Lulu Jiang, M.D., Ph.D.
Research Assistant Professor
Ph.D., National Institute of Environmental Health Sciences
M.D., Shandong University
- Dr. Jiang was a Postdoc Fellow in the Laboratory of Neurodegeneration mentored by Dr. Benjamin Wolozin. Her previous work demonstrated that propagated tau oligomers (but not tau fibrils) induce pathological changes in RNA metabolism and neurodegeneration. Upon that, Dr. Jiang developed an optogenetic system for controlling tau aggregation, which brought in a seminal discovery that tau oligomerization drives the accumulation of RNA binding protein HNRNPA2B1 and N6-methyladenosine modified transcripts in the aggregated tau complex. Dr. Jiang has also lead on the generation of human 3D iPSC M/AstAD based models of AD for the exploration of molecular mechanism and drug screening. Her research interests include: 1) Protein-Protein and Protein-RNA interactions in AD and related dementia; 2) Molecular mechanism of Tau prion-like propagation in Braak stages of AD; 3) Neuron-glia interactions in pathogenesis of AD and PD; 4) iPSC-induced 3D brain organoid models of neurodegenerative diseases and precision medicine; 5) Development of novel therapeutics for neurodegenerative diseases.
November 22, 2021
Dr. Jiang is invited as speaker on the Symposium of Single-cell genomics stem cells at AD/PD22: 16th International Conference on Alzheimer’s & Parkinson’s Diseases taking place Online and in Barcelona, Spain during March 15-20, 2022.
Sep 03, 2021
Dr. Jiang’s findings in Wolozin lab illustrated that oligomeric Tau binds indirectly to N6-methyladenosine (m6A)-modified RNA transcripts in the cytoplasm via the linker RNA-binding protein HNRNPA2B1. This discovery was published on Molecular Cell and marked as Research Highlight by Nature Reviews Molecular Cell Biology: Baumann, K. Tau oligomers are linked to m6A-RNA. Nat Rev Mol Cell Biol (2021). https://doi.org/10.1038/s41580-021-00419-w
Sep 14, 2021
Dr. Jiang’s publication “Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy” on Mol Cell was recommended and reported by Alzforum News with title: Methylated RNA: A New Player in Tau Toxicity?
Alzforum News: https://www.alzforum.org/news/research-news/methylated-rna-new-player-tau-toxicity.
Dr. Jiang’s research article published on Molecular Cell was reported by other News Media:
August 30, 2021
Genetic Engineering News by Jeffrey S. Buguliskis, Ph.D., title: Alzheimer’s Tau Protein Interacts with RNA to Induce Neurodegeneration, https://www.genengnews.com/news/alzheimers-tau-protein-interacts-with-rna-to-induce-neurodegeneration/
August 28, 2021
News-Medical.Net, title: Research analyzes the role of RNA tags in Alzheimer’s disease, https://www.news-medical.net/news/20210828/Research-analyzes-the-role-of-RNA-tags-in-Alzheimere28099s-disease.aspx
August 27, 2021
Medical Xpress, title: First study to investigate the role of RNA tags in Alzheimer’s disease, https://medicalxpress.com/news/2021-08-role-rna-tags-alzheimer-disease.html
1. Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, Abisambra JF, Kuo MH, Kanaan N, Murray ME, Crary JF, Zhao J, Cheng JX, Petrucelli L, Li H, Emili A, Wolozin B. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell. 2021 Aug 20:S1097-2765(21)00622-5. doi: 10.1016/j.molcel.2021.07.038. PMID: 34453888.
2. Hannah Rickner#, Lulu Jiang#, Rui Hong et al. Single cell transcriptomic profiling of neurodegeneration mediated by tau propagation in a novel 3D neuron-astrocyte coculture model, 01 March 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-263918/v1] (#Co- first authors, in press, Nov. 2021).
3. Jiang L, Wolozin B. Regulation of ribosomal function by oligomeric tau: Dysregulation of protein synthesis in neurodegeneration. Alzheimer’s & Dementia, 2020/12, 16, e039190
4. Jiang L, Zhao J, Cheng JX, Wolozin B. Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins. Front Neurol. 2020 Sep 30;11:579434. doi: 10.3389/fneur.2020.579434. PMID: 33101187; PMCID: PMC7554625.
5. Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathol. 2019 Feb;137(2):259-277. doi: 10.1007/s00401-018-1937-5. Epub 2018 Nov 21. PMID: 30465259; PMCID: PMC6377165.
6. Song S#, Jiang L#, Oyarzabal EA, Wilson B, Li Z, Shih YI, Wang Q, Hong JS. Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration. Mol Neurobiol. 2019 Apr;56(4):2653-2669. doi: 10.1007/s12035-018-1235-1. Epub 2018 Jul 27. PMID: 30051353; PMCID: PMC6348128. (# Co- first authors).
7. Jiang L, Wu X, Wang S, Chen SH, Zhou H, Wilson B, Jin CY, Lu RB, Xie K, Wang Q, Hong JS. Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2016 May 16; 13(1):110. doi: 10.1186/s12974-016-0573-z.
8. Jiang L, Chen SH, Chu CH, Wang SJ, Oyarzabal E, Wilson B, Sanders V, Xie K, Wang Q, Hong JS. A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis. Glia. 2015 Jun; 63(6):1057-72. doi: 10.1002/glia.22801.
9. Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, Kanaan NM, Wolozin B. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci USA. 2021 Mar 2;118(9):e2014188118. doi: 10.1073/pnas.2014188118. PMID: 33619090; PMCID: PMC7936275.
10. Wang Q, Song S, Jiang L, Hong JS. Interplay among norepinephrine, NOX2, and neuroinflammation: key players in Parkinson’s disease and prime targets for therapies. Ageing Neur Dis 2021;1:6. http://dx.doi.org/10.20517/and.2021.06.
11. Apicco DJ, Zhang C, Maziuk B, Jiang L, Ballance HI, Boudeau S, Ung C, Li H, Wolozin B. Dysregulation of RNA Splicing in Tauopathies. Cell Rep. 2019 Dec 24;29(13):4377-4388.e4. doi: 10.1016/j.celrep.2019.11.093.
12. Song S, Wang Q, Jiang L, Oyarzabal E, Riddick NV, Wilson B, Moy SS, Shih YI, Ho
ng JS. Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions. Brain Behav Immun. 2019 Oct;81:374-387. doi: 10.1016/j.bbi.2019.06.034. Epub 2019 Jun 24.
13. Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH, Leszyk J, Abisambra JF, Li H, Wolozin B. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun. 2018 Aug 1;6(1):71. doi: 10.1186/s40478-018-0574-5.
14. Wang Q, Chu CH, Oyarzabal E, Jiang L, Chen SH, Wilson B, Qian L, Hong JS. 2014. Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases. Glia. 2014 Dec; 62(12):2034-43. doi: 10.1002/glia.22724.
15. Wang Q, Chu CH, Qian L, Chen SH, Wilson B, Oyarzabal E, Jiang L, Ali S, Robinson B, Kim HC, Hong JS. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J Neurosci. 2014 Sep 10; 34(37):12490-503. doi: 10.1523/JNEUROSCI.2238-14.2014.
Complete List of Published Work in MyBibliography:
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