front Genet. 2019; 10:188. PMID: 30984232; DOI: 10.3389/fgene.2019.00188
Bryant CD, Bagdas D, Goldberg LR, Khalefa T, Reed ER, Kirkpatrick SL, Kelliher JC, Chen MM, Johnson WE, Mulligan MK, Imad Damaj M. C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception. Mol Pain. 2019 Jan-Dec; 15:1744806918825046.View Related Profiles. PMID: 30632432; DOI: 10.1177/1744806918825046
Babbs RK, Kelliher JC, Scotellaro JL, Luttik KP, Mulligan MK, Bryant CD. Genetic differences in the behavioral organization of binge eating, conditioned food reward, and compulsive-like eating in C57BL/6J and DBA/2J strains. Physiol Behav. 2018 12 01; 197:51-66. PMID: 30261172; DOI: 10.1016/j.physbeh.2018.09.013
Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neurosci Lett. 2018 09 25; 684:109-114.View Related Profiles. PMID: 30003938; DOI: 10.1016/j.neulet.2018.07.015
Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 01; 21(1):72-80.View Related Profiles.PMID:29273772; DOI:10.1038/s41593-017-0022-z
Goldberg LR, Kirkpatrick SL, Yazdani N, Luttik KP, Lacki OA, Keith Babbs R, Jenkins DF, Evan Johnson W, Bryant CD. Casein kinase 1-epsilon deletion increases mu opioid receptor-dependent behaviors and binge eating1. Genes Brain Behav. 2017 Sep; 16(7):725-738.View Related Profiles. PMID: 28594147; DOI: 10.1111/gbb.12397
Babbs RK*, Kelliher JC*, Scotellaro JL, Yazdani N, Ruan QT, Mulligan, MK, Bryant CD (2018). Genetic differences in the behavioral organization of binge eating, conditioned food reward, and compulsive-like eating C57BL/6J and DBA/2J strains. Accepted, Physiology and Behavior, https://doi.org/10.1101/190827
Bryant CD, Ferris MT, Manuel de Villena FPM, Damaj MI, Kumar V, Mulligan MK (2018). Ch. 14: Reduced complexity cross design for behavioral genetics. Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research. Publication date: June 2018. Edited by Wim E. Crusio and Robert T. Gerlai
Kirkpatrick SL, Goldberg LR, Yazdani N, Babbs RK, Wu J, Reed ER, Jenkins DF, Bolgioni AF, Landaverde KI, Luttik KP, Mitchell KS, Kumar V, Johnson WE, Mulligan MK, Cottone P, Bryant CD (2017). Cytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eating. Biological Psychiatry, 81(9): 757-769.
Young EE, Bryant CD, Lee SE, Peng X, Cook B, Nair HK, Dreher KJ, Zhang X, Palmer AA, Chung JM, Mogil JS, Chesler EJ, Lariviere WR (2016). Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the Von Frey test. In press, Genes, Brain and Behavior.
Yazdani N, Shen Y, Johnson WE, Bryant CD (2016). Striatal transcriptome analysis of a congenic mouse line (chromosome 11: 50-60 Mb) exhibiting a reduced locomotor stimulant response to methamphetamine. Genomics Data. June, 8: 77-80, doi: 10.1016/j.gdata.2016.03.009
Bryant CD, Yazdani N (2016). RNA binding proteins, neural development and the addictions. Genes, Brain and Behavior 15: 169-186.
Yazdani N, Parker CC, Shen Y, Reed ER, Guido MA, Kole LA, Kirkpatrick SL, Lim JE, Sokoloff G, Cheng R, Johnson WE, Palmer AA, Bryant CD (2015). Hnrnph1 is a quantitative trait gene for methamphetamine sensitivity. PLOS Genetics 11(12):e1005713.
Kirkpatrick, S. L., & Bryant, C. D. (2015). Behavioral architecture of opioid reward and aversion in C57BL/6 substrains. Frontiers in Behavioral Neuroscience, 8, 450. doi:10.3389/fnbeh.2014.00450
Zhou L, Bryant CD, Loudon AS, Palmer AA, Vitaterna MH, Turek FW (2014). The circadian clock gene Csnk1e regulates REM sleep and NREM sleep architecture in mice. Sleep, 37(4): 785-93.
Bryant CD, Guido MA, Kole LA, Cheng R. The heritability of oxycodone reward and concomitant phenotypes in a LG/J x SM/J F48 mouse advanced intercross line (2014). Addiction Biology, 19(4): 552-561
Kirkpatrick SL, Bryant CD(2015). Behavioral architecture of opioid reward and aversion in C57BL/6 substrains. Frontiers in Behavioral Neuroscience, 8:450.
Zhou L, Bryant CD, Loudon AS, Palmer AA, Vitaterna MH, Turek FW (2014). The circadian clock gene Csnk1e regulates REM sleep and NREM sleep architecture in mice. Sleep: 2014 Apr 1:37(4):785-93, 793A-793C. PMID 24744456. PMCID:PMC3972422
Bryant CD, Guido MA, Kole LA, Cheng R (2012). The heritability of oxycodone reward and concomitant phenotypes in a LG/J x SM/J mouse advanced intercross line. Addiction Biology, in press.
Bryant CD, Kole LA, Guido MA, Cheng R, Palmer AA (2012). Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line. Frontiers in Genetics 3:126
Bryant CD, Kole LA, Guido MA, Sokoloff G, Palmer AA (2012). Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis. Genes, Brain and Behavior 11(5):623-32
Bryant CD, Parker CC, Zhou L, Olker C, Chandrasekaran RY, Wager TT, Bolivar VJ, Loudon AS, Vitaterna MH, Turek FW, Palmer AA (2012). Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids. Neuropsychopharmacology 37(4):1026-35.
Bryant CD, Roberts KW, Culbertson CS, Le A, Evans CJ, Fanselow MS (2009). Pavlovian conditioning of multiple opioid-like responses in mice. Drug and Alcohol Dependence 103:74-83.
Bryant CD, Graham ME, Distler MG, Munoz MB, Li D, Vezina P, Sokoloff G, Palmer AA (2009). A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology 203(4):703-11.
Bryant CD, Zhang NN, Sokoloff G, Fanselow MS, Ennes HS, Palmer AA, McRoberts JA (2008). Behavioral differences among C57BL/6 substrains: Implications for transgenic and knockout studies. Journal of Neurogenetics 22(4):315-31.
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